{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:12:47Z","timestamp":1788264767649,"version":"build-2803163510"},"reference-count":83,"publisher":"The Company of Biologists","issue":"4","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"crossref","award":["PID2019-107340GB-I00"],"award-info":[{"award-number":["PID2019-107340GB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"crossref","award":["2021SGR00293"],"award-info":[{"award-number":["2021SGR00293"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"European Research Council","award":["ERCAdG 787470"],"award-info":[{"award-number":["ERCAdG 787470"]}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"crossref","award":["EPSRC-ERC EP\/Y03298\/1"],"award-info":[{"award-number":["EPSRC-ERC EP\/Y03298\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["FC001317"],"award-info":[{"award-number":["FC001317"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"crossref","award":["FC001175"],"award-info":[{"award-number":["FC001175"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["FC001317"],"award-info":[{"award-number":["FC001317"]}]},{"name":"Medical Research Council","award":["FC001175"],"award-info":[{"award-number":["FC001175"]}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["FC001317"],"award-info":[{"award-number":["FC001317"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["FC001175"],"award-info":[{"award-number":["FC001175"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005774","name":"Universitat de Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The plasticity of intact adult neural tissue in the vicinity of neural damage helps restore circuit function. Much remains to be learned about the mechanisms regulating this process and the reported sex differences in recovery outcomes. Here, we present the fly gut and its innervation as a simplified model to address these questions. We show that ingestion of damaging agents triggers a reversible increase in adult enteric neural tissue in females, consistent with growth rather than neurogenesis. This growth can be influenced by gut-derived reactive oxygen species, as suggested by suppression with an antioxidant. Interestingly, males do not display neural plasticity, and masculinization of neurons in females suppresses damage-dependent neural growth. Conversely, feminizing male neurons does not confer plasticity, suggesting that sex-specific cues from surrounding tissues may be required for this response. Blocking plasticity reduces the dextran sulfate sodium-induced increase in defecation and further shortens survival, indicating that female-specific neural plasticity supports both gut function and viability. Together, these findings establish a physiological model to dissect cellular, molecular and sex-dependent regulators of adult neural plasticity relevant to circuit repair.<\/jats:p>","DOI":"10.1242\/dev.204945","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:29:45Z","timestamp":1769678985000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-dependent plasticity of adult neural tissue in response to damage"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-232X","authenticated-orcid":false,"given":"Marina","family":"Recatal\u00e0-Martinez","sequence":"first","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Gen\u00e8tica, Microbiologia i Estad\u00edstica, Facultat de Biologia , , Barcelona 08028,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5870-6346","authenticated-orcid":false,"given":"Manel","family":"Bosch","sequence":"additional","affiliation":[{"name":"Centres Cient\u00edfics i Tecnol\u00f2gics de la Universitat de Barcelona (CCiTUB) 2 Unitat de Microsc\u00f2pia \u00d2ptica Avan\u00e7ada , , Barcelona 08028,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-4169","authenticated-orcid":false,"given":"Pedro","family":"Gaspar","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute 3 , London NW1 1AT,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-1313","authenticated-orcid":false,"given":"Alessandro","family":"Mineo","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute 3 , London NW1 1AT,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2492-9247","authenticated-orcid":false,"given":"Santiago","family":"Rios","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Gen\u00e8tica, Microbiologia i Estad\u00edstica, Facultat de Biologia , , Barcelona 08028,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1082-5108","authenticated-orcid":false,"given":"Irene","family":"Miguel-Aliaga","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute 3 , London NW1 1AT,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-1983","authenticated-orcid":false,"given":"Marta","family":"Morey","sequence":"additional","affiliation":[{"name":"Universitat de Barcelona 1 Departament de Gen\u00e8tica, Microbiologia i Estad\u00edstica, Facultat de Biologia , , Barcelona 