{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:58:19Z","timestamp":1780055899573,"version":"3.54.0"},"reference-count":60,"publisher":"The Company of Biologists","issue":"22","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2019YFA0801601"],"award-info":[{"award-number":["2019YFA0801601"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31930029"],"award-info":[{"award-number":["31930029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91854111"],"award-info":[{"award-number":["91854111"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Center for International Research of Genomics","award":["2017B01012"],"award-info":[{"award-number":["2017B01012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion syndrome. Congenital heart defects are prevalent in 22q11.2DS but the etiology is still poorly understood. In this study, we aimed to gain mechanistic insights into the heart defects that result from 22q11.2 deletion, with a focus on Slc25a1, which is located in the deletion segment. Whereas global knockout of Slc25a1 in mice produced a variety of heart malformations, cardiac deletion of Slc25a1 had little effect on heart development. We then found that trophoblast-specific Slc25a1 deletion recapitulated heart anomalies in the global knockout mice. Further study identified SLC25A1 as a regulator of trophoblast and placental development through modulation of histone H3K27 acetylation at the promoters and enhancers of key genes involved in trophoblast differentiation. Finally, administration of recombinant human pregnancy-specific glycoprotein 1 (PSG1), a trophoblast-derived secretory glycoprotein, partially corrected placental and embryonic heart defects. This study defines the role of SLC25A1 in heart development by regulating placental development, and provides new insights to understand the etiology of 22q11.2DS.<\/jats:p>","DOI":"10.1242\/dev.204290","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T22:01:33Z","timestamp":1732658493000},"source":"Crossref","is-referenced-by-count":10,"title":["SLC25A1 regulates placental development to ensure embryonic heart morphogenesis"],"prefix":"10.1242","volume":"151","author":[{"given":"Wenli","family":"Fan","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School 1 , Nanjing 210093 ,","place":["China"]},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School 2 , Nanjing 210093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Li","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School 1 , Nanjing 210093 ,","place":["China"]},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School 2 , Nanjing 210093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"He","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School 1 , Nanjing 210093 ,","place":["China"]},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School 2 , Nanjing 210093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School 1 , Nanjing 210093 ,","place":["China"]},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School 2 , Nanjing 210093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1424-3344","authenticated-orcid":false,"given":"Ming","family":"Sun","sequence":"additional","affiliation":[{"name":"Suqian Scientific Research Institute of Nanjing University Medical School, Nanjing University 3 , Suqian, Jiangsu 223800 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3272-5255","authenticated-orcid":false,"given":"Zhongzhou","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School 1 , Nanjing 210093 ,","place":["China"]},{"name":"Jiangsu Key Laboratory of Molecular Medicine, Nanjing University Medical School 2 , Nanjing 210093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"2024112622003269600_DEV204290C1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S1097-2765(05)00014-6","article-title":"Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development","volume":"6","author":"Adams","year":"2000","journal-title":"Mol. Cell"},{"key":"2024112622003269600_DEV204290C2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cphy.c170012","article-title":"Triglyceride metabolism in the liver","volume":"8","author":"Alves-Bezerra","year":"2017","journal-title":"Compr. Physiol."},{"key":"2024112622003269600_DEV204290C3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S1097-2765(00)80209-9","article-title":"PPAR gamma is required for placental, cardiac, and adipose tissue development","volume":"4","author":"Barak","year":"1999","journal-title":"Mol. Cell"},{"key":"2024112622003269600_DEV204290C4","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1093\/eurheartj\/ehaa554","article-title":"2020 ESC Guidelines for the management of adult congenital heart disease","volume":"42","author":"Baumgartner","year":"2021","journal-title":"Eur. Heart J."},{"key":"2024112622003269600_DEV204290C5","doi-asserted-by":"publisher","first-page":"e1007587","DOI":"10.1371\/journal.pgen.1007587","article-title":"Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage","volume":"14","author":"Bogutz","year":"2018","journal-title":"PLoS Genet."