{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:35:24Z","timestamp":1766046924149,"version":"3.48.0"},"reference-count":89,"publisher":"The Company of Biologists","issue":"24","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["GM118447"],"award-info":[{"award-number":["GM118447"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tissue maintenance in the presence of cell death-promoting insults requires a host of molecular mechanisms. Many studies focus on cell renewal through regeneration, while fewer studies explore mechanisms that promote cell longevity despite cell death stimuli. Here, we reveal that the adult Drosophila hindgut ileum is an excellent model for studying tissue maintenance by long-lived cells. Hindgut ileal enterocytes resist the damaging detergent SDS and upstream caspase signaling by head-involution-defective (hid). This hid-induced death insensitivity arises early in adulthood and is associated with numerous transcriptional changes. We interrogated 82 of these transcriptional changes in a candidate screen for enhancers of hid-induced death in the ileum. Top among our screen hits is an immunoglobulin family cell adhesion gene, CG15312, that maintains the adhesion protein FasIII on cell membranes. In hid-expressing ileal cells, CG15312 loss causes cell death and pyknotic nuclear clustering. We name this conserved gene low on-membrane fas and enhancer of hid (loofah). Our findings reveal a new mechanism linking cell adhesion and cell death resistance in a long-lived cell type. Our work establishes a new model for studying tissue preservation.<\/jats:p>","DOI":"10.1242\/dev.204835","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:29:46Z","timestamp":1766046586000},"source":"Crossref","is-referenced-by-count":0,"title":["Loofah suppresses cell death in long-lived\n                    <i>Drosophila<\/i>\n                    hindgut enterocytes"],"prefix":"10.1242","volume":"152","author":[{"given":"Jessica K.","family":"Sawyer","sequence":"first","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth A.","family":"Montague","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob W.","family":"Klemm","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Goddard","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Archan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo B.","family":"Belato","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-179X","authenticated-orcid":false,"given":"Donald T.","family":"Fox","sequence":"additional","affiliation":[{"name":"Duke University Department of Pharmacology and Cancer Biology , , Durham, NC 27710 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"2025121803294217300_DEV204835C1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ydbio.2016.10.011","article-title":"Metamorphosis of the Drosophila visceral musculature and its role in intestinal morphogenesis and stem cell formation","volume":"420","author":"Aghajanian","year":"2016","journal-title":"Dev. Biol."},{"key":"2025121803294217300_DEV204835C2","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2008.10.016","article-title":"Tissue damage-induced intestinal stem cell division in Drosophila","volume":"4","author":"Amcheslavsky","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2025121803294217300_DEV204835C3","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/jps.2600820412","article-title":"Epithelial transport of drugs in cell culture. VIII: Effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells","volume":"82","author":"Anderberg","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"2025121803294217300_DEV204835C4","doi-asserted-by":"publisher","first-page":"20883","DOI":"10.1073\/pnas.0911797106","article-title":"Synergy between bacterial infection and genetic predisposition in intestinal dysplasia","volume":"106","author":"Apidianakis","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025121803294217300_DEV204835C5","doi-asserted-by":"publisher","first-page":"e48892","DOI":"10.15252\/embr.201948892","article-title":"Non-apoptotic caspase activation preserves Drosophila intestinal progenitor cells in quiescence","volume":"21","author":"Arthurton","year":"2020","journal-title":"EMBO Rep."},{"key":"2025121803294217300_DEV204835C6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0092-8674(00)80627-3","article-title":"Drosophila p53 binds a damage response element at the reaper locus","volume":"101","author":"Brodsky","year":"2000","journal-title":"Cell"},{"key":"2025121803294217300_DEV204835C7","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1101\/gad.1827009","article-title":"Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila","volume":"23","author":"Buchon","year":"2009","journal-title":"Genes Dev."