{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:12:50Z","timestamp":1788264770768,"version":"build-2803163510"},"reference-count":84,"publisher":"The Company of Biologists","issue":"5","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["EY032593"],"award-info":[{"award-number":["EY032593"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS097914"],"award-info":[{"award-number":["NS097914"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["EY024861"],"award-info":[{"award-number":["EY024861"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>After optic nerve injury, several retinal ganglion cell (RGC) intrinsic signaling pathways have been shown to enhance RGC survival and RGC axonal growth. In contrast, few extrinsic cues have been identified that guide regenerating RGC axons toward and across the optic chiasm. Here, we use live-cell imaging in larval zebrafish to show that regrowing RGC axons initiate growth toward the midline and extend along a trajectory similar to their original projection. From a candidate genetic screen, we identify the glycosyltransferase Lh3 (also referred to as Plod3) to be required to direct regrowing RGC axons toward the midline during active regeneration. Moreover, we show that transgenic lh3 expression in sox10+ presumptive olig2+ oligodendrocytes located near the optic chiasm restores directed axonal growth in lh3 mutants. Finally, we find that mutants in collagen 18a1 (col18a1), a putative Lh3 substrate, display RGC axonal misguidance phenotypes similar to lh3 mutants, suggesting that lh3 may act through col18a1 during regeneration. Combined, these data identify lh3 as part of a glial derived molecular pathway that is critical for guiding in vivo regenerating RGC axons toward and across the optic chiasm.<\/jats:p>","DOI":"10.1242\/dev.205048","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T08:41:56Z","timestamp":1769416916000},"source":"Crossref","is-referenced-by-count":2,"title":["A glial cell-derived pathway directs regenerating optic nerve axons toward the optic chiasm"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-5640","authenticated-orcid":false,"given":"Beth M.","family":"Harvey","sequence":"first","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania Department of Cell and Developmental Biology , , Philadelphia, Pennsylvania 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Baxter","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania Department of Cell and Developmental Biology , , Philadelphia, Pennsylvania 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania Department of Cell and Developmental Biology , , Philadelphia, Pennsylvania 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Granato","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania Department of Cell and Developmental Biology , , Philadelphia, Pennsylvania 19104 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"2026090107135210900_DEV205048C1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.brainres.2015.10.011","article-title":"The scales and tales of myelination: using zebrafish and mouse to study myelinating glia","volume":"1641","author":"Ackerman","year":"2016","journal-title":"Brain Res."},{"key":"2026090107135210900_DEV205048C2","doi-asserted-by":"publisher","first-page":"a020453","DOI":"10.1101\/cshperspect.a020453","article-title":"Oligodendrocyte Development and Plasticity","volume":"8","author":"Bergles","year":"2015","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"2026090107135210900_DEV205048C3","doi-asserted-by":"publisher","first-page":"4368","DOI":"10.1523\/JNEUROSCI.14-07-04368.1994","article-title":"Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats","volume":"14","author":"Berkelaar","year":"1994","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.preteyeres.2018.11.006","article-title":"Return of function after CNS axon regeneration: Lessons from injury-responsive intrinsically photosensitive and alpha retinal ganglion cells","volume":"71","author":"Berry","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"2026090107135210900_DEV205048C5","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1126\/science.1098439","article-title":"Cyclic AMP-induced repair of zebrafish spinal circuits","volume":"305","author":"Bhatt","year":"2004","journal-title":"Science"},{"key":"2026090107135210900_DEV205048C6","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s42003-019-0434-2","article-title":"The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons","volume":"2","author":"Bremer","year":"2019","journal-title":"Commun. Biol."},{"key":"2026090107135210900_DEV205048C7","doi-asserted-by":"publisher","first-page":"4096","DOI":"10.1038\/s41467-022-31797-0","article-title":"Microglia coordinate cellular interactions during spinal cord repair in mice","volume":"13","author":"Brennan","year":"2022","journal-title":"Nat. Commun."},{"key":"2026090107135210900_DEV205048C8","doi-asserted-by":"publisher","first-page":"10545","DOI":"10.1073\/pnas.92.23.10545","article-title":"A behavioral screen for isolating zebrafish mutants with visual system defects","volume":"92","author":"Brockerhoff","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107135210900_DEV205048C9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/glia.10088","article-title":"Characterization of myelination in the developing zebrafish","volume":"39","author":"Br\u00f6samle","year":"2002","journal-title":"Glia"},{"key":"2026090107135210900_DEV205048C10","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1749-8104-9-22","article-title":"Axon-Schwann cell interactions during peripheral nerve regeneration in zebrafish larvae","volume":"9","author":"Ceci","year":"2014","journal-title":"Neural Dev."