},{"key":"2024112622003269600_DEV204290C6","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.placenta.2005.09.009","article-title":"Tracing the glycogen cells with protocadherin 12 during mouse placenta development","volume":"27","author":"Bouillot","year":"2006","journal-title":"Placenta"},{"key":"2024112622003269600_DEV204290C56","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ydbio.2003.10.039","article-title":"Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects","volume":"267","author":"Brewer","year":"2004","journal-title":"Dev. Biol"},{"key":"2024112622003269600_DEV204290C7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.repbio.2016.07.001","article-title":"PLAC1 is involved in human trophoblast syncytialization","volume":"16","author":"Chang","year":"2016","journal-title":"Reprod. Biol."},{"key":"2024112622003269600_DEV204290C8","doi-asserted-by":"publisher","first-page":"3280","DOI":"10.1002\/dvdy.20981","article-title":"Origin and characteristics of glycogen cells in the developing murine placenta","volume":"235","author":"Coan","year":"2006","journal-title":"Dev. Dyn."},{"key":"2024112622003269600_DEV204290C9","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.123.063657","article-title":"Don't break the axis: placental inflammation leads to congenital heart disease","volume":"147","author":"De La Pompa","year":"2023","journal-title":"Circulation"},{"key":"2024112622003269600_DEV204290C10","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1242\/dev.01819","article-title":"Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning","volume":"132","author":"Donnison","year":"2005","journal-title":"Development"},{"key":"2024112622003269600_DEV204290C11","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ydbio.2009.10.009","article-title":"The role of secondary heart field in cardiac development","volume":"336","author":"Dyer","year":"2009","journal-title":"Dev. Biol."},{"key":"2024112622003269600_DEV204290C12","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/01.RES.84.2.127","article-title":"HIRA, a DiGeorge syndrome candidate gene, is required for cardiac outflow tract septation","volume":"84","author":"Farrell","year":"1999","journal-title":"Circ. Res."},{"key":"2024112622003269600_DEV204290C57","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.1128\/mcb.00420-10","article-title":"PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development","volume":"30","author":"Feng","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"2024112622003269600_DEV204290C13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000089039","article-title":"Placental lesions in a case of DiGeorge sequence","volume":"21","author":"Fulcheri","year":"2006","journal-title":"Fetal Diagn. Ther."},{"key":"2024112622003269600_DEV204290C14","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1159\/000484154","article-title":"Plac1 expression pattern at the mouse fetomaternal interface and involvement in trophoblast differentiation","volume":"43","author":"Gu","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"2024112622003269600_DEV204290C15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/371333a0","article-title":"Essential role of Mash-2 in extraembryonic development","volume":"371","author":"Guillemot","year":"1994","journal-title":"Nature"},{"key":"2024112622003269600_DEV204290C16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1042\/BJ20121753","article-title":"Physiological and pathological roles of mitochondrial SLC25 carriers","volume":"454","author":"Gutierrez-Aguilar","year":"2013","journal-title":"Biochem. J."},{"key":"2024112622003269600_DEV204290C17","first-page":"1255","article-title":"The effect on pregnancy of intrauterine administration of antibodies against two pregnancy-associated murine proteins: murine pregnancy-specific beta 1-glycoprotein and murine pregnancy-associated alpha 2-glycoprotein","volume":"44","author":"Hau","year":"1985","journal-title":"Biomed. Biochim. Acta"},{"key":"2024112622003269600_DEV204290C18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0925-4773(02)00292-7","article-title":"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain","volume":"2","author":"Hayashi","year":"2002","journal-title":"Gene Expr. Patterns"},{"key":"2024112622003269600_DEV204290C19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"2024112622003269600_DEV204290C20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0020-7292(83)90047-4","article-title":"Human placental lactogen, pregnancy\u2013specific beta\u20131\u2013glycoprotein and alpha\u2013fetoprotein in serum in threatened abortion","volume":"21","author":"Hertz","year":"2004","journal-title":"Int. J. Gynecol. Obstetrics"},{"key":"2024112622003269600_DEV204290C21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1126\/science.aam6607","article-title":"ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice","volume":"357","author":"Ho","year":"2017","journal-title":"Science"},{"key":"2024112622003269600_DEV204290C22","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1387\/ijdb.082768dh","article-title":"Development and function of trophoblast giant cells in the rodent placenta","volume":"54","author":"Hu","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"2024112622003269600_DEV204290C23","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1262\/jrd.50.515","article-title":"Cathepsin gene expression in mouse placenta during the latter half of pregnancy","volume":"50","author":"Ishida","year":"2004","journal-title":"J. Reprod. Dev."