08028,","place":["Spain"]},{"name":"Institut de Biomedicina de la Universitat de Barcelona (IBUB) 4 Human Genetics and Disease , , Barcelona 08028,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"2026090107131147700_DEV204945C1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2008.10.016","article-title":"Tissue damage-induced intestinal stem cell division in Drosophila","volume":"4","author":"Amcheslavsky","year":"2009","journal-title":"Cell Stem Cell"},{"key":"2026090107131147700_DEV204945C82","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.conb.2019.12.004","article-title":"Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation","volume":"62","author":"Ameku","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"2026090107131147700_DEV204945C2","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.15252\/embj.201591517","article-title":"Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8\u2013Escargot switch","volume":"34","author":"Antonello","year":"2015","journal-title":"EMBO J."},{"key":"2026090107131147700_DEV204945C3","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/0092-8674(88)90248-6","article-title":"Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins","volume":"55","author":"Bell","year":"1988","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0092-8674(91)90157-T","article-title":"Positive autoregulation of Sex-lethal by alternative splicing maintains the female determined state in Drosophila","volume":"65","author":"Bell","year":"1991","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C5","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/dvg.1020100304","article-title":"Molecular genetics of transformer, a genetic switch controlling sexual differentiation in Drosophila","volume":"10","author":"Belote","year":"1989","journal-title":"Dev. Genet."},{"key":"2026090107131147700_DEV204945C6","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1002\/cne.902010404","article-title":"Embryonic and postembryonic morphogenesis of a grasshopper interneuron","volume":"201","author":"Bentley","year":"1981","journal-title":"J. Comp. Neurol."},{"key":"2026090107131147700_DEV204945C7","first-page":"1251","article-title":"Dynamic thresholding of gray level image","volume":"86","author":"Bernsen","year":"1986","journal-title":"Proc. Int. Conf. Pattern Recognit. Berl. ICPR"},{"key":"2026090107131147700_DEV204945C8","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/0092-8674(87)90332-1","article-title":"Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene","volume":"50","author":"Boggs","year":"1987","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C9","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0022-1910(00)00078-0","article-title":"Directional sensitivity of an identified wind-sensitive interneuron during the postembryonic development of the locust","volume":"46","author":"Bucher","year":"2000","journal-title":"J. Insect Physiol."},{"key":"2026090107131147700_DEV204945C10","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1101\/gad.1827009","article-title":"Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila","volume":"23","author":"Buchon","year":"2009","journal-title":"Genes Dev."},{"key":"2026090107131147700_DEV204945C11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.chom.2009.01.003","article-title":"Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation","volume":"5","author":"Buchon","year":"2009","journal-title":"Cell Host Microbe"},{"key":"2026090107131147700_DEV204945C12","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1741-7007-8-152","article-title":"DrosophilaEGFR pathway coordinates stem cell proliferation and gut remodeling following infection","volume":"8","author":"Buchon","year":"2010","journal-title":"BMC Biol."},{"key":"2026090107131147700_DEV204945C13","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.celrep.2013.04.001","article-title":"Morphological and molecular characterization of adult midgut compartmentalization in Drosophila","volume":"3","author":"Buchon","year":"2013","journal-title":"Cell Rep."},{"key":"2026090107131147700_DEV204945C14","doi-asserted-by":"publisher","first-page":"e1006346","DOI":"10.1371\/journal.pgen.1006346","article-title":"Allatostatin A signalling in Drosophila regulates feeding and sleep and is modulated by PDF","volume":"12","author":"Chen","year":"2016","journal-title":"PLoS Genet."},{"key":"2026090107131147700_DEV204945C15","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0271678X19882788","article-title":"Post-stroke remodeling processes in animal models and humans","volume":"40","author":"Cirillo","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"2026090107131147700_DEV204945C16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.cmet.2010.12.010","article-title":"Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis","volume":"13","author":"Cognigni","year":"2011","journal-title":"Cell Metab."