{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:02:33Z","timestamp":1787313753156,"version":"build-2736575974"},"reference-count":56,"publisher":"The Company of Biologists","issue":"13","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01 DK125895"],"award-info":[{"award-number":["R01 DK125895"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["R01 HL122578"],"award-info":[{"award-number":["R01 HL122578"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HL173766"],"award-info":[{"award-number":["HL173766"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006537","name":"Vanderbilt University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006537","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mutations in ANG2 and TIE1 are associated with primary lymphedema in humans, but the mechanisms of ANG\/TIE signaling in the lymphatic vasculature remain incompletely understood. We document that TIE2 is not detected in lymphatic endothelial cells (LECs) before E14.5 but is expressed in collecting vessels from later embryonic stages, in contrast to robust TIE1 expression in all LECs from early stages. Accordingly, only LEC-specific deletion of Tie1 but not Tie2 resulted in defective lymphatic development and abnormal valve function. We discovered that defects of Tie1 lymphatic knockout mice were largely rescued by simultaneous loss of Foxo1. In addition, FOXC2 expression was abolished in Tie1-deficient lymphatics but restored by simultaneous loss of Foxo1, indicating that FOXO1, regulating FOXC2, might be a direct downstream effector of TIE1 signaling in the lymphatic system. Further, we generated point mutations in each tyrosine kinase domain of TIE1 and found that the second, but not the first, tyrosine kinase domain of TIE1 is essential for its function in the lymphatic system. Thus, our results suggest new avenues for manipulation of TIE1 signaling to enhance therapeutic lymphangiogenesis.<\/jats:p>","DOI":"10.1242\/dev.204469","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T12:33:01Z","timestamp":1749817981000},"source":"Crossref","is-referenced-by-count":6,"title":["TIE1-dependent lymphatic vascular remodeling is mediated by its second tyrosine kinase domain"],"prefix":"10.1242","volume":"152","author":[{"given":"H. Scott","family":"Baldwin","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center 1 Department of Pediatrics (Cardiology) , , Nashville, TN 37232 ,","place":["USA"]},{"name":"Vanderbilt University 2 Department of Cell and Development Biology , , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Davis","sequence":"additional","affiliation":[{"name":"University of Missouri 3 Department of Medical Pharmacology and Physiology , , Columbia, MO 65212 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Harmelink","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center 1 Department of Pediatrics (Cardiology) , , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-812X","authenticated-orcid":false,"given":"Xianghu","family":"Qu","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center 1 Department of Pediatrics (Cardiology) , , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"2025062709030968900_DEV204469C1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1101\/gad.13.3.295","article-title":"Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial\/venous domains, vascular morphogenesis, and sprouting angiogenesis","volume":"13","author":"Adams","year":"1999","journal-title":"Genes Dev."},{"key":"2025062709030968900_DEV204469C2","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nm.2545","article-title":"The lymphatic vasculature in disease","volume":"17","author":"Alitalo","year":"2011","journal-title":"Nat. Med."},{"key":"2025062709030968900_DEV204469C3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/nrm2639","article-title":"Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system","volume":"10","author":"Augustin","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025062709030968900_DEV204469C4","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1172\/JCI58050","article-title":"Genes regulating lymphangiogenesis control venous valveformation and maintenance in mice","volume":"121","author":"Bazigou","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C5","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/nprot.2016.092","article-title":"High-resolution 3D analysis of mouse small-intestinal stroma","volume":"11","author":"Bernier-Latmani","year":"2016","journal-title":"Nat. Protoc."},{"key":"2025062709030968900_DEV204469C6","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nrgastro.2017.79","article-title":"Intestinal lymphatic vasculature: structure, mechanisms and functions","volume":"14","author":"Bernier-Latmani","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2025062709030968900_DEV204469C7","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.1172\/JCI82045","article-title":"DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport","volume":"125","author":"Bernier-Latmani","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C8","doi-asserted-by":"publisher","first-page":"e173586","DOI":"10.1172\/JCI173586","article-title":"Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema","volume":"134","author":"Brouillard","year":"2024","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C9","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1182\/blood-2010-07-298562","article-title":"Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome basedtransgenic mouse","volume":"117","author":"Choi","year":"2011","journal-title":"Blood"},{"key":"2025062709030968900_DEV204469C10","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1101\/gad.1189704","article-title":"Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)","volume":"18","author":"Daly","year":"2004","journal-title":"Genes Dev."},{"key":"2025062709030968900_DEV204469C11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1161\/ATVBAHA.109.196618","article-title":"Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report","volume":"30","author":"D'Amico","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2025062709030968900_DEV204469C12","doi-asserted-by":"publisher","first-page":"H48","DOI":"10.1152\/ajpheart.00133.2011","article-title":"Determinants of valve gating in collecting lymphatic vessels from rat mesentery","volume":"301","author":"Davis","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2025062709030968900_DEV204469C13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ydbio.2008.04.024","article-title":"Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice","volume":"319","author":"Dellinger","year":"2008","journal-title":"Dev. Biol."