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Using a zebrafish explant model of anteroposterior axis extension, we show that C&amp;E of the neuroectoderm and mesoderm can be uncoupled ex vivo, and that morphogenesis of individual tissues results from distinct morphogen signaling dynamics. Using precise temporal manipulation of BMP and Nodal signaling, we identify a critical developmental window during which high or low BMP\/Nodal ratios induce neuroectoderm- or mesoderm-driven C&amp;E, respectively. Increased BMP activity similarly enhances C&amp;E specifically in the ectoderm of intact zebrafish gastrulae, highlighting the in vivo relevance of our findings. Together, these results demonstrate that temporal dynamics of BMP and Nodal morphogen signaling activate distinct morphogenetic programs governing C&amp;E gastrulation movements within individual tissues.<\/jats:p>","DOI":"10.1242\/dev.202931","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:08:51Z","timestamp":1733728131000},"source":"Crossref","is-referenced-by-count":9,"title":["Temporal dynamics of BMP\/Nodal ratio drive tissue-specific gastrulation morphogenesis"],"prefix":"10.1242","volume":"152","author":[{"given":"Alyssa A.","family":"Emig","sequence":"first","affiliation":[{"name":"Center for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine 1 , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Hansen","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine 1 , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Grimm","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine 1 , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Coarfa","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine 1 , Houston, TX 77030 ,","place":["USA"]},{"name":"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine 2 , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan D.","family":"Lord","sequence":"additional","affiliation":[{"name":"University of Pittsburgh 3 Department of Computational and Systems Biology , , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-6301","authenticated-orcid":false,"given":"Margot Kossmann","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Precision Environmental Health and Department of Molecular and Cellular Biology, Baylor College of Medicine 1 , Houston, TX 77030 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"2025050105265823900_DEV202931C1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1242\/dev.00905","article-title":"Xenopus Meis3 protein forms a hindbrain-inducing center by activating FGF\/MAP kinase and PCP pathways","volume":"131","author":"Aamar","year":"2004","journal-title":"Development"},{"key":"2025050105265823900_DEV202931C2","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature01822","article-title":"The molecular nature of the zebrafish tail organizer","volume":"424","author":"Agathon","year":"2003","journal-title":"Nature"},{"key":"2025050105265823900_DEV202931C3","doi-asserted-by":"publisher","first-page":"62797","DOI":"10.3791\/62797","article-title":"Generation of na\u00efve blastoderm explants from zebrafish embryos","volume":"173","author":"Alaniz Emig","year":"2021","journal-title":"J. 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