},{"key":"2024112622003269600_DEV204290C24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41421-022-00513-z","article-title":"A differentiation roadmap of murine placentation at single-cell resolution","volume":"9","author":"Jiang","year":"2023","journal-title":"Cell Discov."},{"key":"2024112622003269600_DEV204290C25","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.18.549409","article-title":"Loss of the mitochondrial carrier, SLC25A1, during embryogenesis induces a unique senescence program controlled by p53","author":"Kasprzyk-Pawelec","year":"2024","journal-title":"bioRxiv"},{"key":"2024112622003269600_DEV204290C26","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nat. Commun."},{"key":"2024112622003269600_DEV204290C27","doi-asserted-by":"publisher","first-page":"e23101","DOI":"10.1002\/dvg.23101","article-title":"Generation of Elf5-Cre knockin mouse strain for trophoblast-specific gene manipulation","volume":"56","author":"Kong","year":"2018","journal-title":"Genesis"},{"key":"2024112622003269600_DEV204290C28","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1432-1033.1996.0280r.x","article-title":"Coordinate expression of splice variants of the murine Pregnancy\u2013Specific Glycoprotein (PSG) gene family during placental development","volume":"242","author":"Kromer","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"2024112622003269600_DEV204290C29","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/s41467-024-45647-8","article-title":"PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development","volume":"15","author":"Lee","year":"2024","journal-title":"Nat. Commun."},{"key":"2024112622003269600_DEV204290C30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2024112622003269600_DEV204290C31","doi-asserted-by":"publisher","first-page":"e60266","DOI":"10.7554\/eLife.60266","article-title":"Single nuclei RNA-seq of mouse placental labyrinth development","volume":"9","author":"Marsh","year":"2020","journal-title":"eLife"},{"key":"2024112622003269600_DEV204290C32","doi-asserted-by":"publisher","first-page":"735","DOI":"10.3389\/fphys.2018.00735","article-title":"Recent advances in placenta-heart interactions","volume":"9","author":"Maslen","year":"2018","journal-title":"Front. Physiol."},{"key":"2024112622003269600_DEV204290C33","doi-asserted-by":"publisher","first-page":"15071","DOI":"10.1038\/nrdp.2015.71","article-title":"22q11.2 deletion syndrome","volume":"1","author":"McDonald-McGinn","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2024112622003269600_DEV204290C34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1471-2164-6-4","article-title":"Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus","volume":"6","author":"McLellan","year":"2005","journal-title":"BMC Genomics"},{"key":"2024112622003269600_DEV204290C35","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1471-2148-5-39","article-title":"Conservation of pregnancy-specific glycoprotein (PSG) N domains following independent expansions of the gene families in rodents and primates","volume":"5","author":"McLellan","year":"2005","journal-title":"BMC Evol. Biol."},{"key":"2024112622003269600_DEV204290C36","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1002\/ajmg.a.40504","article-title":"Molecular genetics of 22q11.2 deletion syndrome","volume":"176","author":"Morrow","year":"2018","journal-title":"Am. J. Med. Genet. A"},{"key":"2024112622003269600_DEV204290C37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41569-021-00587-4","article-title":"Genomic frontiers in congenital heart disease","volume":"19","author":"Morton","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"2024112622003269600_DEV204290C38","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front. Physiol."},{"key":"2024112622003269600_DEV204290C58","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.celrep.2015.09.043","article-title":"Post-transcriptional regulation of Nkx2-5 by RHAU in heart development","volume":"13","author":"Nie","year":"2015","journal-title":"Cell Rep."},{"key":"2024112622003269600_DEV204290C39","doi-asserted-by":"publisher","DOI":"10.1101\/2023.05.22.541833","article-title":"Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart","author":"Ohanele","year":"2023","journal-title":"bioRxiv"},{"key":"2024112622003269600_DEV204290C40","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13148-018-0508-x","article-title":"H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction","volume":"10","author":"Paauw","year":"2018","journal-title":"Clin. Epigenet."