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Collecting duct (CD) cells expressing the same mutations in the \u03b21 subunit have moderate tubulogenesis, spreading and adhesion defects, but show intact growth factor-dependent signaling. In contrast, mice lacking kindlins in the UB are anephric due to a complete absence of UB budding. Kindlin-knockout CD cells are unable to spread, adhere or respond to growth factors, irrespective of whether the integrins are bound to a ligand. Thus, in addition to regulating integrin function, kindlins mediate crucial growth factor signaling required for initial UB formation.<\/jats:p>","DOI":"10.1242\/dev.205044","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:58:57Z","timestamp":1769414337000},"source":"Crossref","is-referenced-by-count":0,"title":["Kindlins regulate integrin- and growth factor-dependent ureteric bud formation"],"prefix":"10.1242","volume":"153","author":[{"given":"Shensen","family":"Li","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center 1 Division of Nephrology and Hypertension, Department of Medicine , , Nashville, TN 37232 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-2945","authenticated-orcid":false,"given":"Fabian","family":"Bock","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center 1 Division of Nephrology and Hypertension, 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