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Kr\u00fcppel-like factor 7 (KLF7), a transcription factor associated with autism spectrum disorder and intellectual developmental disorders, plays a pivotal role in brain development. In this study, we investigated the role of KLF7 in hippocampal development using conditional knockout mice [Emx1-Cre;Klf7Flox(F)\/F]. We found that KLF7 deletion in hippocampal progenitors resulted in significant hippocampal shrinkage, disrupting neurogenesis, neuronal differentiation and migration. KLF7 mutant mice exhibited abnormal neuronal projections, anxiety- and depression-like behaviors, and memory impairments. Transcriptomic profiling identified Draxin, a neural chemorepellent, as a key downstream target of KLF7. Remarkably, overexpression of Draxin rescued dentate gyrus granule cell migration defects in KLF7 mutant mice. These findings demonstrate that KLF7 is essential for proper hippocampal development and function, regulating neuronal migration through Draxin. This study provides mechanistic insights into the neurological deficits associated with KLF7 pathogenic variants and highlights potential therapeutic targets for neurodevelopmental disorders.<\/jats:p>","DOI":"10.1242\/dev.204718","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T13:00:07Z","timestamp":1754398807000},"source":"Crossref","is-referenced-by-count":2,"title":["KLF7 orchestrates hippocampal development through neurogenesis and Draxin-mediated neuronal migration"],"prefix":"10.1242","volume":"152","author":[{"given":"Yitong","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Basic Medical Sciences, Bengbu Medical University 2 , Bengbu, 233030 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Basic Medical Sciences, Anhui Medical University 3 , Hefei, 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pifang","family":"Gong","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guibo","family":"Qi","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Song","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenru","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanming","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Basic Medical Sciences, Anhui Medical University 3 , Hefei, 230032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Qi","sequence":"additional","affiliation":[{"name":"Fudan University 4 Department of Laboratory Animal Science , , Shanghai, 200032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-4324","authenticated-orcid":false,"given":"Song","family":"Qin","sequence":"additional","affiliation":[{"name":"Shanghai Pudong Hospital 1 Department of Neurology , and Department of Histoembryology , , Shanghai, 200032 ,","place":["China"]},{"name":"School of 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