},{"key":"2026090107131147700_DEV204945C17","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.02.610892","article-title":"A gut-brain-gut interoceptive circuit loop gates sugar ingestion in Drosophila","author":"Cui","year":"2024","journal-title":"bioRxiv"},{"key":"2026090107131147700_DEV204945C18","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1007\/s12264-022-00959-x","article-title":"Restoring after central nervous system injuries: neural mechanisms and translational applications of motor recovery","volume":"38","author":"Gao","year":"2022","journal-title":"Neurosci. Bull."},{"key":"2026090107131147700_DEV204945C83","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41586-020-2866-8","article-title":"Enteric neurons increase maternal food intake during reproduction","volume":"587","author":"Hadjieconomou","year":"2020","journal-title":"Nature"},{"key":"2026090107131147700_DEV204945C19","doi-asserted-by":"publisher","first-page":"6925","DOI":"10.1038\/s41467-024-51228-6","article-title":"Cellular sex throughout the organism underlies somatic sexual differentiation","volume":"15","author":"H\u00e9rault","year":"2024","journal-title":"Nat. Commun."},{"key":"2026090107131147700_DEV204945C20","first-page":"65","article-title":"A simple sequentially rejective multiple test procedure","volume":"6","author":"Holm","year":"1979","journal-title":"Scand. J. Stat."},{"key":"2026090107131147700_DEV204945C84","doi-asserted-by":"publisher","DOI":"10.17912\/micropub.biology.000628","article-title":"Enteroendocrine cell expression of split-GAL4 drivers bearing regulatory sequences associated with panneuronally expressed genes in Drosophila melanogaster","author":"Holsopple","year":"2022","journal-title":"MicroPubl. Biol."},{"key":"2026090107131147700_DEV204945C22","doi-asserted-by":"publisher","first-page":"jcs226860","DOI":"10.1242\/jcs.226860","article-title":"DSS-induced damage to basement membranes is repaired by matrix replacement and crosslinking","volume":"132","author":"Howard","year":"2019","journal-title":"J. Cell Sci."},{"key":"2026090107131147700_DEV204945C23","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fnmol.2018.00266","article-title":"Sex differences in synaptic plasticity: hormones and beyond","volume":"11","author":"Hyer","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"2026090107131147700_DEV204945C24","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/344461a0","article-title":"Binding of the Drosophila Sex-lethal gene product to the alternative splice site of transformer primary transcript","volume":"344","author":"Inoue","year":"1990","journal-title":"Nature"},{"key":"2026090107131147700_DEV204945C25","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","article-title":"A GAL4-Driver Line Resource for Drosophila Neurobiology","volume":"2","author":"Jenett","year":"2012","journal-title":"Cell Rep."},{"key":"2026090107131147700_DEV204945C26","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1016\/j.cell.2009.05.014","article-title":"Cytokine\/Jak\/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut","volume":"137","author":"Jiang","year":"2009","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C27","doi-asserted-by":"publisher","first-page":"3337","DOI":"10.1007\/s00018-016-2235-9","article-title":"Intestinal stem cell response to injury: lessons from Drosophila","volume":"73","author":"Jiang","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"2026090107131147700_DEV204945C28","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. Assoc."},{"key":"2026090107131147700_DEV204945C29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0734-189X(85)90125-2","article-title":"A new method for gray-level picture thresholding using the entropy of the histogram","volume":"29","author":"Kapur","year":"1985","journal-title":"Comput. Vis. Graph. Image Process."},{"key":"2026090107131147700_DEV204945C30","doi-asserted-by":"publisher","first-page":"jeb.122960","DOI":"10.1242\/jeb.122960","article-title":"A subset of neurons controls the permeability of the peritrophic matrix and midgut structure in Drosophila adults","volume":"30","author":"Kenmoku","year":"2016","journal-title":"J. Exp. Biol."},{"key":"2026090107131147700_DEV204945C31","doi-asserted-by":"publisher","first-page":"5951","DOI":"10.1038\/s41598-024-56453-z","article-title":"Investigating female versus male differences in white matter neuroplasticity associated with complex visuo-motor learning","volume":"14","author":"Kirby","year":"2024","journal-title":"Sci. Rep."},{"key":"2026090107131147700_DEV204945C32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/307175","article-title":"Neural plasticity in multiple sclerosis: the functional and molecular background","volume":"2015","author":"Ksiazek-Winiarek","year":"2015","journal-title":"Neural Plast."