{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:10:53Z","timestamp":1785222653045,"version":"3.55.0"},"reference-count":45,"publisher":"The Company of Biologists","issue":"3","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG KI728\/8-2"],"award-info":[{"award-number":["DFG KI728\/8-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["DFG KI728\/9-2"],"award-info":[{"award-number":["DFG KI728\/9-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005624","name":"Hannover Medical School","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005624","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>In mammalian ureters, the lamina propria presents as a prominent layer of connective tissue underneath the urothelium. Despite its important structural and signaling functions, little is known how the lamina propria develops. Here, we show that in the murine ureter the lamina propria arises at late fetal stages and massively increases by fibrocyte proliferation and collagen deposition after birth. WNT, SHH, BMP4 and retinoic acid signaling are all active in the common mesenchymal progenitor of smooth muscle cells and lamina propria fibrocytes. However, around birth, the lamina propria becomes a target for epithelial WNT and SHH signals and a source of BMP4 and retinoic acid. SHH and WNT signaling promote lamina propria and smooth muscle cell differentiation and proliferation at fetal and early postnatal stages, whereas BMP4 signaling is required for early smooth muscle cell differentiation but not for its later maintenance. Our findings suggest that, in the presence of SHH and WNT signaling, it is the modulation of BMP4 signaling which is the major determinant for the segregation of lamina propria and smooth muscle cells.<\/jats:p>","DOI":"10.1242\/dev.204214","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T13:13:49Z","timestamp":1737033229000},"source":"Crossref","is-referenced-by-count":8,"title":["Interplay of SHH, WNT and BMP4 signaling regulates the development of the lamina propria in the murine ureter"],"prefix":"10.1242","volume":"152","author":[{"given":"Philipp","family":"Straube","sequence":"first","affiliation":[{"name":"Hannover Medical School Institute of Molecular Biology , , 30625 Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Beckers","sequence":"additional","affiliation":[{"name":"Hannover Medical School Institute of Molecular Biology , , 30625 Hannover ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4506-3817","authenticated-orcid":false,"given":"Ulrich W. 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