{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:50:11Z","timestamp":1793116211662,"version":"4.5.0"},"reference-count":124,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondation de l'H\u00f4pital Maisonneuve-Rosemont"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reprogramming of adult somatic cells into induced pluripotent stem cells (iPSCs) resets the aging clock. However, primed iPSCs can retain cell-of-origin epigenomic marks, especially those linked to heterochromatin. Here, we show that iPSCs produced from fibroblasts of late-onset sporadic Alzheimer's disease (AD) cases retain epigenomic alterations that correlate with developmental anomalies and neurodegeneration. Compared to controls, AD iPSCs show reduced BMI1 expression and H3K9me3 levels and an altered DNA methylome. Gene Ontology analysis of differentially methylated DNA regions reveals terms linked to cell\u2013cell adhesion and synapses, with MEF2C-binding sites being the most enriched at differentially methylated DNA regions. Upon noggin exposure, AD iPSCs show less-efficient neural induction and forebrain specification, together with elevated WNT signaling. Mature AD neurons present a mixed cell lineage identity phenotype and reduced MEF2C expression. AD glial cells express neuronal, cell proliferation, and stem cell-related genes. Despite these anomalies, AD iPSCs generate cortical neurons in normal proportion and readily form cerebral organoids showing AD-related pathologies. These findings implicate reprogramming-resistant epigenomic alterations or genetic variants working in trans on the epigenome in AD pathophysiology.<\/jats:p>","DOI":"10.1242\/dev.204910","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T11:15:55Z","timestamp":1764155755000},"source":"Crossref","is-referenced-by-count":4,"title":["Epigenomic alterations and neural development anomalies in induced pluripotent stem cells from sporadic Alzheimer's disease"],"prefix":"10.1242","volume":"153","author":[{"given":"Alisar","family":"Katbe","sequence":"first","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Hanna","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Flamier","sequence":"additional","affiliation":[{"name":"Centre de Recherche Azrieli du CHU Sainte-Justine 2 Department of Medicine , , Montr\u00e9al, H3T 1C5 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montr\u00e9al 3 Department of Neurosciences , , Montr\u00e9al , H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dounya","family":"Serhani","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimi","family":"Hamam","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Barabino","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tavares","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children 4 Genetics and Genome Biology , , Toronto, M5G 0A4 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lise","family":"H\u00e9on","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children 4 Genetics and Genome Biology , , Toronto, M5G 0A4 ,","place":["Canada"]},{"name":"The Hospital for Sick Children 5 Department of Ophthalmology and Vision Sciences , , Toronto, M5T 3A9 ,","place":["Canada"]},{"name":"Institute of Medical Science, Faculty of Medicine, The University of Toronto 6 , Toronto, M5S 3H2 ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9649-6538","authenticated-orcid":false,"given":"Gilbert","family":"Bernier","sequence":"additional","affiliation":[{"name":"H\u00f4pital Maisonneuve-Rosemont 1 Stem Cell and Developmental Biology Laboratory , , 5690 Boulevard Rosemont, Montr\u00e9al, H1T 2H2 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montr\u00e9al 3 Department of Neurosciences , , Montr\u00e9al , H3T 1J4,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"2026090107113423500_DEV204910C1","doi-asserted-by":"publisher","first-page":"8884","DOI":"10.1523\/JNEUROSCI.0968-09.2009","article-title":"BMI1 sustains human glioblastoma multiforme stem cell renewal","volume":"29","author":"Abdouh","year":"2009","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C2","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1074\/jbc.M115.662403","article-title":"The polycomb repressive complex 1 protein BMI1 is required for constitutive heterochromatin formation and silencing in mammalian somatic cells","volume":"291","author":"Abdouh","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2026090107113423500_DEV204910C3","doi-asserted-by":"publisher","first-page":"100065","DOI":"10.1016\/j.nbas.2023.100065","article-title":"Cognitive resilience and severe Alzheimer's disease neuropathology","volume":"3","author":"Ahangari","year":"2023","journal-title":"Aging Brain"},{"key":"2026090107113423500_DEV204910C4","doi-asserted-by":"publisher","first-page":"e41770","DOI":"10.7554\/eLife.41770","article-title":"The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders","volume":"8","author":"Ang","year":"2019","journal-title":"eLife"},{"key":"2026090107113423500_DEV204910C5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"2026090107113423500_DEV204910C6","doi-asserted-by":"publisher","first-page":"dev.125351","DOI":"10.1242\/dev.125351","article-title":"Retinal development anomalies and cone photoreceptors degeneration