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Secreted lipocalins are lipid transporters frequently found within apical compartments. We show that loss of the Caenorhabditis elegans lipocalin LPR-1 disrupts the assembly of another lipocalin, LPR-3, within the pre-cuticle aECM that protects and shapes the narrow excretory duct and pore tubes. Loss of SCAV-2, a CD36 family scavenger receptor, restored LPR-3 matrix localization and suppressed the tube shaping defects of lpr-1 and a subset of pre-cuticle mutants, but not lpr-3 mutants. SCAV-2 accumulates at duct and pore apical surfaces and functions locally within these tubes. These data demonstrate that LPR-1 and SCAV-2 have opposing effects on narrow tube integrity by altering the content and organization of the luminal aECM of the tube, possibly by acting as transporters of LPR-3 or an LPR-3 cofactor. These results have broadly relevant implications regarding the importance of lipocalins and scavenger receptors for aECM organization and integrity of the narrowest tubes in the body.<\/jats:p>","DOI":"10.1242\/dev.205309","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:13:51Z","timestamp":1764159231000},"source":"Crossref","is-referenced-by-count":4,"title":["Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-5085","authenticated-orcid":false,"given":"Alexandra C.","family":"Belfi","sequence":"first","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sage G.","family":"Aviles","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1853-9456","authenticated-orcid":false,"given":"Rachel","family":"Forman-Rubinsky","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0718-5920","authenticated-orcid":false,"given":"Hasreet K.","family":"Gill","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-7666","authenticated-orcid":false,"given":"Jennifer D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1488-7622","authenticated-orcid":false,"given":"Aleksandra","family":"Nawrocka","sequence":"additional","affiliation":[{"name":"ULB Institute for Neuroscience, Universit\u00e9 libre de Bruxelles 2 Laboratory of Neurophysiology , , 1070 Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-381X","authenticated-orcid":false,"given":"Axelle","family":"Bourez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 libre de Bruxelles 3 RD3-Pharmacognosy, Bioanalysis and Drug Discovery and Analytical Platform of the Faculty of Pharmacy , , 1050 Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4934-8863","authenticated-orcid":false,"given":"Pierre","family":"van Antwerpen","sequence":"additional","affiliation":[{"name":"Universit\u00e9 libre de Bruxelles 3 RD3-Pharmacognosy, Bioanalysis and Drug Discovery and Analytical Platform of the Faculty of Pharmacy , , 1050 Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5360-5597","authenticated-orcid":false,"given":"Patrick","family":"Laurent","sequence":"additional","affiliation":[{"name":"ULB Institute for Neuroscience, Universit\u00e9 libre de Bruxelles 2 Laboratory of Neurophysiology , , 1070 Bruxelles ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-8750","authenticated-orcid":false,"given":"Meera V.","family":"Sundaram","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine 1 Department of Genetics , , Philadelphia, PA 19104,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"2026011209325562200_DEV205309C1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/bs.ctm.2023.02.004","article-title":"Setting the stage for universal pharmacological targeting of the glycocalyx","volume":"91","author":"Almahayni","year":"2023","journal-title":"Curr. 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