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VHL mutations show highly vascularized tumor across various organs due to HIF activation and upregulation of HIF-target genes such as VEGF in non-endothelial cells (ECs), influencing neighboring ECs and triggering abnormal angiogenesis. Whether VHL mutations in ECs also contribute to abnormal angiogenesis remains unclear. To address this question, we utilized a well-characterized skin vasculature model that encompasses the processes of vascular patterning and arterial\/venous development, to investigate vascular development in mice with an EC-specific Vhl deletion. The mutants exhibited abnormal vascular network formation and embryonic lethal. Mechanistically, the Vhl deletion led to ectopic expression of the chemokine receptor CXCR4 through HIF stabilization in ECs. Treatment with AMD3100, a CXCR4 antagonist, partially restored vascular abnormalities caused by Vhl deletion in ECs. Additionally, publicly available single-cell RNA-sequencing data from ECs of individuals with VHL syndrome supports our findings, indicating that VHL mutations in ECs contribute to abnormal angiogenesis through ectopic activation of the HIF-CXCR4 signaling axis.<\/jats:p>","DOI":"10.1242\/dev.204519","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:03:39Z","timestamp":1776672219000},"source":"Crossref","is-referenced-by-count":0,"title":["Endothelial von Hippel-Lindau gene deletion causes abnormal blood and lymphatic vasculature through ectopic activation of the HIF-CXCR4 axis"],"prefix":"10.1242","volume":"153","author":[{"given":"Wenling","family":"Li","sequence":"first","affiliation":[{"name":"Cell and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health 1 Laboratory of Stem Cell and Neuro-Vascular Biology , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Nakayama","sequence":"additional","affiliation":[{"name":"School of Medicine, Asahikawa Medical University 2 Department of Pharmacology , , Asahikawa, Hokkaido 078-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Sato","sequence":"additional","affiliation":[{"name":"Cell and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health 1 Laboratory of Stem Cell and Neuro-Vascular Biology , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Shimada","sequence":"additional","affiliation":[{"name":"Cell and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health 1 Laboratory of Stem Cell and Neuro-Vascular Biology , , Bethesda, MD 20892 ,","place":["USA"]},{"name":"Graduate School of Medicine, Tohoku University 3 Department of Organ Anatomy , , Aoba-ku, Sendai, Miyagi 980-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Kubota","sequence":"additional","affiliation":[{"name":"Keio University School of Medicine 4 Department of Anatomy , , Shinanomachi, Shinjuku-ku, Tokyo 160-8582 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-4922","authenticated-orcid":false,"given":"Yoh-suke","family":"Mukouyama","sequence":"additional","affiliation":[{"name":"Cell and Development Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health 1 Laboratory of Stem Cell and Neuro-Vascular Biology , , Bethesda, MD 20892 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2026060111284300700_DEV204519C1","doi-asserted-by":"publisher","first-page":"e92193","DOI":"10.1172\/jci.insight.92193","article-title":"Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch","volume":"3","author":"Arreola","year":"2018","journal-title":"JCI Insight"},{"key":"2026060111284300700_DEV204519C2","doi-asserted-by":"publisher","first-page":"3955","DOI":"10.3390\/ijms22083955","article-title":"Mechanosensation and mechanotransduction by lymphatic endothelial cells act as important regulators of lymphatic development and function","volume":"22","author":"Balint","year":"2021","journal-title":"Int. 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