upon Bmi1 deficiency","volume":"143","author":"Barabino","year":"2016","journal-title":"Development"},{"key":"2026090107113423500_DEV204910C7","doi-asserted-by":"publisher","first-page":"eabd7695","DOI":"10.1126\/scitranslmed.abd7695","article-title":"MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration","volume":"13","author":"Barker","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"2026090107113423500_DEV204910C8","doi-asserted-by":"publisher","first-page":"11613","DOI":"10.1093\/nar\/gkad889","article-title":"DNA elements tether canonical Polycomb Repressive Complex 1 to human genes","volume":"51","author":"Barrasa","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2026090107113423500_DEV204910C9","doi-asserted-by":"publisher","first-page":"e1058232023","DOI":"10.1523\/JNEUROSCI.1058-23.2023","article-title":"The Mef2c gene dose-dependently controls hippocampal neurogenesis and the expression of autism-like behaviors","volume":"44","author":"Basu","year":"2024","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C124","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"2026090107113423500_DEV204910C10","doi-asserted-by":"publisher","first-page":"106152","DOI":"10.1016\/j.isci.2023.106152","article-title":"Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease","volume":"26","author":"Beckmann","year":"2023","journal-title":"iScience"},{"key":"2026090107113423500_DEV204910C11","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1002\/dvdy.22619","article-title":"Msx1 and Msx2 in limb mesenchyme modulate digit number and identity","volume":"240","author":"Bensoussan-Trigano","year":"2011","journal-title":"Dev. Dyn."},{"key":"2026090107113423500_DEV204910C12","doi-asserted-by":"publisher","first-page":"4947","DOI":"10.1038\/s41467-023-40611-4","article-title":"Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature","volume":"14","author":"Berson","year":"2023","journal-title":"Nat. Commun."},{"key":"2026090107113423500_DEV204910C13","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.gendis.2015.04.001","article-title":"Bmi-1: at the crossroads of physiological and pathological biology","volume":"2","author":"Bhattacharya","year":"2015","journal-title":"Genes Dis."},{"key":"2026090107113423500_DEV204910C14","doi-asserted-by":"publisher","first-page":"7627","DOI":"10.1523\/JNEUROSCI.22-17-07627.2002","article-title":"Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex","volume":"22","author":"Bishop","year":"2002","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C15","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/s41580-021-00398-y","article-title":"The molecular principles of gene regulation by Polycomb repressive complexes","volume":"22","author":"Blackledge","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026090107113423500_DEV204910C125","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.bbrc.2006.07.124","article-title":"SALL4 is directly activated by TCF\/LEF in the canonical Wnt signaling pathway","volume":"348","author":"B\u00f6hm","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026090107113423500_DEV204910C16","doi-asserted-by":"publisher","first-page":"dmm049854","DOI":"10.1242\/dmm.049854","article-title":"NR2F1 shapes mitochondria in the mouse brain, providing new insights into Bosch-Boonstra-Schaaf optic atrophy syndrome","volume":"16","author":"Bonzano","year":"2023","journal-title":"Dis. Model. Mech."},{"key":"2026090107113423500_DEV204910C17","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1038\/sj.emboj.7601144","article-title":"Structure and E3-ligase activity of the Ring\u2013Ring complex of Polycomb proteins Bmi1 and Ring1b","volume":"25","author":"Buchwald","year":"2006","journal-title":"EMBO J."},{"key":"2026090107113423500_DEV204910C18","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/s41586-023-06424-7","article-title":"Transient naive reprogramming corrects hiPS cells functionally and epigenetically","volume":"620","author":"Buckberry","year":"2023","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C19","doi-asserted-by":"publisher","first-page":"eaba5933","DOI":"10.1126\/sciadv.aba5933","article-title":"Dedifferentiation and neuronal repression define familial Alzheimer's disease","volume":"6","author":"Caldwell","year":"2020","journal-title":"Sci. Adv."},{"key":"2026090107113423500_DEV204910C20","doi-asserted-by":"publisher","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2026090107113423500_DEV204910C21","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1523\/JNEUROSCI.5303-08.2009","article-title":"The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity","volume":"29","author":"Chatoo","year":"2009","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1101\/gad.345363.120","article-title":"Polycomb complexes redundantly maintain epidermal stem cell identity during development","volume":"35","author":"Cohen","year":"2021","journal-title":"Genes Dev."},{"key":"2026090107113423500_DEV204910C23","doi-asserted-by":"publisher","first-page":"eabi8654","DOI":"10.1126\/science.abi8654","article-title":"Functional regulatory variants implicate distinct transcriptional networks in dementia","volume":"377","author":"Cooper","year":"2022","journal-title":"Science"},{"key":"2026090107113423500_DEV204910C24","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/s41598-018-37444-3","article-title":"Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+\/\u2212 mice","volume":"9","author":"El Hajjar","year":"2019","journal-title":"Sci. Rep."