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Because most PCP mouse models die at birth, orientation defects have been studied mainly at fetal stages. Using viable conditional mutants lacking both Vangl1 and Vangl2, or Fzd3 and Fzd6, we show that misoriented auditory hair cells undergo extensive postnatal reorientation, largely correcting defects over time. These findings extend previous observations in Vangl2 single conditional mutants and demonstrate that correction does not require redundant core PCP partners. GPR156, a receptor that reverses how PCP signaling is interpreted in some hair cell types, is also essential for orientation but Gpr156 mutants fail to correct defects. We therefore tested its role in core PCP mutant recovery. GPR156 binds and depends on VANGL proteins, yet inhibiting GPR156 signaling facilitates rather than prevents correction in Vangl and Fzd mutants. Thus, GPR156 collaborates with core PCP components to establish hair cell orientation but is dispensable \u2013 and even inhibitory \u2013 for postnatal realignment. These findings reveal extensive plasticity in hair cell orientation and identify GPR156 as a context-dependent partner of core PCP proteins.<\/jats:p>","DOI":"10.1242\/dev.205332","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:09:56Z","timestamp":1777622996000},"source":"Crossref","is-referenced-by-count":1,"title":["Progressive correction of auditory hair cell orientation in the absence of core planar cell polarity and GPR156 signaling"],"prefix":"10.1242","volume":"153","author":[{"given":"Amandine","family":"Jarysta","sequence":"first","affiliation":[{"name":"The Jackson Laboratory 1 , Bar Harbor, ME 04609 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Nemelka","sequence":"additional","affiliation":[{"name":"Spencer Fox Eccles School of Medicine at the University of Utah 2 Department of Neurobiology , , Salt Lake City, UT 84112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthumeena","family":"Ramanathan","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory 1 , Bar Harbor, ME 04609 ,","place":["USA"]},{"name":"Graduate School of Biomedical Science and Engineering, University of Maine 3 , Orono, ME 04469 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellison J.","family":"Goodrich","sequence":"additional","affiliation":[{"name":"Spencer Fox Eccles School of Medicine at the University of Utah 2 Department of Neurobiology , , Salt Lake City, UT 84112 ,","place":["USA"]},{"name":"Emory University School of Medicine 4 Department of Cell Biology , , Atlanta, GA 30322 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna L.","family":"Vonderhaar","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 5 Department of Pharmacology and Physiology , , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungjin","family":"Park","sequence":"additional","affiliation":[{"name":"Spencer Fox Eccles School of Medicine at the University of Utah 2 Department of Neurobiology , , Salt Lake City, UT 84112 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Orlandi","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center 5 Department of Pharmacology and Physiology , , Rochester, NY 14642 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Deans","sequence":"additional","affiliation":[{"name":"Spencer Fox Eccles School of Medicine at the University of Utah 2 Department of Neurobiology , , Salt Lake City, UT 84112 ,","place":["USA"]},{"name":"Emory University School of Medicine 4 Department of Cell Biology , , Atlanta, GA 30322 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-6273","authenticated-orcid":false,"given":"Basile","family":"Tarchini","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory 1 , Bar Harbor, ME 04609 ,","place":["USA"]},{"name":"Tufts University School of Medicine 6 , Boston, MA 02111 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026051406375184400_DEV205332C1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ceb.2016.08.002","article-title":"Planar cell polarity: global inputs establishing cellular asymmetry","volume":"44","author":"Aw","year":"2017","journal-title":"Curr. 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