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The retina is a highly energy-demanding neural tissue, and dysregulation of adenosine metabolism contributes to retinal diseases. Although adenosine pathways form extensive compensatory networks, the dynamics of ecto-5\u2032-nucleotidase (CD73), a key enzyme for extracellular adenosine generation, remain elusive. Here, we map its spatiotemporal profile from development to adulthood using two transgenic mouse lines. We found that CD73 became expressed in the rod-photoreceptor lineage by postnatal day (P) 3 and appeared in the inner nuclear layer from P7 onward. Moreover, CD73 was transiently expressed in the astrocyte lineage between embryonic day 16.5 and P3, and the descendants accumulated in the retinal periphery. Functionally, CD73 deletion delayed rod-response recovery and shortened the implicit time in scotopic electroretinography under dim light. These findings suggest that physiological cues such as light and hypoxia may influence CD73 expression and retinal function. Our work lays the groundwork for investigating how genetic and environmental risk factors may alter adenosine metabolism in retinal diseases.<\/jats:p>","DOI":"10.1242\/dev.205013","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T08:00:56Z","timestamp":1768982456000},"source":"Crossref","is-referenced-by-count":1,"title":["Spatiotemporal dynamics of ecto-5\u2032-nucleotidase (CD73) in mouse retina under physiological conditions"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-6354","authenticated-orcid":false,"given":"Ryutaro","family":"Ishii","sequence":"first","affiliation":[{"name":"Institute of Medicine, University of Tsukuba 1 , Tsukuba 305-8575 ,","place":["Japan"]},{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tsukuba 305-8577 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Institute of Life and Environmental Sciences, University of Tsukuba 3 , Tsukuba 305-8572 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Hosomi","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tsukuba 305-8577 ,","place":["Japan"]},{"name":"Graduate School of Comprehensive Human Sciences, University of Tsukuba 4 Doctoral Program in Human Biology, Comprehensive Human Sciences Research Group , , Tsukuba 305-0006 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9202-8363","authenticated-orcid":false,"given":"Bernd K.","family":"Fleischmann","sequence":"additional","affiliation":[{"name":"Institute of Physiology I 5 , Medical Faculty , , Bonn 53127 ,","place":["Germany"]},{"name":"University of Bonn 5 , Medical Faculty , , Bonn 53127 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6740-5817","authenticated-orcid":false,"given":"Seiya","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Institute of Medicine, University of Tsukuba 1 , Tsukuba 305-8575 ,","place":["Japan"]},{"name":"Transborder Medical Research Center, Institute of Medicine, University of Tsukuba 6 Laboratory Animal Resource Center , , Tsukuba 305-8575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-8865","authenticated-orcid":false,"given":"Kenichi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tsukuba 305-8577 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7576-9186","authenticated-orcid":false,"given":"Hiromi","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba 2 , Tsukuba 305-8577 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"2026020209594514600_DEV205013C1","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.tcb.2021.05.008","article-title":"The elegant complexity of mammalian ecto-5\u2032-nucleotidase (CD73)","volume":"31","author":"Alcedo","year":"2021","journal-title":"Trends Cell Biol."},{"key":"2026020209594514600_DEV205013C2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.preteyeres.2014.01.001","article-title":"The CRB1 and adherens junction complex proteins in retinal development and maintenance","volume":"40","author":"Alves","year":"2014","journal-title":"Prog. 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