},{"key":"2026090107113423500_DEV204910C25","doi-asserted-by":"publisher","first-page":"eadl3188","DOI":"10.1126\/sciadv.adl3188","article-title":"The molecular basis of cell memory in mammals: the epigenetic cycle","volume":"10","author":"Espinosa-Mart\u00ednez","year":"2024","journal-title":"Sci. Adv."},{"key":"2026090107113423500_DEV204910C26","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.neuron.2012.12.011","article-title":"Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo","volume":"77","author":"Espuny-Camacho","year":"2013","journal-title":"Neuron"},{"key":"2026090107113423500_DEV204910C27","doi-asserted-by":"publisher","first-page":"e1005968","DOI":"10.1371\/journal.pcbi.1005968","article-title":"Reactome graph database: Efficient access to complex pathway data","volume":"14","author":"Fabregat","year":"2018","journal-title":"PLoS Comput. Biol."},{"key":"2026090107113423500_DEV204910C28","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1093\/hmg\/ddad142","article-title":"Genes positively regulated by Mef2c in cortical neurons are enriched for common genetic variation associated with IQ and educational attainment","volume":"32","author":"Fahey","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"2026090107113423500_DEV204910C29","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1038\/s41467-022-31627-3","article-title":"Mechanistic basis for maintenance of CHG DNA methylation in plants","volume":"13","author":"Fang","year":"2022","journal-title":"Nat. Commun."},{"key":"2026090107113423500_DEV204910C30","doi-asserted-by":"publisher","first-page":"2653","DOI":"10.1016\/j.celrep.2018.04.097","article-title":"Modeling late-onset sporadic Alzheimer's disease through BMI1 deficiency","volume":"23","author":"Flamier","year":"2018","journal-title":"Cell Rep."},{"key":"2026090107113423500_DEV204910C31","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.tins.2023.07.006","article-title":"Alzheimer's disease and related tauopathies: disorders of disrupted neuronal identity","volume":"46","author":"Frost","year":"2023","journal-title":"Trends Neurosci."},{"key":"2026090107113423500_DEV204910C32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nn.3639","article-title":"Tau promotes neurodegeneration through global chromatin relaxation","volume":"17","author":"Frost","year":"2014","journal-title":"Nat. Neurosci."},{"key":"2026090107113423500_DEV204910C33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cub.2015.11.039","article-title":"Lamin dysfunction mediates neurodegeneration in tauopathies","volume":"26","author":"Frost","year":"2016","journal-title":"Curr. Biol."},{"key":"2026090107113423500_DEV204910C34","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1038\/nn1093","article-title":"Emx2 patterns the neocortex by regulating FGF positional signaling","volume":"6","author":"Fukuchi-Shimogori","year":"2003","journal-title":"Nat. Neurosci."},{"key":"2026090107113423500_DEV204910C35","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/s41421-022-00407-0","article-title":"Cell fate determining molecular switches and signaling pathways in Pax7-expressing somitic mesoderm","volume":"8","author":"Fung","year":"2022","journal-title":"Cell Discov."},{"key":"2026090107113423500_DEV204910C36","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1016\/j.cell.2024.02.025","article-title":"Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes","volume":"187","author":"Ganz","year":"2024","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C37","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1074\/mcp.TIR120.002155","article-title":"ReactomeGSA - efficient multi-omics comparative pathway analysis","volume":"19","author":"Griss","year":"2020","journal-title":"Mol. Cell. Proteomics"},{"key":"2026090107113423500_DEV204910C38","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C39","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1046\/j.1440-169X.1997.t01-5-00006.x","article-title":"Msx1 expressing mesoderm is important for the apical ectodermal ridge (AER)-signal transfer in chick limb development","volume":"39","author":"Hara","year":"1997","journal-title":"Dev. Growth Differ."