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Here, we have used the zebrafish posterior lateral line primordium (pLLP) as a model for epithelial collective cell migration. We show that integrins \u03b13 and \u03b16b are expressed in different, yet overlapping, domains of the pLLP and function redundantly to support migration. The systematic combination of itga6b, itga3b and itga3a mutants disrupts integrin \u03b21 localization, increases protrusive activity and impairs migration, revealing a spatially organized, partially redundant adhesion system. We further identify laminin \u03b15 (Lama5) as a key component of the basement membrane (BM) underlying the migrating pLLP. While loss of Lama5 alone compromises BM integrity and pLLP morphology without impairing migration, simultaneous depletion of lama5 and itga6b leads to severe migration defects, with the formation of invadopodia-like structures and ultimately the stalling of migration. Together, these findings reveal a robust, redundant adhesion machinery that ensures persistent collective migration in vivo, and they establish fundamental principles of integrin-mediated adhesion that are relevant to development and disease.<\/jats:p>","DOI":"10.1242\/dev.205312","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:44:30Z","timestamp":1781185470000},"source":"Crossref","is-referenced-by-count":1,"title":["Laminin \u03b15 and integrins \u03b13 and \u03b16 coordinately regulate collective cell migration\n                    <i>in vivo<\/i>"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6573-817X","authenticated-orcid":false,"given":"Anna","family":"Mertens","sequence":"first","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , 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Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5116-4721","authenticated-orcid":false,"given":"Chaitanya","family":"Dingare","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Institute for Biology I 2 Developmental Biology , , Faculty of Biology , , Freiburg im Breisgau 79104,","place":["Germany"]},{"name":"Albert-Ludwigs-Universit\u00e4t Freiburg 2 Developmental Biology , , Faculty of Biology , , Freiburg im Breisgau 79104,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Heyde","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Basoglu","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eimer","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-3425","authenticated-orcid":false,"given":"Virginie","family":"Lecaudey","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Neuroscience 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Goethe Universit\u00e4t Frankfurt 1 , Faculty of Biosciences , , Frankfurt am Main 60438,","place":["Germany"]},{"name":"Institute for Biology I 2 Developmental Biology , , Faculty of Biology , , Freiburg im Breisgau 79104,","place":["Germany"]},{"name":"Albert-Ludwigs-Universit\u00e4t Freiburg 2 Developmental Biology , , Faculty of Biology , , Freiburg im Breisgau 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