},{"key":"2025121803294217300_DEV204835C8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chom.2009.01.003","article-title":"Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation","volume":"5","author":"Buchon","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2025121803294217300_DEV204835C9","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.celrep.2013.04.001","article-title":"Morphological and molecular characterization of adult midgut compartmentalization in Drosophila","volume":"3","author":"Buchon","year":"2013","journal-title":"Cell Rep."},{"key":"2025121803294217300_DEV204835C10","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1007\/s00335-023-10015-2","article-title":"The alliance of genome resources: transforming comparative genomics","volume":"34","author":"Bult","year":"2023","journal-title":"Mamm. Genome"},{"key":"2025121803294217300_DEV204835C11","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/nsb989","article-title":"Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination","volume":"10","author":"Chai","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"2025121803294217300_DEV204835C12","doi-asserted-by":"publisher","first-page":"e34063","DOI":"10.1371\/journal.pone.0034063","article-title":"A versatile PhiC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture","volume":"7","author":"Chatterjee","year":"2012","journal-title":"PLoS ONE"},{"key":"2025121803294217300_DEV204835C13","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1101\/gad.10.14.1773","article-title":"grim, a novel cell death gene in Drosophila","volume":"10","author":"Chen","year":"1996","journal-title":"Genes Dev."},{"key":"2025121803294217300_DEV204835C14","doi-asserted-by":"publisher","first-page":"e38327","DOI":"10.7554\/eLife.38327","article-title":"Fizzy-Related dictates A cell cycle switch during organ repair and tissue growth responses in the Drosophila hindgut","volume":"7","author":"Cohen","year":"2018","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1534\/genetics.119.302289","article-title":"Physiology, development, and disease modeling in the drosophila excretory system","volume":"214","author":"Cohen","year":"2020","journal-title":"Genetics"},{"key":"2025121803294217300_DEV204835C16","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1016\/j.devcel.2021.04.029","article-title":"Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut","volume":"56","author":"Cohen","year":"2021","journal-title":"Dev. Cell"},{"key":"2025121803294217300_DEV204835C17","doi-asserted-by":"publisher","first-page":"e41036","DOI":"10.7554\/eLife.41036","article-title":"JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress","volume":"8","author":"Cosolo","year":"2019","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/stem.1503","article-title":"Caspase-3 modulates regenerative response after stroke","volume":"32","author":"Fan","year":"2014","journal-title":"Stem Cells"},{"key":"2025121803294217300_DEV204835C19","doi-asserted-by":"publisher","first-page":"11025","DOI":"10.1073\/pnas.162172899","article-title":"Caspase 3 activity is required for skeletal muscle differentiation","volume":"99","author":"Fernando","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025121803294217300_DEV204835C20","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1083\/jcb.201107133","article-title":"Caspase levels and execution efficiencies determine the apoptotic potential of the cell","volume":"196","author":"Florentin","year":"2012","journal-title":"J. Cell Biol."},{"key":"2025121803294217300_DEV204835C21","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.stem.2009.06.003","article-title":"The Drosophila hindgut lacks constitutively active adult stem cells but proliferates in response to tissue damage","volume":"5","author":"Fox","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2025121803294217300_DEV204835C22","doi-asserted-by":"publisher","first-page":"2294","DOI":"10.1101\/gad.1952710","article-title":"Error-prone polyploid mitosis during normal Drosophila development","volume":"24","author":"Fox","year":"2010","journal-title":"Genes Dev."},{"key":"2025121803294217300_DEV204835C23","doi-asserted-by":"publisher","first-page":"e51716","DOI":"10.15252\/embr.202051716","article-title":"Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells","volume":"24","author":"Galasso","year":"2023","journal-title":"EMBO Rep."},{"key":"2025121803294217300_DEV204835C24","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1038\/s41467-018-05204-6","article-title":"Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion","volume":"9","author":"Gorelick-Ashkenazi","year":"2018","journal-title":"Nat. Commun."