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A unifying spatiotemporal motif might link sensory, central and motor populations that comprise an entire circuit. In the sensorimotor reflex circuit that stabilizes vertebrate gaze, central and motor partners are paired in time (birthdate) and space (dorsoventral). To determine if birthdate and\/or dorsoventral organization could align the entire circuit, we measured the spatial and temporal development of the sensory circuit node: the vestibular ganglion neurons. We discovered that progressive dorsal-to-ventral organization closely predicts vestibular ganglion development, with additional organization along its functional (rostrocaudal) axis. With an acute optical lesion and calcium imaging paradigm, we found that this common temporal axis anticipated functional sensory-to-central partner matching. We propose a \u2018first-come, first-served\u2019 model, in which birthdate organizes and assembles the sensory, central and motor populations that comprise the gaze stabilization circuit, a general strategy for polysynaptic circuit assembly across embryonically diverse neural populations.<\/jats:p>","DOI":"10.1242\/dev.204616","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:39:52Z","timestamp":1768894792000},"source":"Crossref","is-referenced-by-count":4,"title":["Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0609-1655","authenticated-orcid":false,"given":"Stephanie","family":"Huang","sequence":"first","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]},{"name":"Center for Neural Science, New York University 2 , New York, NY 10003 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4732-4340","authenticated-orcid":false,"given":"Emily","family":"Gershowitz","sequence":"additional","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-7566","authenticated-orcid":false,"given":"Marie R.","family":"Greaney","sequence":"additional","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-9480","authenticated-orcid":false,"given":"Samantha N.","family":"Davis","sequence":"additional","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7969-9632","authenticated-orcid":false,"given":"David","family":"Schoppik","sequence":"additional","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0333-2433","authenticated-orcid":false,"given":"Dena","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"the Institute for Translational Neuroscience, NYU Grossman School of Medicine 1 Departments of Neuroscience, Otolaryngology , and , New York, NY 10016 ,","place":["USA"]},{"name":"Center for Neural Science, New York University 2 , New York, NY 10003 ,","place":["USA"]},{"name":"Spinal Circuits and Plasticity Unit, National Institute of Neurological Disorders and Stroke 3 , Bethesda, MD 20814 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2026021905003016200_DEV204616C1","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/cne.901980409","article-title":"Development of the brain stem in the rat. 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