{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T12:49:24Z","timestamp":1775566164898,"version":"3.50.1"},"reference-count":44,"publisher":"The Company of Biologists","issue":"7","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"crossref","award":["2022YFA0806603"],"award-info":[{"award-number":["2022YFA0806603"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In vertebrates, neural induction requires the inhibition of BMP signals by dorsal organizer-derived antagonists. However, the underlying mechanism is not completely understood. Here, using zebrafish as a model, we show that ADNP2 orthologs adnp2a and adnp2b are required for proper neural induction in gastrulating embryos. Deficiency of adnp2 causes deficits in neuroectoderm specification, showing reduced expression of both anterior and posterior neural markers. Adnp2 functions as a transcriptional repressor, and directly occupies and suppresses the BMP-related ved\/vent\/vox homeobox genes, thereby excluding their expression from dorsal territories, including the dorsal mesoderm and presumptive neural plate. adnp2-deficient larvae display aberrant behavioral alterations, which can be partially rescued by the administration of BMP antagonist Dorsomorphin or dnBmpr1 mRNAs. Our findings in the zebrafish model reveal an indirect role for Adnp2 in neuroectoderm formation by antagonizing the activities of BMP-related ventralizing genes, which will be useful for understanding neural disorders caused by ADNP2 dysfunction in human.<\/jats:p>","DOI":"10.1242\/dev.205030","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:17:26Z","timestamp":1773393446000},"source":"Crossref","is-referenced-by-count":0,"title":["Adnp2 promotes neural induction by antagonizing the\n                    <i>ved<\/i>\n                    and\n                    <i>vent<\/i>\n                    homeobox genes"],"prefix":"10.1242","volume":"153","author":[{"given":"Yongxin","family":"Wang","sequence":"first","affiliation":[{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences 1 , Beijing 100049 ,","place":["China"]},{"name":"Institute of Hydrobiology 2 , Wuhan, 430072 , ,","place":["PR China"]},{"name":"Chinese Academy of Sciences 2 , Wuhan, 430072 , ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences 1 , Beijing 100049 ,","place":["China"]},{"name":"Institute of Hydrobiology 2 , Wuhan, 430072 , ,","place":["PR China"]},{"name":"Chinese Academy of Sciences 2 , Wuhan, 430072 , ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences 1 , Beijing 100049 ,","place":["China"]},{"name":"Institute of Hydrobiology 2 , Wuhan, 430072 , ,","place":["PR China"]},{"name":"Chinese Academy of Sciences 2 , Wuhan, 430072 , ,","place":["PR China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-9022","authenticated-orcid":false,"given":"Yuhua","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences 1 , Beijing 100049 ,","place":["China"]},{"name":"Institute of Hydrobiology 2 , Wuhan, 430072 , ,","place":["PR China"]},{"name":"Chinese Academy of Sciences 2 , Wuhan, 430072 , ,","place":["PR China"]},{"name":"Hubei Hongshan laboratory 3 , Wuhan 430070 ,","place":["China"]},{"name":"College of Life Sciences, Huzhou University 4 , Huzhou 313000, Zhejiang Province ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"2026040707580666600_DEV205030C1","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1101\/gad.351769.124","article-title":"ChAHP2 and ChAHP control diverse retrotransposons by complementary activities","volume":"38","author":"Ahel","year":"2024","journal-title":"Genes Dev."},{"key":"2026040707580666600_DEV205030C2","doi-asserted-by":"publisher","first-page":"678350","DOI":"10.3389\/fnins.2021.678350","article-title":"Using monozygotic twins to dissect common genes in posttraumatic stress disorder and migraine","volume":"15","author":"Bainomugisa","year":"2021","journal-title":"Front. 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