},{"key":"2025121803294217300_DEV204835C25","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1101\/gad.9.14.1694","article-title":"The head involution defective gene of Drosophila melanogaster functions in programmed cell death","volume":"9","author":"Grether","year":"1995","journal-title":"Genes Dev."},{"key":"2025121803294217300_DEV204835C26","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025121803294217300_DEV204835C27","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1242\/dev.120.8.2121","article-title":"Expression of baculovirus P35 prevents cell death in Drosophila","volume":"120","author":"Hay","year":"1994","journal-title":"Development"},{"key":"2025121803294217300_DEV204835C28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.semcdb.2023.05.009","article-title":"The antagonistic relationship between apoptosis and polyploidy in development and cancer","volume":"156","author":"Herriage","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"2025121803294217300_DEV204835C29","doi-asserted-by":"publisher","first-page":"W419","DOI":"10.1093\/nar\/gkad331","article-title":"PANGEA: a new gene set enrichment tool for Drosophila and common research organisms","volume":"51","author":"Hu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2025121803294217300_DEV204835C30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.devcel.2017.01.014","article-title":"An Hdac1\/Rpd3-poised circuit balances continual self-renewal and rapid restriction of developmental potential during asymmetric stem cell division","volume":"40","author":"Janssens","year":"2017","journal-title":"Dev. Cell"},{"key":"2025121803294217300_DEV204835C31","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang","year":"2009","journal-title":"Cell"},{"key":"2025121803294217300_DEV204835C32","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.stem.2010.11.026","article-title":"EGFR\/Ras\/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila","volume":"8","author":"Jiang","year":"2011","journal-title":"Cell Stem Cell"},{"key":"2025121803294217300_DEV204835C33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature24269","article-title":"Transitional basal cells at the squamous-columnar junction generate Barrett's oesophagus","volume":"550","author":"Jiang","year":"2017","journal-title":"Nature"},{"key":"2025121803294217300_DEV204835C34","doi-asserted-by":"publisher","first-page":"RP101114","DOI":"10.7554\/eLife.101114.3","article-title":"Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity","volume":"13","author":"Klemm","year":"2025","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C35","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/s41598-021-81261-0","article-title":"Non-apoptotic enteroblast-specific role of the initiator caspase Dronc for development and homeostasis of the Drosophila intestine","volume":"11","author":"Lindblad","year":"2021","journal-title":"Sci. Rep."},{"key":"2025121803294217300_DEV204835C36","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/j.cub.2013.09.029","article-title":"Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium","volume":"23","author":"Losick","year":"2013","journal-title":"Curr. Biol."},{"key":"2025121803294217300_DEV204835C37","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jgg.2014.10.002","article-title":"No intestinal stem cell regeneration after complete progenitor ablation in Drosophila adult midgut","volume":"42","author":"Lu","year":"2015","journal-title":"J. Genet. Genomics"},{"key":"2025121803294217300_DEV204835C38","doi-asserted-by":"publisher","first-page":"7993","DOI":"10.1038\/srep07993","article-title":"The putative Na(+)\/Cl(-)-dependent neurotransmitter\/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis","volume":"5","author":"Luan","year":"2015","journal-title":"Sci. Rep."},{"key":"2025121803294217300_DEV204835C39","doi-asserted-by":"publisher","first-page":"e76010","DOI":"10.7554\/eLife.76010","article-title":"An improved organ explant culture method reveals stem cell lineage dynamics in the adult Drosophila intestine","volume":"11","author":"Marchetti","year":"2022","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C40","doi-asserted-by":"publisher","first-page":"e00886","DOI":"10.7554\/eLife.00886","article-title":"Physiological and stem cell compartmentalization within the Drosophila midgut","volume":"2","author":"Marianes","year":"2013","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C41","doi-asserted-by":"publisher","first-page":"e36248","DOI":"10.7554\/eLife.36248","article-title":"Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss","volume":"7","author":"Martin","year":"2018","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C42","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/nature04371","article-title":"Evidence