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They robustly secrete Reln, a glycoprotein essential for the establishment of cortical layers through the control of radial migration. We previously identified Gmnc as a crucial fate determinant for P73+ CR subtypes. In Gmnc\u2212\/\u2212 mutants, P73+ CRs are initially produced and cover the telencephalic vesicle but undergo massive apoptosis resulting in their complete depletion at mid-corticogenesis. Here, we investigated the consequences of such a CR depletion on dorsal cortex lamination and hippocampal morphogenesis. We found that preplate splitting normally occurs in Gmnc\u2212\/\u2212 mutants but is followed by defective radial migration arrest in the dorsal cortex, an altered cellular organization in the lateral cortex, aberrant hippocampal CA1 folding and lack of vasculature development in the hippocampal fissure. We then performed conditional Reln deletion in P73+ CRs to evaluate its relative contribution and found that only radial migration defects were recapitulated. We concluded that at mid-corticogenesis, CR-derived Reln is required for radial migration arrest and additionally identified Reln-independent functions for CRs in the control of hippocampal fissure formation and CA1 folding.<\/jats:p>","DOI":"10.1242\/dev.204451","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:44:51Z","timestamp":1744263891000},"source":"Crossref","is-referenced-by-count":2,"title":["Differential contribution of P73+ Cajal-Retzius cells and Reelin to cortical morphogenesis"],"prefix":"10.1242","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-1782","authenticated-orcid":false,"given":"Vicente","family":"Elorriaga","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266 1 , F-75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3292-5049","authenticated-orcid":false,"given":"Beno\u00eet","family":"Bouloudi","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l'Ecole Normale Sup\u00e9rieure (IBENS), Ecole Normale Sup\u00e9rieure, CNRS, INSERM, Universit\u00e9 PSL 3 , 75005 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6495-1051","authenticated-orcid":false,"given":"Elodie","family":"Delberghe","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266 1 , F-75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris 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Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1336-065X","authenticated-orcid":false,"given":"Patrick","family":"Azzam","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266 1 , F-75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-2373","authenticated-orcid":false,"given":"Matthieu X.","family":"Moreau","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266 1 , F-75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-6806","authenticated-orcid":false,"given":"Rolf","family":"Stottmann","sequence":"additional","affiliation":[{"name":"Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital 4 , Columbus, OH 43205 ,","place":["USA"]},{"name":"The Ohio State University College of Medicine 5 Department of Pediatrics , , Columbus, OH 43210 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5352-0929","authenticated-orcid":false,"given":"Nadia","family":"Bahi-Buisson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4872-4791","authenticated-orcid":false,"given":"Alessandra","family":"Pierani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris, INSERM U1266 1 , F-75014 Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9, Imagine Institute, Team Genetics and Development of the Cerebral Cortex 2 , F-75015 Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-6464","authenticated-orcid":false,"given":"Nathalie","family":"Spassky","sequence":"additional","affiliation":[{"name":"Institut de Biologie de l'Ecole Normale Sup\u00e9rieure (IBENS), Ecole Normale Sup\u00e9rieure, CNRS, INSERM, Universit\u00e9 PSL 3 , 75005 Paris 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