},{"key":"2026090107113423500_DEV204910C40","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1146\/annurev-genom-090413-025437","article-title":"Non-CG methylation in the human genome","volume":"16","author":"He","year":"2015","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"2026090107113423500_DEV204910C41","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"2026090107113423500_DEV204910C42","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/j.stem.2022.11.010","article-title":"Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease","volume":"29","author":"Herdy","year":"2022","journal-title":"Cell Stem Cell"},{"key":"2026090107113423500_DEV204910C43","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10821","article-title":"Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells","volume":"482","author":"Israel","year":"2012","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/16476","article-title":"The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus","volume":"397","author":"Jacobs","year":"1999","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C45","doi-asserted-by":"publisher","first-page":"D498","DOI":"10.1093\/nar\/gkz1031","article-title":"The reactome pathway knowledgebase","volume":"48","author":"Jassal","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2026090107113423500_DEV204910C46","doi-asserted-by":"publisher","first-page":"154268","DOI":"10.1016\/j.prp.2022.154268","article-title":"ZIC5 promotes aggressiveness and cancer stemness in cervical squamous cell carcinoma","volume":"241","author":"Jia","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"2026090107113423500_DEV204910C47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"2026090107113423500_DEV204910C48","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and A\u03b2 in Alzheimer's Disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"key":"2026090107113423500_DEV204910C49","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1091\/mbc.e08-02-0187","article-title":"R-spondin family members regulate the Wnt pathway by a common mechanism","volume":"19","author":"Kim","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"2026090107113423500_DEV204910C50","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature09342","article-title":"Epigenetic memory in induced pluripotent stem cells","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C51","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s13195-021-00906-4","article-title":"BMI1 is associated with CSF amyloid-\u03b2 and rates of cognitive decline in Alzheimer's disease","volume":"13","author":"Kim","year":"2021","journal-title":"Alzheimers Res. Ther."},{"key":"2026090107113423500_DEV204910C52","doi-asserted-by":"publisher","first-page":"5097","DOI":"10.1523\/JNEUROSCI.0239-05.2005","article-title":"Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium","volume":"25","author":"Kimura","year":"2005","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C53","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primer"},{"key":"2026090107113423500_DEV204910C54","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.stem.2013.01.009","article-title":"Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular A\u03b2 and differential drug responsiveness","volume":"12","author":"Kondo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2026090107113423500_DEV204910C55","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3390\/cells12081204","article-title":"The multifaceted role of WNT signaling in Alzheimer's disease onset and age-related progression","volume":"12","author":"Kostes","year":"2023","journal-title":"Cells"},{"key":"2026090107113423500_DEV204910C56","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","article-title":"Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications","volume":"27","author":"Krueger","year":"2011","journal-title":"Bioinformatics"},{"key":"2026090107113423500_DEV204910C57","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1038\/s41467-022-32295-z","article-title":"PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression","volume":"13","author":"Lan","year":"2022","journal-title":"Nat. Commun."},{"key":"2026090107113423500_DEV204910C58","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C59","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3233\/JAD-221184","article-title":"Regulation of USP25 by SP1 associates with amyloidogenesis","volume":"92","author":"Li","year":"2023","journal-title":"J. Alzheimers Dis."},{"key":"2026090107113423500_DEV204910C60","doi-asserted-by":"publisher","first-page":"1383200","DOI":"10.3389\/fcell.2024.1383200","article-title":"Research advances of polycomb group proteins in regulating mammalian development","volume":"12","author":"Li","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"2026090107113423500_DEV204910C61","doi-asserted-by":"publisher","first-page":"113118","DOI":"10.1016\/j.yexcr.2022.113118","article-title":"ZIC2 promotes colorectal cancer growth and metastasis through the TGF-\u03b2 signaling pathway","volume":"415","author":"Liu","year":"2022","journal-title":"Exp. Cell Res."},{"key":"2026090107113423500_DEV204910C62","doi-asserted-by":"publisher","first-page":"4980","DOI":"10.1016\/j.cell.2025.06.031","article-title":"Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C63","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/epigenomes6030023","article-title":"The role of polycomb proteins in cell lineage commitment and embryonic development","volume":"6","author":"Loh","year":"2022","journal-title":"Epigenomes"},{"key":"2026090107113423500_DEV204910C64","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2026090107113423500_DEV204910C65","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1038\/s43587-023-00527-6","article-title":"The information theory of aging","volume":"3","author":"Lu","year":"2023","journal-title":"Nat. Aging"},{"key":"2026090107113423500_DEV204910C66","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nature14274","article-title":"Early reprogramming regulators identified by prospective isolation and mass cytometry","volume":"521","author":"Lujan","year":"2015","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C67","doi-asserted-by":"publisher","first-page":"12780","DOI":"10.1523\/JNEUROSCI.0534-12.2012","article-title":"Members of the myocyte enhancer factor 2 transcription factor family differentially regulate Bdnf transcription in response to neuronal depolarization","volume":"32","author":"Lyons","year":"2012","journal-title":"J. Neurosci."