that stem cells reside in the adult Drosophila midgut epithelium","volume":"439","author":"Micchelli","year":"2006","journal-title":"Nature"},{"key":"2025121803294217300_DEV204835C43","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1534\/genetics.118.300224","article-title":"Anatomy and physiology of the digestive tract of drosophila melanogaster","volume":"210","author":"Miguel-Aliaga","year":"2018","journal-title":"Genetics"},{"key":"2025121803294217300_DEV204835C44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/(SICI)1097-0177(200005)218:1&lt;52::AID-DVDY5&gt;3.0.CO;2-L","article-title":"Genetic control of epithelial cell polarity: lessons from Drosophila","volume":"218","author":"Muller","year":"2000","journal-title":"Dev. Dyn."},{"key":"2025121803294217300_DEV204835C45","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/jmor.1025","article-title":"Ultrastructure of the hindgut of Drosophila larvae, with special reference to the domains identified by specific gene expression patterns","volume":"248","author":"Murakami","year":"2001","journal-title":"J. Morphol."},{"key":"2025121803294217300_DEV204835C46","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1242\/dev.02495","article-title":"The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process","volume":"133","author":"Muro","year":"2006","journal-title":"Development"},{"key":"2025121803294217300_DEV204835C47","doi-asserted-by":"publisher","first-page":"RP91988","DOI":"10.7554\/eLife.91988.3","article-title":"Extramacrochaetae regulates Notch signaling in the Drosophila eye through non-apoptotic caspase activity","volume":"12","author":"Nair","year":"2024","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C48","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.cell.2011.08.048","article-title":"Altered modes of stem cell division drive adaptive intestinal growth","volume":"147","author":"O'Brien","year":"2011","journal-title":"Cell"},{"key":"2025121803294217300_DEV204835C49","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.jaci.2022.10.020","article-title":"Gut epithelial barrier damage caused by dishwasher detergents and rinse aids","volume":"151","author":"Ogulur","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025121803294217300_DEV204835C50","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/nature04333","article-title":"The adult Drosophila posterior midgut is maintained by pluripotent stem cells","volume":"439","author":"Ohlstein","year":"2006","journal-title":"Nature"},{"key":"2025121803294217300_DEV204835C51","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1074\/jbc.M209734200","article-title":"Reaper is regulated by IAP-mediated ubiquitination","volume":"278","author":"Olson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2025121803294217300_DEV204835C52","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.gene.2014.07.057","article-title":"Rgn gene is required for gut cell homeostasis after ingestion of sodium dodecyl sulfate in Drosophila","volume":"549","author":"Pan","year":"2014","journal-title":"Gene"},{"key":"2025121803294217300_DEV204835C53","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1016\/j.bbamcr.2013.06.026","article-title":"Anoikis molecular pathways and its role in cancer progression","volume":"1833","author":"Paoli","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"2025121803294217300_DEV204835C54","doi-asserted-by":"publisher","first-page":"11","DOI":"10.7554\/eLife.58107","article-title":"Cytoplasmic sharing through apical membrane remodeling","volume":"9","author":"Peterson","year":"2020","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C55","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/j.stem.2024.07.007","article-title":"Hallmarks of regeneration","volume":"31","author":"Poss","year":"2024","journal-title":"Cell Stem Cell"},{"key":"2025121803294217300_DEV204835C56","doi-asserted-by":"publisher","first-page":"40416","DOI":"10.1074\/jbc.M002935200","article-title":"An essential role for the caspase dronc in developmentally programmed cell death in Drosophila","volume":"275","author":"Quinn","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2025121803294217300_DEV204835C57","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3390\/jdb9010011","article-title":"Expanding the junction: new insights into non-occluding roles for septate junction proteins during development","volume":"9","author":"Rice","year":"2021","journal-title":"J. Dev. Biol."