},{"key":"2025062709030968900_DEV204469C14","doi-asserted-by":"publisher","first-page":"e176577","DOI":"10.1172\/JCI176577","article-title":"The mechanosensory channel PIEZO1 functions upstream of angiopoietin\/TIE\/FOXO1 signaling in lymphatic development","volume":"134","author":"Du","year":"2024","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C15","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1101\/gad.8.16.1897","article-title":"Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo","volume":"8","author":"Dumont","year":"1994","journal-title":"Genes Dev."},{"key":"2025062709030968900_DEV204469C16","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1042\/CS20160129","article-title":"Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems","volume":"131","author":"Eklund","year":"2017","journal-title":"Clin. Sci."},{"key":"2025062709030968900_DEV204469C17","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","article-title":"Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1","volume":"3","author":"Gale","year":"2002","journal-title":"Dev. Cell"},{"key":"2025062709030968900_DEV204469C18","doi-asserted-by":"publisher","first-page":"e82969","DOI":"10.7554\/eLife.82969","article-title":"Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner","volume":"12","author":"Hu\u00dfmann","year":"2023","journal-title":"eLife"},{"key":"2025062709030968900_DEV204469C19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s12276-018-0037-x","article-title":"Multiple sgRNAs with overlapping sequences enhance CRISPR\/Cas9-mediated knock-in efficiency","volume":"50","author":"Jang","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"2025062709030968900_DEV204469C20","doi-asserted-by":"publisher","first-page":"dev193029","DOI":"10.1242\/dev.193029","article-title":"Tek (Tie2) is not required for cardiovascular development in zebrafish","volume":"147","author":"Jiang","year":"2020","journal-title":"Development"},{"key":"2025062709030968900_DEV204469C21","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1002\/dvdy.21200","article-title":"Lymphatic development in mouse small intestine","volume":"236","author":"Kim","year":"2007","journal-title":"Dev. Dyn."},{"key":"2025062709030968900_DEV204469C22","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1128\/MCB.22.6.1704-1713.2002","article-title":"The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis","volume":"22","author":"Kontos","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"2025062709030968900_DEV204469C23","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1172\/JCI84923","article-title":"Tie1 controls angiopoietin function in vascular remodeling and inflammation","volume":"126","author":"Korhonen","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C24","doi-asserted-by":"publisher","first-page":"e155478","DOI":"10.1172\/JCI155478","article-title":"Lymphangiogenesis requires Ang2\/Tie\/PI3K signaling for VEGFR3 cell-surface expression","volume":"132","author":"Korhonen","year":"2022","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C25","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1172\/JCI89607","article-title":"RASA1 regulates the function of lymphatic vessel valves in mice","volume":"127","author":"Lapinski","year":"2017","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C26","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1073\/pnas.1616166114","article-title":"Structural basis of Tie2 activation and Tie2\/Tie1 heterodimerization","volume":"114","author":"Leppanen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025062709030968900_DEV204469C27","doi-asserted-by":"publisher","first-page":"eaax8013","DOI":"10.1126\/scitranslmed.aax8013","article-title":"Characterization of ANGPT2 mutations associated with primary lymphedema","volume":"12","author":"Leppanen","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"2025062709030968900_DEV204469C28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/ng.272","article-title":"Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations","volume":"41","author":"Limaye","year":"2009","journal-title":"Nat. Genet."},{"key":"2025062709030968900_DEV204469C29","doi-asserted-by":"publisher","first-page":"30509","DOI":"10.1074\/jbc.M702535200","article-title":"Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2","volume":"282","author":"Marron","year":"2007","journal-title":"J. Biol. Chem"},{"key":"2025062709030968900_DEV204469C30","doi-asserted-by":"publisher","first-page":"6780","DOI":"10.3390\/ijms21186780","article-title":"TIE1 as a candidate gene for lymphatic malformations with or without lymphedema","volume":"21","author":"Michelini","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2025062709030968900_DEV204469C31","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/nprot.2017.153","article-title":"Easi-CRISPR for creating knock-in and conditional knockout mouse models using long ssDNA donors","volume":"13","author":"Miura","year":"2018","journal-title":"Nat. Protoc."},{"key":"2025062709030968900_DEV204469C32","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1161\/CIRCRESAHA.116.308825","article-title":"Polydom is an extracellular matrix protein involved in lymphatic vessel remodeling","volume":"120","author":"Morooka","year":"2017","journal-title":"Circ. Res."},{"key":"2025062709030968900_DEV204469C33","doi-asserted-by":"publisher","first-page":"dev202269","DOI":"10.1242\/dev.202269","article-title":"Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish","volume":"151","author":"Morooka","year":"2024","journal-title":"Development"},{"key":"2025062709030968900_DEV204469C34","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1172\/JCI71608","article-title":"New developments in clinical aspects of lymphatic disease","volume":"124","author":"Mortimer","year":"2014","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C35","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1172\/JCI89963","article-title":"Tie1: an orphan receptor provides context for angiopoietin-2\/Tie2 signaling","volume":"126","author":"Mueller","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ydbio.2016.11.017","article-title":"Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43","volume":"421","author":"Munger","year":"2017","journal-title":"Dev. Biol."