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Central to these interactions is the IPP complex, a heterotrimeric assembly of Pinch (\u2018particularly interesting new cysteine-histidine-rich\u2019) proteins, integrin-linked kinase (Ilk) and parvins, which serves as a crucial signaling hub linking integrins to diverse cellular pathways. Through Schwann cell-specific conditional gene ablation in mice, we reveal distinct and essential roles for Pinch1 and Pinch2 in Schwann cell function. While Pinch1 is primarily required for proper radial sorting of axons and maturation of Remak bundles, Pinch2 modulates myelin thickness and is crucial for effective remyelination following sciatic nerve injury. Our data suggest that Pinch1-mediated specific modulation of Rho GTPase signaling is essential for sorting of axon bundles, and that Pinch2 likely modulates RhoA to relieve its inhibitory effect on myelination and remyelination. These findings support a dual intrinsic function of the IPP complex regulating active Rho GTPase signaling, shedding light on the molecular mechanisms underlying developmental peripheral nervous system myelination and repair.<\/jats:p>","DOI":"10.1242\/dev.204677","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:53:11Z","timestamp":1775119991000},"source":"Crossref","is-referenced-by-count":0,"title":["Pinch-mediated signaling controls myelination and remyelination in the peripheral nervous system"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7046-6197","authenticated-orcid":false,"given":"Joana","family":"Paes-de-Faria","sequence":"first","affiliation":[{"name":"Glial Cell Biology Group, i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto 1 , 4200-135 Porto ,","place":["Portugal"]},{"name":"Glial Cell Biology Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , 4200-135 Porto ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno Gon\u00e7alo","family":"Dias","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Group, i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto 1 , 4200-135 Porto ,","place":["Portugal"]},{"name":"Glial Cell Biology Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , 4200-135 Porto ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Filipa","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , 4200-135 Porto ,","place":["Portugal"]},{"name":"Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Z\u00fcrich 3 Department of Biology , , Z\u00fcrich 8093 ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"F\u00e4ssler","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Max Planck Institute of Biochemistry 4 , 82152 Martinsried ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-0924","authenticated-orcid":false,"given":"Jo\u00e3o Bettencourt","family":"Relvas","sequence":"additional","affiliation":[{"name":"Glial Cell Biology Group, i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto 1 , 4200-135 Porto ,","place":["Portugal"]},{"name":"Glial Cell Biology Group, IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto 2 , 4200-135 Porto ,","place":["Portugal"]},{"name":"Faculdade de Medicina da Universidade do Porto 5 Departamento de Biomedicina - Unidade de Biologia Experimental , , 4200- 319 Porto ,","place":["Portugal"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"2026040204530545100_DEV204677C1","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1084\/jem.20161714","article-title":"GPR56\/ADGRG1 regulates development and maintenance of peripheral myelin","volume":"215","author":"Ackerman","year":"2018","journal-title":"J. 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