{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:10:21Z","timestamp":1788282621528,"version":"build-2803163510"},"reference-count":126,"publisher":"The Company of Biologists","issue":"14","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"crossref","award":["KTEF-411281"],"award-info":[{"award-number":["KTEF-411281"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008413","name":"University of Dayton","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008413","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["1RO1EY032959-01"],"award-info":[{"award-number":["1RO1EY032959-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>During development, regulation of gene expression is key to cellular homeostasis. Gene expression regulation by non-coding RNAs involves the prevention of mRNA accumulation or the inhibition of translation of their target gene. In a forward-genetic screen to identify the microRNA involved in the growth and patterning of the Drosophila eye, we identified the highly conserved miR-137. Gain of function of miR-137 results in a reduced-eye phenotype by downregulating retinal determination and differentiation markers, and by upregulating negative regulators of eye development, such as Wingless (Wg) and Homothorax (Hth). Loss of function of miR-137 results in an enlarged-eye phenotype. Using bioinformatics and genetic approaches, we identified the oncogene Myc as the target of miR-137. Gain of function of Myc can rescue the reduced-eye phenotype of miR-137 gain of function, and vice versa. We tested the role of miR-137 in regulating Myc levels in the RasV12;scribRNAi, a tumor model of oncogenic cooperation that results in neoplastic tumors. Gain of function of miR-137 in the RasV12;scribRNAi background significantly reduced tumor phenotype as well as Myc levels in the eye. Our studies highlight miR-137 as a post-transcriptional regulator of Myc and a promising therapeutic target for diseases associated with Myc accumulation.<\/jats:p>","DOI":"10.1242\/dev.204373","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T16:29:14Z","timestamp":1750782554000},"source":"Crossref","is-referenced-by-count":6,"title":["<i>miR-137<\/i> targets <i>Myc<\/i> to regulate growth during eye development"],"prefix":"10.1242","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5064-0706","authenticated-orcid":false,"given":"Radhika","family":"Padma","sequence":"first","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3341-3739","authenticated-orcid":false,"given":"Manivannan","family":"Subramanian","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-7404","authenticated-orcid":false,"given":"Anuradha Venkatakrishnan","family":"Chimata","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4071-4446","authenticated-orcid":false,"given":"Arushi","family":"Rai","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8058-2087","authenticated-orcid":false,"given":"Sunanda","family":"Yogi","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-5013","authenticated-orcid":false,"given":"Anjali","family":"Sangeeth","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2447-6997","authenticated-orcid":false,"given":"Madhuri","family":"Kango-Singh","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]},{"name":"University of Dayton 2 Premedical Program , , Dayton, OH 45469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-2255","authenticated-orcid":false,"given":"Amit","family":"Singh","sequence":"additional","affiliation":[{"name":"University of Dayton 1 Department of Biology , , Dayton, OH 45469 ,","place":["USA"]},{"name":"University of Dayton 2 Premedical Program , , Dayton, OH 45469 ,","place":["USA"]},{"name":"Center for Genomic Advocacy (TCGA), Indiana State University 3 , Terre Haute, IN 47809,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"2025071605144031900_DEV204373C1","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1002\/ijc.28091","article-title":"MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A","volume":"133","author":"Althoff","year":"2013","journal-title":"Int. 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