},{"key":"2025121803294217300_DEV204835C58","doi-asserted-by":"publisher","first-page":"dev204381","DOI":"10.1242\/dev.204381","article-title":"Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells","volume":"151","author":"Rosa","year":"2024","journal-title":"Development"},{"key":"2025121803294217300_DEV204835C59","doi-asserted-by":"publisher","first-page":"4091","DOI":"10.1101\/152074","article-title":"Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone","volume":"144","author":"Sawyer","year":"2017","journal-title":"Development"},{"key":"2025121803294217300_DEV204835C89","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"2025121803294217300_DEV204835C60","doi-asserted-by":"publisher","first-page":"3551","DOI":"10.1242\/dev.109850","article-title":"Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum","volume":"141","author":"Schoenfelder","year":"2014","journal-title":"Development"},{"key":"2025121803294217300_DEV204835C61","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1038\/ncb1803","article-title":"Regulation of the Drosophila apoptosome through feedback inhibition","volume":"10","author":"Shapiro","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"2025121803294217300_DEV204835C62","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.cub.2010.07.041","article-title":"Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation","volume":"20","author":"Staley","year":"2010","journal-title":"Curr. Biol."},{"key":"2025121803294217300_DEV204835C63","doi-asserted-by":"publisher","first-page":"5270","DOI":"10.1038\/s41467-024-48344-8","article-title":"Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation","volume":"15","author":"Stewart","year":"2024","journal-title":"Nat. Commun."},{"key":"2025121803294217300_DEV204835C64","doi-asserted-by":"publisher","first-page":"e15204","DOI":"10.7554\/eLife.15204","article-title":"Distinct responses to reduplicated chromosomes require distinct Mad2 responses","volume":"5","author":"Stormo","year":"2016","journal-title":"eLife"},{"key":"2025121803294217300_DEV204835C65","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1091\/mbc.E17-10-0582","article-title":"Interphase cohesin regulation ensures mitotic fidelity after genome reduplication","volume":"30","author":"Stormo","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"2025121803294217300_DEV204835C66","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1016\/j.devcel.2025.02.011","article-title":"Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane","volume":"60","author":"Stricker","year":"2025","journal-title":"Dev. Cell"},{"key":"2025121803294217300_DEV204835C67","doi-asserted-by":"publisher","first-page":"e202302238","DOI":"10.26508\/lsa.202302238","article-title":"A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells","volume":"7","author":"Sulekh","year":"2024","journal-title":"Life Sci. Alliance"},{"key":"2025121803294217300_DEV204835C68","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/path.3000","article-title":"Anoikis: an emerging hallmark in health and diseases","volume":"226","author":"Taddei","year":"2012","journal-title":"J. Pathol."},{"key":"2025121803294217300_DEV204835C69","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/nature07156","article-title":"The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling","volume":"454","author":"Takashima","year":"2008","journal-title":"Nature"},{"key":"2025121803294217300_DEV204835C70","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/(SICI)1097-4687(199912)242:3&lt;189::AID-JMOR1&gt;3.0.CO;2-C","article-title":"Light and electron microscopic study of the hindgut of the ant (Formica nigricans, hymenoptera): I. Structure of the ileum","volume":"242","author":"Villaro","year":"1999","journal-title":"J. Morphol."},{"key":"2025121803294217300_DEV204835C71","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jmb.2016.11.027","article-title":"The interconnections between autophagy and integrin-mediated cell adhesion","volume":"429","author":"Vlahakis","year":"2017","journal-title":"J. Mol. Biol."},{"key":"2025121803294217300_DEV204835C72","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.mod.2005.04.003","article-title":"The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals","volume":"122","author":"Waldhuber","year":"2005","journal-title":"Mech. Dev."},{"key":"2025121803294217300_DEV204835C73","doi-asserted-by":"publisher","first-page":"e651","DOI":"10.1038\/cddis.2013.177","article-title":"Protogenin prevents premature apoptosis of rostral cephalic neural crest cells by activating the alpha5beta1-integrin","volume":"4","author":"Wang","year":"2013","journal-title":"Cell Death Dis."