},{"key":"2024112622003269600_DEV204290C41","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature26002","article-title":"Placentation defects are highly prevalent in embryonic lethal mouse mutants","volume":"555","author":"Perez-Garcia","year":"2018","journal-title":"Nature"},{"key":"2024112622003269600_DEV204290C42","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/s41467-023-36740-5","article-title":"Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease","volume":"14","author":"Radford","year":"2023","journal-title":"Nat. Commun."},{"key":"2024112622003269600_DEV204290C43","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.yexcr.2004.08.024","article-title":"Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells","volume":"302","author":"Rampon","year":"2005","journal-title":"Exp. Cell Res."},{"key":"2024112622003269600_DEV204290C44","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1093\/biolre\/ioy033","article-title":"SATB1 downregulation induced by oxidative stress participates in trophoblast invasion by regulating \u03b2-catenin","volume":"98","author":"Rao","year":"2018","journal-title":"Biol. Reprod."},{"key":"2024112622003269600_DEV204290C45","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"2024112622003269600_DEV204290C46","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"Shi","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"2024112622003269600_DEV204290C47","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41580-021-00441-y","article-title":"Modulation of cellular processes by histone and non-histone protein acetylation","volume":"23","author":"Shvedunova","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024112622003269600_DEV204290C48","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.ydbio.2007.01.009","article-title":"Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta","volume":"304","author":"Simmons","year":"2007","journal-title":"Dev. Biol."},{"key":"2024112622003269600_DEV204290C49","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1242\/dev.01801","article-title":"Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst","volume":"132","author":"Strumpf","year":"2005","journal-title":"Development"},{"key":"2024112622003269600_DEV204290C50","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/(SICI)1526-968X(200002)26:2&lt;113::AID-GENE3&gt;3.0.CO;2-2","article-title":"Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function","volume":"26","author":"Tallquist","year":"2000","journal-title":"Genesis"},{"key":"2024112622003269600_DEV204290C51","doi-asserted-by":"publisher","first-page":"eabj5445","DOI":"10.1126\/sciadv.abj5445","article-title":"Adhesion G protein-coupled receptor Gpr126\/Adgrg6 is essential for placental development","volume":"7","author":"Torregrosa-Carri\u00f3n","year":"2021","journal-title":"Sci. Adv."},{"key":"2024112622003269600_DEV204290C52","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.devcel.2013.10.019","article-title":"c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface","volume":"27","author":"Ueno","year":"2013","journal-title":"Dev. Cell"},{"key":"2024112622003269600_DEV204290C53","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/bies.201500087","article-title":"The basal chorionic trophoblast cell layer: an emerging coordinator of placenta development","volume":"38","author":"Walentin","year":"2016","journal-title":"BioEssays"},{"key":"2024112622003269600_DEV204290C54","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1161\/CIRCULATIONAHA.122.061934","article-title":"Placental inflammation leads to abnormal embryonic heart development","volume":"147","author":"Ward","year":"2023","journal-title":"Circulation"},{"key":"2024112622003269600_DEV204290C59","doi-asserted-by":"publisher","first-page":"dev177477","DOI":"10.1242\/dev.177477","article-title":"HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis","volume":"146","author":"Xia","year":"2019","journal-title":"Development"},{"key":"2024112622003269600_DEV204290C60","doi-asserted-by":"publisher","first-page":"dev199026","DOI":"10.1242\/dev.199026","article-title":"The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development","volume":"148","author":"Xu","year":"2021","journal-title":"Development"},{"key":"2024112622003269600_DEV204290C55","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/S0140-6736(03)14632-6","article-title":"Role of TBX1 in human del22q11.2 syndrome","volume":"362","author":"Yagi","year":"2003","journal-title":"Lancet"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204290\/3583661\/dev204290.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204290\/3583661\/dev204290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T22:01:38Z","timestamp":1732658498000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/151\/22\/dev204290\/363170\/SLC25A1-regulates-placental-development-to-ensure"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":60,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.204290","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,15]]},"article-number":"dev204290"}}