},{"key":"2026090107131147700_DEV204945C33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ibmb.2015.07.003","article-title":"From mouth to anus: functional and structural relevance of enteric neurons in the Drosophila melanogaster gut","volume":"67","author":"Kuraishi","year":"2015","journal-title":"Insect Biochem. Mol. Biol."},{"key":"2026090107131147700_DEV204945C34","doi-asserted-by":"publisher","first-page":"12931","DOI":"10.1073\/pnas.0705469104","article-title":"General design principle for scalable neural circuits in a vertebrate retina","volume":"104","author":"Lee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107131147700_DEV204945C35","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1146\/annurev-genet-111212-133343","article-title":"The digestive tract of Drosophila melanogaster","volume":"47","author":"Lemaitre","year":"2013","journal-title":"Annu. Rev. Genet."},{"key":"2026090107131147700_DEV204945C36","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/0031-3203(93)90115-D","article-title":"Minimum cross entropy thresholding","volume":"26","author":"Li","year":"1993","journal-title":"Pattern Recognit."},{"key":"2026090107131147700_DEV204945C37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jmcb\/mjp028","article-title":"Paracrine unpaired signaling through the JAK\/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells","volume":"2","author":"Lin","year":"2010","journal-title":"J. Mol. Cell Biol."},{"key":"2026090107131147700_DEV204945C38","doi-asserted-by":"publisher","first-page":"114109","DOI":"10.1016\/j.celrep.2024.114109","article-title":"Duox activation in Drosophila Malpighian tubules stimulates intestinal epithelial renewal through a countercurrent flow","volume":"43","author":"Liu","year":"2024","journal-title":"Cell Rep."},{"key":"2026090107131147700_DEV204945C39","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.3390\/ijms21082718","article-title":"mTOR signaling at the crossroad between metazoan regeneration and human diseases","volume":"21","author":"Lund-Ricard","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026090107131147700_DEV204945C40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.neuro.28.061604.135632","article-title":"Axon retraction and degeneration in development and disease","volume":"28","author":"Luo","year":"2005","journal-title":"Annu. Rev. Neurosci."},{"key":"2026090107131147700_DEV204945C41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s41583-018-0001-8","article-title":"Intrinsic mechanisms of neuronal axon regeneration","volume":"19","author":"Mahar","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090107131147700_DEV204945C42","doi-asserted-by":"publisher","first-page":"RP99999","DOI":"10.7554\/eLife.99999","article-title":"Glia-mediated gut\u2013brain cytokine signaling couples sleep to intestinal inflammatory responses induced by oxidative stress","volume":"13","author":"Malita","year":"2025","journal-title":"eLife"},{"key":"2026090107131147700_DEV204945C43","doi-asserted-by":"publisher","first-page":"e00886","DOI":"10.7554\/eLife.00886","article-title":"Physiological and stem cell compartmentalization within the Drosophila midgut","volume":"2","author":"Marianes","year":"2013","journal-title":"eLife"},{"key":"2026090107131147700_DEV204945C44","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1126\/science.1089035","article-title":"Spatiotemporal rescue of memory dysfunction in Drosophila","volume":"302","author":"McGuire","year":"2003","journal-title":"Science"},{"key":"2026090107131147700_DEV204945C45","doi-asserted-by":"publisher","first-page":"dmm049332","DOI":"10.1242\/dmm.049332","article-title":"Investigating local and systemic intestinal signalling in health and disease with Drosophila","volume":"15","author":"Medina","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"2026090107131147700_DEV204945C46","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1016\/j.devcel.2025.06.036","article-title":"Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila","volume":"60","author":"Medina","year":"2025","journal-title":"Dev. Cell"},{"key":"2026090107131147700_DEV204945C47","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/wdev.108","article-title":"Development and plasticity of the Drosophila larval neuromuscular junction","volume":"2","author":"Menon","year":"2013","journal-title":"WIREs Dev. Biol."