{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:26:05Z","timestamp":1791091565034,"version":"4.1.0"},"reference-count":102,"publisher":"The Company of Biologists","issue":"24","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R37MH085726"],"award-info":[{"award-number":["R37MH085726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R35GM112548"],"award-info":[{"award-number":["R35GM112548"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01NS092096"],"award-info":[{"award-number":["R01NS092096"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017050","name":"Cycle for Survival","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Cancer Institute","award":["P30 CA008748-48"],"award-info":[{"award-number":["P30 CA008748-48"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>More than 40 years ago, studies of the Drosophila engrailed and Hox genes led to major discoveries that shaped the history of developmental biology. We learned that these genes define the state of determination of cells that populate particular spatially defined regions: the identity of segmental domains by Hox genes, and the identity of posterior developmental compartments by engrailed. Hence, the boundaries that delimit spatial domains depend on engrailed. Here, we review the engrailed field, which now includes orthologs in Drosophila and mouse, as well as many other animals. We focus on fly and mouse and highlight additional functions that span early stages of embryogenesis and neural development.<\/jats:p>","DOI":"10.1242\/dev.204250","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T15:12:03Z","timestamp":1734102723000},"source":"Crossref","is-referenced-by-count":3,"title":["Conserved roles of engrailed: patterning tissues and specifying cell types"],"prefix":"10.1242","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-9605","authenticated-orcid":false,"given":"Alexandra L.","family":"Joyner","sequence":"first","affiliation":[{"name":"Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center 1 Developmental Biology Program , , New York, NY 10021 ,","place":["USA"]},{"name":"Weill Cornell Graduate School of Medical Sciences 2 Biochemistry, Cell & Molecular Biology Program and Neuroscience Program , , New York, NY 10021 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Ramalho","family":"Ortig\u00e3o-Farias","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco 3 , San Francisco, CA 94158 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kornberg","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, University of California, San Francisco 3 , San Francisco, CA 94158 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"2025050204460817400_DEV204250C1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ydbio.2017.08.011","article-title":"Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility","volume":"430","author":"Ahmed","year":"2017","journal-title":"Dev. 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