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Here, we used quantitative live imaging of endogenous Scute (Sc), a proneural factor, and of a Notch activity reporter to study the emergence of sensory organ precursor cells in the pupal abdomen of Drosophila. SB was observed at low Sc levels and was not preceded by a phase of intermediate Sc expression and Notch activity. Thus, mutual inhibition may only be transient in this context. In support of the intercellular feedback loop model, cell-to-cell variations in Sc levels promoted fate divergence. The size of the apical area of competing cells did not detectably bias this fate choice. Surprisingly, cells that were in direct contact at the time of SB could adopt the sensory organ precursor cell fate, albeit at low frequency (10%). These lateral inhibition defects were corrected by cellular rearrangements, not cell fate change, highlighting the role of cell-cell intercalation in pattern refinement.<\/jats:p>","DOI":"10.1242\/dev.203165","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:33:53Z","timestamp":1728290033000},"source":"Crossref","is-referenced-by-count":8,"title":["Symmetry breaking and fate divergence during lateral inhibition in\n                    <i>Drosophila<\/i>"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-1351","authenticated-orcid":false,"given":"Minh-Son","family":"Phan","sequence":"first","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang-mi","family":"Kim","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]},{"name":"Cellule Pasteur, Sorbonne Universit\u00e9 2 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Picciotto","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7843-6814","authenticated-orcid":false,"given":"Lydie","family":"Couturier","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisha","family":"Veits","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khallil","family":"Mazouni","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8888-9390","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Schweisguth","sequence":"additional","affiliation":[{"name":"Institut Pasteur, CNRS UMR3738, Universit\u00e9 Paris Cit\u00e9, 4D Unit 1 , F-75015 Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"2024110819053005700_DEV203165C1","doi-asserted-by":"publisher","first-page":"e1000435","DOI":"10.1371\/journal.pbio.1000435","article-title":"Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification","volume":"8","author":"Aerts","year":"2010","journal-title":"PLoS Biol."},{"key":"2024110819053005700_DEV203165C2","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/978-1-0716-2541-5_20","article-title":"Segmentation and quantitative analysis of epithelial tissues","volume":"2540","author":"Aigouy","year":"2022","journal-title":"Methods Mol. 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