{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:28:03Z","timestamp":1768638483409,"version":"3.49.0"},"reference-count":65,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006196","name":"Oulun Yliopisto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Research Council of Finland","award":["AF 336449"],"award-info":[{"award-number":["AF 336449"]}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","award":["NGP10125"],"award-info":[{"award-number":["NGP10125"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD032067"],"award-info":[{"award-number":["HD032067"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD105800"],"award-info":[{"award-number":["HD105800"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD096057"],"award-info":[{"award-number":["HD096057"]}]},{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD110038"],"award-info":[{"award-number":["HD110038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Effective interplay between the uterus and the embryo is essential for pregnancy establishment; however, convenient methods to screen embryo implantation success and maternal uterine response in experimental mouse models are currently lacking. Here, we report 3DMOUSEneST, a groundbreaking method for analyzing mouse implantation sites based on label-free higher harmonic generation microscopy, providing unprecedented insights into the embryo\u2013uterine dynamics during early pregnancy. The 3DMOUSEneST method incorporates second-harmonic generation microscopy to image the three-dimensional structure formed by decidual fibrillar collagen, named \u2018decidual nest\u2019, and third-harmonic generation microscopy to evaluate early conceptus (defined as the embryo and extra-embryonic tissues) growth. We demonstrate that decidual nest volume is a measurable indicator of decidualization efficacy and correlates with the probability of early pregnancy progression based on a logistic regression analysis using Smad1\/5 and Smad2\/3 conditional knockout mice with known implantation defects. 3DMOUSEneST has great potential to become a principal method for studying decidual fibrillar collagen and characterizing mouse models associated with early embryonic lethality and fertility issues.<\/jats:p>","DOI":"10.1242\/dev.202938","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T11:49:04Z","timestamp":1721303344000},"source":"Crossref","is-referenced-by-count":6,"title":["3DMOUSEneST: a volumetric label-free imaging method evaluating embryo\u2013uterine interaction and decidualization efficacy"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-8886","authenticated-orcid":false,"given":"Audrey","family":"Savolainen","sequence":"first","affiliation":[{"name":"University of Oulu 1 Faculty of Biochemistry and Molecular Medicine , , 90220 Oulu , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-3544","authenticated-orcid":false,"given":"Emmi","family":"Kapiainen","sequence":"additional","affiliation":[{"name":"University of Oulu 1 Faculty of Biochemistry and Molecular Medicine , , 90220 Oulu , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3050-4579","authenticated-orcid":false,"given":"Veli-Pekka","family":"Ronkainen","sequence":"additional","affiliation":[{"name":"Biocenter Oulu, University of Oulu 2 , 90220 Oulu , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9960-4917","authenticated-orcid":false,"given":"Valerio","family":"Izzi","sequence":"additional","affiliation":[{"name":"University of Oulu 1 Faculty of Biochemistry and Molecular Medicine , , 90220 Oulu , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1445-8632","authenticated-orcid":false,"given":"Martin M.","family":"Matzuk","sequence":"additional","affiliation":[{"name":"Center for Drug Discovery, Baylor College of Medicine 3 , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 4 Department of Pathology & Immunology , , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-6392","authenticated-orcid":false,"given":"Diana","family":"Monsivais","sequence":"additional","affiliation":[{"name":"Center for Drug Discovery, Baylor College of Medicine 3 , Houston, TX 77030 , USA"},{"name":"Baylor College of Medicine 4 Department of Pathology & Immunology , , Houston, TX 77030 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5453-2983","authenticated-orcid":false,"given":"Renata","family":"Prunskaite-Hyyryl\u00e4inen","sequence":"additional","affiliation":[{"name":"University of Oulu 1 Faculty of Biochemistry and Molecular Medicine , , 90220 Oulu , Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2024082911045326300_DEV202938C1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1242\/dmm.012898","article-title":"Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening","volume":"6","author":"Adams","year":"2013","journal-title":"Dis. 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