},{"key":"2026090107135210900_DEV205048C11","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/35000219","article-title":"Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1","volume":"403","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"2026090107135210900_DEV205048C12","doi-asserted-by":"publisher","first-page":"dev165753","DOI":"10.1242\/dev.165753","article-title":"Third-generation in situ hybridization chain reaction: multiplexed, quantitative, sensitive, versatile, robust","volume":"145","author":"Choi","year":"2018","journal-title":"Development"},{"key":"2026090107135210900_DEV205048C13","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.ydbio.2007.01.033","article-title":"Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish","volume":"304","author":"Davison","year":"2007","journal-title":"Dev. Biol."},{"key":"2026090107135210900_DEV205048C14","doi-asserted-by":"publisher","first-page":"14198","DOI":"10.1038\/s41598-019-50485-6","article-title":"Cellular reprogramming for successful CNS axon regeneration is driven by a temporally changing cast of transcription factors","volume":"9","author":"Dhara","year":"2019","journal-title":"Sci. Rep."},{"key":"2026090107135210900_DEV205048C15","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1006\/dbio.1996.0335","article-title":"The development of vision in the zebrafish (Danio rerio)","volume":"180","author":"Easter","year":"1996","journal-title":"Dev. Biol."},{"key":"2026090107135210900_DEV205048C16","doi-asserted-by":"publisher","first-page":"876","DOI":"10.3390\/polym14050876","article-title":"The molecular interaction of collagen with cell receptors for biological function","volume":"14","author":"Elango","year":"2022","journal-title":"Polymers"},{"key":"2026090107135210900_DEV205048C17","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1182\/blood-2010-10-314120","article-title":"mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish","volume":"117","author":"Ellett","year":"2011","journal-title":"Blood"},{"key":"2026090107135210900_DEV205048C18","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.expneurol.2007.05.014","article-title":"CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure","volume":"209","author":"Fitch","year":"2008","journal-title":"Exp. Neurol."},{"key":"2026090107135210900_DEV205048C19","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1093\/emboj\/21.7.1535","article-title":"Lack of collagen XVIII\/endostatin results in eye abnormalities","volume":"21","author":"Fukai","year":"2002","journal-title":"EMBO J."},{"key":"2026090107135210900_DEV205048C20","doi-asserted-by":"publisher","first-page":"9294","DOI":"10.1523\/JNEUROSCI.2678-05.2005","article-title":"Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum","volume":"25","author":"Gahtan","year":"2005","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C21","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S0896-6273(02)00602-5","article-title":"Retinal ganglion cells do not extend axons by default: promotion by neurotrophic signaling and electrical activity","volume":"33","author":"Goldberg","year":"2002","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C22","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/35000226","article-title":"Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein","volume":"403","author":"Grandpr\u00e9","year":"2000","journal-title":"Nature"},{"key":"2026090107135210900_DEV205048C23","doi-asserted-by":"publisher","first-page":"e0218667","DOI":"10.1371\/journal.pone.0218667","article-title":"Optic nerve regeneration in larval zebrafish exhibits spontaneous capacity for retinotopic but not tectum specific axon targeting","volume":"14","author":"Harvey","year":"2019","journal-title":"PLoS ONE"},{"key":"2026090107135210900_DEV205048C24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-1-0716-3012-9_10","article-title":"Assaying optic nerve regeneration in larval zebrafish","volume":"2636","author":"Harvey","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"2026090107135210900_DEV205048C25","doi-asserted-by":"publisher","first-page":"36158","DOI":"10.1074\/jbc.M006203200","article-title":"Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity","volume":"275","author":"Heikkinen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026090107135210900_DEV205048C26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnmol.2012.00005","article-title":"Expression of the Wnt signaling system in central nervous system axon guidance and regeneration","volume":"5","author":"Hollis","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"2026090107135210900_DEV205048C27","first-page":"53P","article-title":"The course of recovery of the retinotectal projection during regeneration of the fish optic nerve","volume":"217","author":"Horder","year":"1971","journal-title":"J. Physiol."