},{"key":"2026090107131147700_DEV204945C48","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1534\/genetics.118.300224","article-title":"Anatomy and physiology of the digestive tract of Drosophila melanogaster","volume":"210","author":"Miguel-Aliaga","year":"2018","journal-title":"Genetics"},{"key":"2026090107131147700_DEV204945C49","doi-asserted-by":"publisher","first-page":"e63049","DOI":"10.7554\/eLife.63049","article-title":"Control of feeding by Piezo-mediated gut mechanosensation in Drosophila","volume":"10","author":"Min","year":"2021","journal-title":"eLife"},{"key":"2026090107131147700_DEV204945C50","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrn2735","article-title":"Plasticity during stroke recovery: from synapse to behaviour","volume":"10","author":"Murphy","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090107131147700_DEV204945C51","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1016\/S1047-9651(02)00054-2","article-title":"Functional and structural plasticity in motor cortex: implications for stroke recovery","volume":"14","author":"Nudo","year":"2003","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"2026090107131147700_DEV204945C52","doi-asserted-by":"publisher","first-page":"e04402","DOI":"10.7554\/eLife.04402","article-title":"Regulation of food intake by mechanosensory ion channels in enteric neurons","volume":"3","author":"Olds","year":"2014","journal-title":"eLife"},{"key":"2026090107131147700_DEV204945C53","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1093\/bioinformatics\/btt276","article-title":"TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization","volume":"29","author":"Ollion","year":"2013","journal-title":"Bioinformatics"},{"key":"2026090107131147700_DEV204945C54","doi-asserted-by":"publisher","first-page":"5944","DOI":"10.1242\/jcs.113100","article-title":"Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division","volume":"125","author":"Osman","year":"2012","journal-title":"J. Cell Sci."},{"key":"2026090107131147700_DEV204945C55","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/1873-3468.12972","article-title":"Regulation of neuronal development and function by ROS","volume":"592","author":"Oswald","year":"2018","journal-title":"FEBS Lett."},{"key":"2026090107131147700_DEV204945C56","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41556-021-00676-z","article-title":"Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila","volume":"23","author":"Perochon","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"2026090107131147700_DEV204945C57","doi-asserted-by":"publisher","first-page":"792643","DOI":"10.3389\/fneur.2021.792643","article-title":"Restoring function after severe spinal cord injury through BioLuminescent-OptoGenetics","volume":"12","author":"Petersen","year":"2022","journal-title":"Front. Neurol."},{"key":"2026090107131147700_DEV204945C58","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s41586-023-06627-y","article-title":"Cholinergic neurons trigger epithelial Ca2+ currents to heal the gut","volume":"623","author":"Petsakou","year":"2023","journal-title":"Nature"},{"key":"2026090107131147700_DEV204945C59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/481574","article-title":"Functional and structural brain plasticity enhanced by motor and cognitive rehabilitation in multiple sclerosis","volume":"2015","author":"Prosperini","year":"2015","journal-title":"Neural Plast."},{"key":"2026090107131147700_DEV204945C60","doi-asserted-by":"publisher","first-page":"21528","DOI":"10.1073\/pnas.1215849110","article-title":"Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila","volume":"109","author":"Rera","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107131147700_DEV204945C61","doi-asserted-by":"publisher","first-page":"dev202384","DOI":"10.1242\/dev.202384","article-title":"Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the Drosophila leg","volume":"151","author":"Rodr\u00edguez","year":"2024","journal-title":"Development"},{"key":"2026090107131147700_DEV204945C62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-neuro-080317-062015","article-title":"Structural plasticity in adulthood with motor learning and stroke rehabilitation","volume":"41","author":"Sampaio-Baptista","year":"2018","journal-title":"Annu. Rev. Neurosci."},{"key":"2026090107131147700_DEV204945C63","doi-asserted-by":"publisher","first-page":"e1010526","DOI":"10.1371\/journal.pgen.1010526","article-title":"TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis","volume":"19","author":"Sanal","year":"2023","journal-title":"PLoS Genet."},{"key":"2026090107131147700_DEV204945C64","doi-asserted-by":"publisher","first-page":"e1005595","DOI":"10.1371\/journal.pgen.1005595","article-title":"ROS-induced JNK and p38 signaling is required for unpaired cytokine activation during Drosophila regeneration","volume":"11","author":"Santab\u00e1rbara-Ruiz","year":"2015","journal-title":"PLoS Genet."},{"key":"2026090107131147700_DEV204945C65","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1361-8415(98)80009-1","article-title":"Three-dimensional multi-scale line filter for segmentation and visualization of curvilinear structures in medical images","volume":"2","author":"Sato","year":"1998","journal-title":"Med. Image Anal."