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While its dual cellular origin is well understood, the molecules underlying its formation remain relatively obscure. Trigeminal ganglion assembly is mediated, in part, by neural cadherin (N-cadherin), which is initially expressed by placodal neurons and is required for their proper coalescence with neural crest cells. Axon outgrowth first occurs from placodal neurons, but as gangliogenesis proceeds, neural crest cells also differentiate into N-cadherin-expressing neurons, and both extend axons toward targets. However, the role of N-cadherin in axon outgrowth and target innervation has not been explored. Our data show that N-cadherin knockdown in chick trigeminal placode cells decreases trigeminal ganglion size, nerve growth and target innervation in vivo, and reduces neurite complexity of neural crest-derived neurons in vitro. Furthermore, blocking N-cadherin-mediated adhesion prevents axon extension in most placodal neurons in vitro. Collectively, these findings reveal cell- and non-cell autonomous functions for N-cadherin, highlighting its crucial role in mediating reciprocal interactions between neural crest- and placode-derived neurons throughout trigeminal ganglion development.<\/jats:p>","DOI":"10.1242\/dev.204369","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T05:05:33Z","timestamp":1745298333000},"source":"Crossref","is-referenced-by-count":3,"title":["N-cadherin facilitates trigeminal sensory neuron outgrowth and target tissue innervation"],"prefix":"10.1242","volume":"152","author":[{"given":"Caroline A.","family":"Halmi","sequence":"first","affiliation":[{"name":"University of Maryland 1 Department of Animal and Avian Sciences , , College Park, MD 20742 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie E.","family":"Leonard","sequence":"additional","affiliation":[{"name":"University of Maryland 1 Department of Animal and Avian Sciences , , College Park, MD 20742 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alec T.","family":"McIntosh","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center, Georgetown University 2 , Washington, DC 20007 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8630-2514","authenticated-orcid":false,"given":"Lisa A.","family":"Taneyhill","sequence":"additional","affiliation":[{"name":"University of Maryland 1 Department of Animal and Avian Sciences , , College Park, MD 20742 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"2025050105475988900_DEV204369C1","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41592-021-01105-7","article-title":"SNT: a unifying toolbox for quantification of neuronal anatomy","volume":"18","author":"Arshadi","year":"2021","journal-title":"Nat. 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