},{"key":"2026090107135210900_DEV205048C28","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2015.10.004","article-title":"The lh3 glycosyltransferase directs target-selective peripheral nerve regeneration","volume":"88","author":"Isaacman-Beck","year":"2015","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.cub.2004.02.005","article-title":"Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance","volume":"14","author":"Johnson","year":"2004","journal-title":"Curr. Biol."},{"key":"2026090107135210900_DEV205048C30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/nn2025","article-title":"CNS-derived glia ensheath peripheral nerves and mediate motor root development","volume":"11","author":"Kucenas","year":"2008","journal-title":"Nat. Neurosci."},{"key":"2026090107135210900_DEV205048C31","doi-asserted-by":"publisher","first-page":"15654","DOI":"10.1523\/JNEUROSCI.4340-10.2010","article-title":"Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion","volume":"30","author":"Kurimoto","year":"2010","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C32","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000","article-title":"Lens injury stimulates axon regeneration in the mature rat optic nerve","volume":"20","author":"Leon","year":"2000","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C33","doi-asserted-by":"publisher","first-page":"12762","DOI":"10.1523\/JNEUROSCI.1906-14.2014","article-title":"Perineurial glia are essential for motor axon regrowth following nerve injury","volume":"34","author":"Lewis","year":"2014","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C34","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.expneurol.2013.03.001","article-title":"Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury","volume":"247","author":"Luo","year":"2013","journal-title":"Exp. Neurol."},{"key":"2026090107135210900_DEV205048C35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/gigascience\/gix056","article-title":"High-precision registration between zebrafish brain atlases using symmetric diffeomorphic normalization","volume":"6","author":"Marquart","year":"2017","journal-title":"GigaScience"},{"key":"2026090107135210900_DEV205048C36","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1242\/dev.053611","article-title":"Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning","volume":"137","author":"Martin","year":"2010","journal-title":"Development"},{"key":"2026090107135210900_DEV205048C37","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","article-title":"Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth","volume":"13","author":"McKerracher","year":"1994","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C38","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.brainresbull.2020.11.012","article-title":"Myelination of regenerating optic nerve axons occurs in conjunction with an increase of the oligodendrocyte precursor cell population in the adult mice","volume":"166","author":"Mendon\u00e7a","year":"2021","journal-title":"Brain Res. Bull."},{"key":"2026090107135210900_DEV205048C39","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1126\/science.1175737","article-title":"KLF family members regulate intrinsic axon regeneration ability","volume":"326","author":"Moore","year":"2009","journal-title":"Science"},{"key":"2026090107135210900_DEV205048C40","doi-asserted-by":"publisher","first-page":"9229","DOI":"10.1523\/JNEUROSCI.23-27-09229.2003","article-title":"The transmembrane semaphorin Sema4D\/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion","volume":"23","author":"Moreau-Fauvarque","year":"2003","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C41","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/0896-6273(94)90042-6","article-title":"A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration","volume":"13","author":"Mukhopadhyay","year":"1994","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C42","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0960-9822(00)00048-8","article-title":"Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate","volume":"4","author":"Mullins","year":"1994","journal-title":"Curr. Biol."},{"key":"2026090107135210900_DEV205048C43","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1523\/JNEUROSCI.1528-21.2021","article-title":"Robo2 drives target-selective peripheral nerve regeneration in response to glia-derived signals","volume":"42","author":"Murphy","year":"2022","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C44","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1002\/cne.901680202","article-title":"Regeneration of retinal axons into the goldfish optic tectum","volume":"168","author":"Murray","year":"1976","journal-title":"J. Comp. Neurol."},{"key":"2026090107135210900_DEV205048C45","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.devcel.2021.12.008","article-title":"Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection","volume":"57","author":"Nogueira-Rodrigues","year":"2022","journal-title":"Dev. Cell"},{"key":"2026090107135210900_DEV205048C46","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1016\/j.neuron.2017.05.035","article-title":"Sox11 expression promotes regeneration of some retinal ganglion cell types but kills others","volume":"94","author":"Norsworthy","year":"2017","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C47","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"2026090107135210900_DEV205048C48","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1002\/cne.24070","article-title":"Retinal ganglion cell survival and axon regeneration after optic nerve injury in naked mole-rats","volume":"525","author":"Park","year":"2017","journal-title":"J. Comp. Neurol."