},{"key":"2025062709030968900_DEV204469C37","doi-asserted-by":"publisher","first-page":"6374","DOI":"10.1093\/hmg\/ddv349","article-title":"Common and specific effects of TIE2 mutations causing venous malformations","volume":"24","author":"Natynki","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2025062709030968900_DEV204469C39","doi-asserted-by":"publisher","first-page":"110048","DOI":"10.1016\/j.celrep.2021.110048","article-title":"FOXO1 represses lymphatic valve formation and maintenance via PRDM1","volume":"37","author":"Niimi","year":"2021","journal-title":"Cell Rep."},{"key":"2025062709030968900_DEV204469C40","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.cell.2020.06.039","article-title":"The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease","volume":"182","author":"Oliver","year":"2020","journal-title":"Cell"},{"key":"2025062709030968900_DEV204469C41","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","article-title":"FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis","volume":"128","author":"Paik","year":"2007","journal-title":"Cell"},{"key":"2025062709030968900_DEV204469C42","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1172\/JCI23126","article-title":"Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization","volume":"115","author":"Potente","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C43","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1242\/dev.043380","article-title":"Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice","volume":"137","author":"Qu","year":"2010","journal-title":"Development"},{"key":"2025062709030968900_DEV204469C44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ydbio.2014.12.021","article-title":"Tie1 is required for lymphatic valve and collecting vessel development","volume":"399","author":"Qu","year":"2015","journal-title":"Dev. Biol."},{"key":"2025062709030968900_DEV204469C45","doi-asserted-by":"publisher","first-page":"96002","DOI":"10.1172\/jci.insight.96002","article-title":"Tie2 regulates endocardial sprouting and myocardial trabeculation","volume":"4","author":"Qu","year":"2019","journal-title":"JCI Insight"},{"key":"2025062709030968900_DEV204469C46","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1172\/JCI80454","article-title":"FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature","volume":"125","author":"Sabine","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C47","doi-asserted-by":"publisher","first-page":"9355","DOI":"10.1073\/pnas.90.20.9355","article-title":"Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system","volume":"90","author":"Sato","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025062709030968900_DEV204469C48","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.celrep.2015.08.024","article-title":"The orphan receptor Tie1 controls angiogenesis and vascular remodeling by differentially regulating Tie2 in tip and stalk cells","volume":"12","author":"Savant","year":"2015","journal-title":"Cell Rep"},{"key":"2025062709030968900_DEV204469C49","doi-asserted-by":"publisher","first-page":"e142341","DOI":"10.1172\/JCI142341","article-title":"Foxo1 deletion promotes the growth of new lymphatic valves","volume":"131","author":"Scallan","year":"2021","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C50","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.molcel.2010.02.007","article-title":"Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands","volume":"37","author":"Seegar","year":"2010","journal-title":"Mol. Cell"},{"key":"2025062709030968900_DEV204469C51","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1161\/ATVBAHA.113.302923","article-title":"Genetic dissection of tie pathway in mouse lymphatic maturation and valve development","volume":"34","author":"Shen","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol"},{"key":"2025062709030968900_DEV204469C52","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1172\/JCI85830","article-title":"Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity","volume":"126","author":"Souma","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C53","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1073\/pnas.1714446115","article-title":"Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP","volume":"115","author":"Souma","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025062709030968900_DEV204469C54","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1172\/JCI79386","article-title":"Lymph flow regulates collecting lymphatic vessel maturation in vivo","volume":"125","author":"Sweet","year":"2015","journal-title":"J. Clin. Invest."},{"key":"2025062709030968900_DEV204469C55","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature16498","article-title":"FOXO1 couples metabolic activity and growth state in the vascular endothelium","volume":"529","author":"Wilhelm","year":"2016","journal-title":"Nature"},{"key":"2025062709030968900_DEV204469C56","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.cell.2012.10.023","article-title":"Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling","volume":"151","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"2025062709030968900_DEV204469C57","doi-asserted-by":"publisher","first-page":"45276","DOI":"10.1074\/jbc.M208063200","article-title":"Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear\/cytoplasmic shuttling and DNA binding","volume":"277","author":"Zhang","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204469\/3652501\/dev204469.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204469\/3654293\/dev204469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204469\/3654293\/dev204469.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T09:03:58Z","timestamp":1751015038000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/152\/13\/dev204469\/368425\/TIE1-dependent-lymphatic-vascular-remodeling-is"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":56,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.204469","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"article-number":"dev204469"}}