},{"key":"2026090107113423500_DEV204910C68","doi-asserted-by":"publisher","first-page":"e3000153","DOI":"10.1371\/journal.pbio.3000153","article-title":"Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm","volume":"17","author":"Magli","year":"2019","journal-title":"PLoS Biol."},{"key":"2026090107113423500_DEV204910C69","doi-asserted-by":"publisher","first-page":"4365","DOI":"10.1016\/j.cell.2023.08.039","article-title":"Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology","volume":"186","author":"Mathys","year":"2023","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C70","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.cell.2014.09.055","article-title":"Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation","volume":"159","author":"Matoba","year":"2014","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C71","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.tig.2022.03.010","article-title":"DNA methylation: a historical perspective","volume":"38","author":"Mattei","year":"2022","journal-title":"Trends Genet."},{"key":"2026090107113423500_DEV204910C73","doi-asserted-by":"publisher","first-page":"e51740","DOI":"10.15252\/embr.202051740","article-title":"Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling","volume":"22","author":"Mediani","year":"2021","journal-title":"EMBO Rep."},{"key":"2026090107113423500_DEV204910C74","doi-asserted-by":"publisher","first-page":"12990","DOI":"10.3390\/ijms232112990","article-title":"Microglia and Alzheimer's disease","volume":"23","author":"Merighi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026090107113423500_DEV204910C75","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/j.stem.2021.04.004","article-title":"Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients","volume":"28","author":"Mertens","year":"2021","journal-title":"Cell Stem Cell"},{"key":"2026090107113423500_DEV204910C76","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neurobiolaging.2021.07.010","article-title":"Absence of coding somatic single nucleotide variants within well-known candidate genes in late-onset sporadic Alzheimer's Disease based on the analysis of multi-omics data","volume":"108","author":"Min","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"2026090107113423500_DEV204910C77","doi-asserted-by":"publisher","first-page":"eaaz8797","DOI":"10.1126\/sciadv.aaz8797","article-title":"A Zic2-regulated switch in a noncanonical Wnt\/\u03b2catenin pathway is essential for the formation of bilateral circuits","volume":"6","author":"Morenilla-Palao","year":"2020","journal-title":"Sci. Adv."},{"key":"2026090107113423500_DEV204910C78","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nrn786","article-title":"Neural induction, the default model and embryonic stem cells","volume":"3","author":"Mu\u00f1oz-Sanju\u00e1n","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090107113423500_DEV204910C79","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Health"},{"key":"2026090107113423500_DEV204910C80","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3390\/ijms24010283","article-title":"The difference in zinc concentrations required for induction among metallothionein isoforms can be explained by the different MTF1 affinities to MREs in its promoter","volume":"24","author":"Ogushi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026090107113423500_DEV204910C81","doi-asserted-by":"publisher","first-page":"20140367","DOI":"10.1098\/rstb.2014.0367","article-title":"Present and future challenges of induced pluripotent stem cells","volume":"370","author":"Ohnuki","year":"2015","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"2026090107113423500_DEV204910C82","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nmeth.1591","article-title":"A more efficient method to generate integration-free human iPS cells","volume":"8","author":"Okita","year":"2011","journal-title":"Nat. Methods"},{"key":"2026090107113423500_DEV204910C83","doi-asserted-by":"publisher","first-page":"107887","DOI":"10.1016\/j.isci.2023.107887","article-title":"Acquisition of neural fate by combination of BMP blockade and chromatin modification","volume":"26","author":"Ong","year":"2023","journal-title":"iScience"},{"key":"2026090107113423500_DEV204910C84","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41580-022-00483-w","article-title":"Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance","volume":"23","author":"Padeken","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026090107113423500_DEV204910C85","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/14786440109462720","article-title":"LIII. On lines and planes of closest fit to systems of points in space","volume":"2","author":"Pearson","year":"1901","journal-title":"Lond. Edinb. Dublin Philos. Mag. J. Sci."