{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:27:29Z","timestamp":1786616849365,"version":"build-2736575974"},"reference-count":63,"publisher":"The Company of Biologists","issue":"15","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["518057412"],"award-info":[{"award-number":["518057412"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020639","name":"Bayerische Staatsministerium f\u00fcr Wirtschaft, Landesentwicklung und Energie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020639","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008769","name":"University of W\u00fcrzburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The TRIM28 gene encodes a transcriptional regulator involved in a variety of molecular processes. Inactivation of TRIM28 has been linked to the epithelial subtype of Wilms tumor, the most common pediatric renal malignancy. Therefore, TRIM28 may impact early kidney morphogenesis. To investigate its role in nephrogenesis, we analyzed Trim28 conditional knockout (Trim28\u0394\/\u0394) mice. We found that deleting Trim28 in nephron progenitors resulted in early postnatal lethality and reduced kidney weight. While all renal structures were present, the proximal tubules (PTs) were disorganized. Transcriptome analyses revealed cell type-specific deregulation of retroelement expression following Trim28 deletion. Further analysis of scRNA-seq data revealed a decreased frequency of nephron progenitor cells (NPCs), an increase in PT cells and a clear shift towards inflammatory gene expression patterns. While there was no evidence of tumor formation in Trim28\u0394\/\u0394 kidneys, the differentially expressed genes in Trim28\u0394\/\u0394 progenitors reflected reduced translation, similar to patterns observed in TRIM28 mutant tumor-derived NPCs. Thus, our data demonstrate that TRIM28 primarily influences the maintenance and differentiation of NPCs and PT cells, as well as their subsequent function.<\/jats:p>","DOI":"10.1242\/dev.205188","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:46:36Z","timestamp":1785311196000},"source":"Crossref","is-referenced-by-count":0,"title":["The absence of\n                    <i>Trim28<\/i>\n                    in nephron progenitors results in impaired kidney development and function"],"prefix":"10.1242","volume":"153","author":[{"given":"Balazs","family":"Palhazi","sequence":"first","affiliation":[{"name":"Theodor Boveri-Institute, University of W\u00fcrzburg 1 Department of Developmental Biochemistry , , D-97074 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Paikari","sequence":"additional","affiliation":[{"name":"Theodor Boveri-Institute, University of W\u00fcrzburg 1 Department of Developmental Biochemistry , , D-97074 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Clar\u00e9n","sequence":"additional","affiliation":[{"name":"Theodor Boveri-Institute, University of W\u00fcrzburg 1 Department of Developmental Biochemistry , , D-97074 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Appenzeller","sequence":"additional","affiliation":[{"name":"University Hospital of W\u00fcrzburg 2 Comprehensive Cancer Center Mainfranken , , D-97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Imdahl","sequence":"additional","affiliation":[{"name":"Helmholtz Institute for RNA-based Infection Research (HIRI), Single-Cell Center 3 , D-97076 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Daniel","sequence":"additional","affiliation":[{"name":"Friedrich-Alexander Universit\u00e4t (FAU) Erlangen-N\u00fcrnberg 4 Department of Nephropathology , , D-91054 Erlangen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5690-5453","authenticated-orcid":false,"given":"Matthias","family":"Becker","sequence":"additional","affiliation":[{"name":"Theodor Boveri-Institute, University of W\u00fcrzburg 1 Department of Developmental Biochemistry , , D-97074 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gessler","sequence":"additional","affiliation":[{"name":"Theodor Boveri-Institute, University of W\u00fcrzburg 1 Department of Developmental Biochemistry , , D-97074 W\u00fcrzburg ,","place":["Germany"]},{"name":"University Hospital of W\u00fcrzburg 2 Comprehensive Cancer Center Mainfranken , , D-97080 W\u00fcrzburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026081305314981900_DEV205188C1","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1002\/stem.1130","article-title":"Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury","volume":"30","author":"Angelotti","year":"2012","journal-title":"Stem Cells"},{"key":"2026081305314981900_DEV205188C2","doi-asserted-by":"publisher","first-page":"eadt5553","DOI":"10.1126\/scitranslmed.adt5553","article-title":"Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models","volume":"17","author":"Araoka","year":"2025","journal-title":"Sci. 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