},{"key":"2026090107135210900_DEV205048C49","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.neuroscience.2016.12.020","article-title":"Wnt signaling promotes axonal regeneration following optic nerve injury in the mouse","volume":"343","author":"Patel","year":"2017","journal-title":"Neuroscience"},{"key":"2026090107135210900_DEV205048C50","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.nbd.2012.11.011","article-title":"Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve","volume":"51","author":"Pernet","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"2026090107135210900_DEV205048C51","doi-asserted-by":"publisher","first-page":"e734","DOI":"10.1038\/cddis.2013.266","article-title":"Misguidance and modulation of axonal regeneration by Stat3 and Rho\/ROCK signaling in the transparent optic nerve","volume":"4","author":"Pernet","year":"2013","journal-title":"Cell Death Dis."},{"key":"2026090107135210900_DEV205048C52","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1242\/dev.025049","article-title":"Pathfinding in a large vertebrate axon tract: isotypic interactions guide retinotectal axons at multiple choice points","volume":"135","author":"Pittman","year":"2008","journal-title":"Development"},{"key":"2026090107135210900_DEV205048C53","doi-asserted-by":"publisher","first-page":"e1878","DOI":"10.1371\/journal.pone.0001878","article-title":"A cryptic frizzled module in cell surface collagen 18 inhibits Wnt\/beta-catenin signaling","volume":"3","author":"Qu\u00e9lard","year":"2008","journal-title":"PLoS ONE"},{"key":"2026090107135210900_DEV205048C54","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nmeth.3581","article-title":"Whole-brain activity mapping onto a zebrafish brain atlas","volume":"12","author":"Randlett","year":"2015","journal-title":"Nat. Methods"},{"key":"2026090107135210900_DEV205048C55","doi-asserted-by":"publisher","first-page":"37535","DOI":"10.1074\/jbc.M405638200","article-title":"Characterization of collagenous peptides bound to lysyl hydroxylase isoforms","volume":"279","author":"Risteli","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2026090107135210900_DEV205048C56","doi-asserted-by":"publisher","first-page":"3898","DOI":"10.1523\/JNEUROSCI.5225-11.2012","article-title":"In vivo nerve-macrophage interactions following peripheral nerve injury","volume":"32","author":"Rosenberg","year":"2012","journal-title":"J. Neurosci."},{"key":"2026090107135210900_DEV205048C57","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/exd.14197","article-title":"Prolyl and lysyl hydroxylases in collagen synthesis","volume":"30","author":"Salo","year":"2021","journal-title":"Exp. Dermatol."},{"key":"2026090107135210900_DEV205048C58","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.neuron.2006.04.024","article-title":"The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration","volume":"50","author":"Schneider","year":"2006","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C59","doi-asserted-by":"publisher","first-page":"eade9909","DOI":"10.1126\/sciadv.ade9909","article-title":"A single-cell resolution gene expression atlas of the larval zebrafish brain","volume":"9","author":"Shainer","year":"2023","journal-title":"Sci. Adv."},{"key":"2026090107135210900_DEV205048C60","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1002\/dneu.20854","article-title":"Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila embryo","volume":"71","author":"Smart","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"2026090107135210900_DEV205048C61","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C62","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.bbrc.2016.07.006","article-title":"Wnt\/\u03b2-catenin signaling promotes regeneration after adult zebrafish spinal cord injury","volume":"477","author":"Strand","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026090107135210900_DEV205048C63","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-60327-019-9_3","article-title":"Transgenesis in zebrafish with the tol2 transposon system","volume":"561","author":"Suster","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"2026090107135210900_DEV205048C64","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1086\/344695","article-title":"Molecular analysis of collagen XVIII reveals novel mutations, presence of a third isoform, and possible genetic heterogeneity in Knobloch syndrome","volume":"71","author":"Suzuki","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"2026090107135210900_DEV205048C65","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ydbio.2019.10.020","article-title":"Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate","volume":"458","author":"Taler","year":"2019","journal-title":"Dev. Biol."},{"key":"2026090107135210900_DEV205048C66","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1146\/annurev.neuro.30.051606.094354","article-title":"Why is Wallerian degeneration in the CNS so slow?","volume":"30","author":"Vargas","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"2026090107135210900_DEV205048C67","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/neu.480240103","article-title":"Rapid and protracted phases of retinal ganglion cell loss follow axotomy in the optic nerve of adult rats","volume":"24","author":"Villegas-P\u00e9rez","year":"1993","journal-title":"J. Neurobiol."