},{"key":"2026090107113423500_DEV204910C86","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1038\/s41467-025-56569-4","article-title":"iPSCs and iPSC-derived cells as a model of human genetic and epigenetic variation","volume":"16","author":"Quaid","year":"2025","journal-title":"Nat. Commun."},{"key":"2026090107113423500_DEV204910C87","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3724\/abbs.2021012","article-title":"MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer's disease in vivo and in vitro","volume":"54","author":"Ren","year":"2022","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"2026090107113423500_DEV204910C88","doi-asserted-by":"publisher","first-page":"1222265","DOI":"10.3389\/fcimb.2023.1222265","article-title":"JunB: a paradigm for Jun family in immune response and cancer","volume":"13","author":"Ren","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2026090107113423500_DEV204910C89","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1016\/j.devcel.2022.05.006","article-title":"\u03b3-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor","volume":"57","author":"Restrepo","year":"2022","journal-title":"Dev. Cell"},{"key":"2026090107113423500_DEV204910C90","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"2026090107113423500_DEV204910C91","doi-asserted-by":"publisher","first-page":"e36483","DOI":"10.1371\/journal.pone.0036483","article-title":"Localizing transcriptional regulatory elements at the mouse Dlk1 locus","volume":"7","author":"Rogers","year":"2012","journal-title":"PLoS ONE"},{"key":"2026090107113423500_DEV204910C92","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/pace.12537","article-title":"Incidence of dementia in relation to genetic variants at PITX2, ZFHX3, and ApoE \u03b54 in atrial fibrillation patients","volume":"38","author":"Rollo","year":"2015","journal-title":"Pacing Clin. Electrophysiol."},{"key":"2026090107113423500_DEV204910C93","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1056\/NEJMoa0806142","article-title":"Age, neuropathology, and dementia","volume":"360","author":"Savva","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2026090107113423500_DEV204910C94","doi-asserted-by":"publisher","first-page":"e202311021","DOI":"10.1083\/jcb.202311021","article-title":"Crosstalk within and beyond the Polycomb repressive system","volume":"223","author":"Shi","year":"2024","journal-title":"J. Cell Biol."},{"key":"2026090107113423500_DEV204910C95","doi-asserted-by":"publisher","first-page":"8703","DOI":"10.1073\/pnas.0602569103","article-title":"Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging","volume":"103","author":"Shumaker","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107113423500_DEV204910C96","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13045-018-0645-x","article-title":"The roles of metallothioneins in carcinogenesis","volume":"11","author":"Si","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"2026090107113423500_DEV204910C97","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s13148-021-01158-7","article-title":"Cellular reprogramming and epigenetic rejuvenation","volume":"13","author":"Simpson","year":"2021","journal-title":"Clin. Epigenet."},{"key":"2026090107113423500_DEV204910C98","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nrc1991","article-title":"Polycomb silencers control cell fate, development and cancer","volume":"6","author":"Sparmann","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"2026090107113423500_DEV204910C99","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C100","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107113423500_DEV204910C101","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C102","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.cell.2022.12.047","article-title":"Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice","volume":"186","author":"Takahashi","year":"2023","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C103","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.cell.2014.08.029","article-title":"Resetting transcription factor control circuitry toward ground-state pluripotency in human","volume":"158","author":"Takashima","year":"2014","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C104","doi-asserted-by":"publisher","first-page":"iyad031","DOI":"10.1093\/genetics\/iyad031","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"The Gene Ontology Consortium","year":"2023","journal-title":"Genetics"},{"key":"2026090107113423500_DEV204910C105","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","article-title":"Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration","volume":"14","author":"Thorvaldsdottir","year":"2013","journal-title":"Brief. Bioinform."},{"key":"2026090107113423500_DEV204910C106","doi-asserted-by":"publisher","first-page":"111178","DOI":"10.1016\/j.exger.2020.111178","article-title":"Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer's disease","volume":"144","author":"Tzekaki","year":"2021","journal-title":"Exp. Gerontol."