},{"key":"2025121803294217300_DEV204835C74","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.devcel.2020.03.015","article-title":"Non-canonical caspase activity antagonizes p38 MAPK stress-priming function to support development","volume":"53","author":"Weaver","year":"2020","journal-title":"Dev. Cell"},{"key":"2025121803294217300_DEV204835C75","doi-asserted-by":"publisher","first-page":"105022","DOI":"10.1016\/j.yrtph.2021.105022","article-title":"Evaluation of the toxicity of sodium dodecyl sulphate (SDS) in the MucilAir human airway model in vitro","volume":"125","author":"Welch","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"2025121803294217300_DEV204835C76","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1016\/j.cub.2006.07.046","article-title":"Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity","volume":"16","author":"Wells","year":"2006","journal-title":"Curr. Biol."},{"key":"2025121803294217300_DEV204835C77","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1126\/science.8171319","article-title":"Genetic control of programmed cell death in Drosophila","volume":"264","author":"White","year":"1994","journal-title":"Science"},{"key":"2025121803294217300_DEV204835C78","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.ydbio.2016.12.020","article-title":"Merkel cells are long-lived cells whose production is stimulated by skin injury","volume":"422","author":"Wright","year":"2017","journal-title":"Dev. Biol."},{"key":"2025121803294217300_DEV204835C79","doi-asserted-by":"publisher","first-page":"15125","DOI":"10.1038\/ncomms15125","article-title":"EGFR-dependent TOR-independent endocycles support Drosophila gut epithelial regeneration","volume":"8","author":"Xiang","year":"2017","journal-title":"Nat. Commun."},{"key":"2025121803294217300_DEV204835C80","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/ncb793","article-title":"Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms","volume":"4","author":"Yoo","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"2025121803294217300_DEV204835C81","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s004410050722","article-title":"Detection of a population of long-lived cells in mammary epithelium of the mouse","volume":"286","author":"Zeps","year":"1996","journal-title":"Cell Tissue Res."},{"key":"2025121803294217300_DEV204835C82","doi-asserted-by":"publisher","first-page":"e1006854","DOI":"10.1371\/journal.pgen.1006854","article-title":"A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila","volume":"13","author":"Zhai","year":"2017","journal-title":"PLoS Genet."},{"key":"2025121803294217300_DEV204835C83","doi-asserted-by":"publisher","first-page":"104114","DOI":"10.1016\/j.ibmb.2024.104114","article-title":"Determination of the larval precursor configuration of the Drosophila adult hindgut by G-TRACE analysis","volume":"168","author":"Zhang","year":"2024","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2025121803294217300_DEV204835C84","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S0960-9822(95)00155-2","article-title":"Programmed cell death in the Drosophila central nervous system midline","volume":"5","author":"Zhou","year":"1995","journal-title":"Curr. Biol."},{"key":"2025121803294217300_DEV204835C85","doi-asserted-by":"publisher","first-page":"5131","DOI":"10.1073\/pnas.94.10.5131","article-title":"Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025121803294217300_DEV204835C86","doi-asserted-by":"publisher","first-page":"e2318760121","DOI":"10.1073\/pnas.2318760121","article-title":"Cellular and molecular organization of the Drosophila foregut","volume":"121","author":"Zhu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025121803294217300_DEV204835C87","doi-asserted-by":"publisher","first-page":"056003","DOI":"10.1088\/1478-3975\/12\/5\/056003","article-title":"A mathematical model for apoptotic switch in Drosophila","volume":"12","author":"Ziraldo","year":"2015","journal-title":"Phys. Biol."},{"key":"2025121803294217300_DEV204835C88","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41556-023-01337-z","article-title":"Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains","volume":"26","author":"Zwick","year":"2024","journal-title":"Nat. Cell Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204835\/3677323\/dev204835.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204835\/3677323\/dev204835.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T08:29:47Z","timestamp":1766046587000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/152\/24\/dev204835\/370142\/Loofah-suppresses-cell-death-in-long-lived"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":89,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2025,12,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.204835","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"type":"print","value":"0950-1991"},{"type":"electronic","value":"1477-9129"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"article-number":"dev204835"}}