{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:34:25Z","timestamp":1790667265414,"version":"4.1.0"},"reference-count":209,"publisher":"The Company of Biologists","issue":"6","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-23-CE14-0012 HeteroSex"],"award-info":[{"award-number":["ANR-23-CE14-0012 HeteroSex"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-24-CE14-2476 Anaform"],"award-info":[{"award-number":["ANR-24-CE14-2476 Anaform"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Sex determination and differentiation are fundamental processes that are not only essential for fertility but also influence the development of many other organs, and hence, are important for species diversity and survival. In mammals, sex is determined by the inheritance of an X or a Y chromosome from the father. The Y chromosome harbours the testis-determining gene SRY, and it has long been thought that its absence is sufficient for ovarian development. Consequently, the ovarian pathway has been treated as a default pathway, in the sense that ovaries do not have or need a female-determining factor. Recently, a female-determining factor has been identified in mouse as the master regulator of ovarian development. Interestingly, this scenario was predicted as early as 1983. In this Review, we discuss the model predicted in 1983, how the mechanisms and genes currently known to be important for sex determination and differentiation in mammals have changed or supported this model, and finally, reflect on what these findings might mean for sex determination in other vertebrates.<\/jats:p>","DOI":"10.1242\/dev.204592","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:29:38Z","timestamp":1743427778000},"source":"Crossref","is-referenced-by-count":19,"title":["Gonadal sex determination in vertebrates: rethinking established mechanisms"],"prefix":"10.1242","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-4075","authenticated-orcid":false,"given":"Dagmar","family":"Wilhelm","sequence":"first","affiliation":[{"name":"The University of Melbourne 1 Department of Anatomy and Physiology , , Melbourne, VIC 3010 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aitana","family":"Perea-Gomez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, INSERM, CNRS, Institut de Biologie Valrose (iBV) 2 , 06108 Nice ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Newton","sequence":"additional","affiliation":[{"name":"The School of BioSciences, University of Melbourne 3 TIGRR Lab , , Melbourne, VIC 3010 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0934-8217","authenticated-orcid":false,"given":"Marie-Christine","family":"Chaboissier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te d'Azur, INSERM, CNRS, Institut de Biologie Valrose (iBV) 2 , 06108 Nice ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"2025033107295071200_DEV204592C1","doi-asserted-by":"publisher","first-page":"110935","DOI":"10.1016\/j.celrep.2022.110935","article-title":"Deciphering the origins and fates of steroidogenic lineages in the mouse testis","volume":"39","author":"Ademi","year":"2022","journal-title":"Cell Rep."},{"key":"2025033107295071200_DEV204592C2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ygcen.2008.03.018","article-title":"Molecular cloning and quantitative expression of sexually dimorphic markers Dmrt1 and Foxl2 during female-to-male sex change in Epinephelus merra","volume":"157","author":"Alam","year":"2008","journal-title":"Gen. 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