},{"key":"2026090107113423500_DEV204910C107","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS\u2013IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat. Neurosci."},{"key":"2026090107113423500_DEV204910C108","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1101\/gad.8.7.757","article-title":"Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene","volume":"8","author":"van der Lugt","year":"1994","journal-title":"Genes Dev."},{"key":"2026090107113423500_DEV204910C109","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1093\/hmg\/ddv180","article-title":"Kabuki syndrome genes KMT2D and KDM6A : functional analyses demonstrate critical roles in craniofacial, heart and brain development","volume":"24","author":"van Laarhoven","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"2026090107113423500_DEV204910C110","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S1474-4422(13)70044-9","article-title":"Amyloid \u03b2 deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study","volume":"12","author":"Villemagne","year":"2013","journal-title":"Lancet Neurol."},{"key":"2026090107113423500_DEV204910C111","doi-asserted-by":"publisher","first-page":"6070","DOI":"10.7150\/jca.44367","article-title":"ZIC2 promotes cancer stem cell traits via up-regulating OCT4 expression in lung adenocarcinoma cells","volume":"11","author":"Wei-Hua","year":"2020","journal-title":"J. Cancer"},{"key":"2026090107113423500_DEV204910C112","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1242\/dev.120.4.785","article-title":"Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification","volume":"120","author":"Williams","year":"1994","journal-title":"Development"},{"key":"2026090107113423500_DEV204910C113","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1016\/j.cell.2023.08.040","article-title":"Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion","volume":"186","author":"Xiong","year":"2023","journal-title":"Cell"},{"key":"2026090107113423500_DEV204910C114","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/stem.3168","article-title":"Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors","volume":"38","author":"Xu","year":"2020","journal-title":"Stem Cells"},{"key":"2026090107113423500_DEV204910C115","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41419-021-03863-w","article-title":"Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of \u03b2-catenin","volume":"12","author":"Xu","year":"2021","journal-title":"Cell Death Dis."},{"key":"2026090107113423500_DEV204910C116","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12964-019-0501-9","article-title":"Presenilin1 exerts antiproliferative effects by repressing the Wnt\/\u03b2-catenin pathway in glioblastoma","volume":"18","author":"Yang","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"2026090107113423500_DEV204910C117","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nature06968","article-title":"The ground state of embryonic stem cell self-renewal","volume":"453","author":"Ying","year":"2008","journal-title":"Nature"},{"key":"2026090107113423500_DEV204910C118","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.stem.2023.04.016","article-title":"The single-cell and spatial transcriptional landscape of human gastrulation and early brain development","volume":"30","author":"Zeng","year":"2023","journal-title":"Cell Stem Cell"},{"key":"2026090107113423500_DEV204910C119","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1038\/s41598-023-34021-1","article-title":"Identification of oxidative stress-related genes differentially expressed in Alzheimer's disease and construction of a hub gene-based diagnostic model","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci. Rep."},{"key":"2026090107113423500_DEV204910C120","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.stem.2010.04.017","article-title":"Pax6 is a human neuroectoderm cell fate determinant","volume":"7","author":"Zhang","year":"2010","journal-title":"Cell Stem Cell"},{"key":"2026090107113423500_DEV204910C121","doi-asserted-by":"publisher","first-page":"107521","DOI":"10.1016\/j.celrep.2020.03.085","article-title":"Imbalance of excitatory\/inhibitory neuron differentiation in neurodevelopmental disorders with an NR2F1 point mutation","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Rep."},{"key":"2026090107113423500_DEV204910C122","doi-asserted-by":"publisher","first-page":"e151591","DOI":"10.1172\/JCI151591","article-title":"FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway","volume":"132","author":"Zhang","year":"2022","journal-title":"J. Clin. Invest."},{"key":"2026090107113423500_DEV204910C123","doi-asserted-by":"publisher","first-page":"14049","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204910\/3674876\/dev204910.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204910\/3679534\/dev204910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204910\/3679534\/dev204910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:11:42Z","timestamp":1788261102000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/1\/dev204910\/370294\/Epigenomic-alterations-and-neural-development"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":124,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.204910","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"dev204910"}}