},{"key":"2026090107131147700_DEV204945C66","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2026090107131147700_DEV204945C67","doi-asserted-by":"publisher","first-page":"jkae243","DOI":"10.1093\/g3journal\/jkae243","article-title":"Glial peroxisome dysfunction induces axonal swelling and neuroinflammation in Drosophila","volume":"15","author":"Sodders","year":"2025","journal-title":"G3"},{"key":"2026090107131147700_DEV204945C68","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/0092-8674(89)90426-1","article-title":"Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockage","volume":"58","author":"Sosnowski","year":"1989","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C69","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41556-021-00674-1","article-title":"Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila","volume":"23","author":"Tamamouna","year":"2021","journal-title":"Nat. Cell Biol."},{"key":"2026090107131147700_DEV204945C70","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.conb.2016.12.005","article-title":"Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration","volume":"42","author":"Tedeschi","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"2026090107131147700_DEV204945C71","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1083\/jcb.201409025","article-title":"Injury-stimulated Hedgehog signaling promotes regenerative proliferation of Drosophila intestinal stem cells","volume":"208","author":"Tian","year":"2015","journal-title":"J. Cell Biol."},{"key":"2026090107131147700_DEV204945C72","doi-asserted-by":"publisher","first-page":"e110834","DOI":"10.15252\/embj.2022110834","article-title":"Damage-induced regeneration of the intestinal stem cell pool through enteroblast mitosis in the Drosophila midgut","volume":"41","author":"Tian","year":"2022","journal-title":"EMBO J."},{"key":"2026090107131147700_DEV204945C73","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1016\/j.cell.2023.02.022","article-title":"A gut-secreted peptide suppresses arousability from sleep","volume":"186","author":"Titos","year":"2023","journal-title":"Cell"},{"key":"2026090107131147700_DEV204945C74","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1159\/000155983","article-title":"Sex differences in stroke","volume":"26","author":"Turtzo","year":"2008","journal-title":"Cerebrovasc. Dis."},{"key":"2026090107131147700_DEV204945C75","doi-asserted-by":"publisher","first-page":"4147","DOI":"10.1534\/g3.120.401676","article-title":"Analysis of Gal4 expression patterns in adult Drosophila females","volume":"10","author":"Weaver","year":"2020","journal-title":"G3"},{"key":"2026090107131147700_DEV204945C76","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1242\/dev.01928","article-title":"Cellular mechanisms of dendrite pruning in Drosophila: insights from in vivo time-lapse of remodeling dendritic arborizing sensory neurons","volume":"132","author":"Williams","year":"2005","journal-title":"Development"},{"key":"2026090107131147700_DEV204945C77","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1038\/nn1774","article-title":"Local caspase activity directs engulfment of dendrites during pruning","volume":"9","author":"Williams","year":"2006","journal-title":"Nat. Neurosci."},{"key":"2026090107131147700_DEV204945C78","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.chom.2012.03.004","article-title":"Infection-induced intestinal oxidative stress triggers organ-to-organ immunological communication in Drosophila","volume":"11","author":"Wu","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2026090107131147700_DEV204945C79","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/ibd\/izad312","article-title":"Unveiling colitis: a journey through the dextran sodium sulfate-induced model","volume":"30","author":"Yang","year":"2024","journal-title":"Inflamm. Bowel Dis."},{"key":"2026090107131147700_DEV204945C80","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/wdev.241","article-title":"A fly's view of neuronal remodeling","volume":"5","author":"Yaniv","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"2026090107131147700_DEV204945C81","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fnagi.2015.00174","article-title":"Sex differences in stroke subtypes, severity, risk factors, and outcomes among elderly patients with acute ischemic stroke","volume":"7","author":"Yu","year":"2015","journal-title":"Front. Aging Neurosci."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204945\/3682718\/dev204945.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204945\/3685868\/dev204945.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.204945\/3685868\/dev204945.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:13:23Z","timestamp":1788261203000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/4\/dev204945\/370746\/Sex-dependent-plasticity-of-adult-neural-tissue-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,2,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.204945","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.05.05.652027","asserted-by":"object"}]},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"article-number":"dev204945"}}