},{"key":"2026090107135210900_DEV205048C68","first-page":"369","article-title":"Experiments on the section of the glosso-pharyngeal and hypoglossal nerves of the frog, and observations of the alterations produced thereby in the structure of their primitive fibres","volume":"76","author":"Waller","year":"1851","journal-title":"Edinburgh Med. Surg. J."},{"key":"2026090107135210900_DEV205048C69","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/0896-6273(92)90091-Q","article-title":"A role for proteoglycans in the guidance of a subset of pioneer axons in cultured embryos of the cockroach","volume":"8","author":"Wang","year":"1992","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C70","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0945-053X(02)00071-9","article-title":"The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro","volume":"21","author":"Wang","year":"2002","journal-title":"Matrix Biol."},{"key":"2026090107135210900_DEV205048C71","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/nature00867","article-title":"Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth","volume":"417","author":"Wang","year":"2002","journal-title":"Nature"},{"key":"2026090107135210900_DEV205048C72","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.neuron.2020.09.016","article-title":"Robust myelination of regenerated axons induced by combined manipulations of GPR17 and microglia","volume":"108","author":"Wang","year":"2020","journal-title":"Neuron"},{"key":"2026090107135210900_DEV205048C73","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41467-017-00143-0","article-title":"Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish","volume":"8","author":"Wehner","year":"2017","journal-title":"Nat. Commun."},{"key":"2026090107135210900_DEV205048C74","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1167\/iovs.17-23425","article-title":"Type VII collagen in the human accommodation system: expression in ciliary body, zonules, and lens capsule","volume":"59","author":"Wullink","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2026090107135210900_DEV205048C75","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/nn2002","article-title":"Lamina-specific axonal projections in the zebrafish tectum require the type IV collagen Dragnet","volume":"10","author":"Xiao","year":"2007","journal-title":"Nat. Neurosci."},{"key":"2026090107135210900_DEV205048C76","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.cell.2011.06.016","article-title":"Assembly of lamina-specific neuronal connections by slit bound to type IV collagen","volume":"146","author":"Xiao","year":"2011","journal-title":"Cell"},{"key":"2026090107135210900_DEV205048C77","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.conb.2013.09.002","article-title":"Signaling mechanisms of non-conventional axon guidance cues: the Shh, BMP and Wnt morphogens","volume":"23","author":"Yam","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"2026090107135210900_DEV205048C78","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/978-1-4939-7407-8_16","article-title":"In vitro and in vivo methods for studying retinal ganglion cell survival and optic nerve regeneration","volume":"1695","author":"Yin","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"2026090107135210900_DEV205048C79","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1179\/174313208X284133","article-title":"Repair effect of Wnt3a protein on the contused adult rat spinal cord","volume":"30","author":"Yin","year":"2008","journal-title":"Neurol. Res."},{"key":"2026090107135210900_DEV205048C80","doi-asserted-by":"publisher","first-page":"19587","DOI":"10.1073\/pnas.0907085106","article-title":"Oncomodulin links inflammation to optic nerve regeneration","volume":"106","author":"Yin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026090107135210900_DEV205048C81","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","volume":"7","author":"Yiu","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"2026090107135210900_DEV205048C82","doi-asserted-by":"publisher","first-page":"3461","DOI":"10.1242\/dev.126.15.3461","article-title":"The zebrafish diwanka gene controls an early step of motor growth cone migration","volume":"126","author":"Zeller","year":"1999","journal-title":"Development"},{"key":"2026090107135210900_DEV205048C83","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/dbio.2002.0852","article-title":"Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues","volume":"252","author":"Zeller","year":"2002","journal-title":"Dev. Biol."},{"key":"2026090107135210900_DEV205048C84","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J. Neurosci."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205048\/3682277\/dev205048.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205048\/3688109\/dev205048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205048\/3688109\/dev205048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:13:58Z","timestamp":1788261238000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/5\/dev205048\/370900\/A-glial-cell-derived-pathway-directs-regenerating"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.205048","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.15.618346","asserted-by":"object"}]},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"article-number":"dev205048"}}