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Recent studies have reported aberrant cartilage formation near affected sutures, suggesting a previously unrecognized role for cartilage in suture morphogenesis and maintenance. The tectum transversum (TTR), a transient cartilage adjacent to the coronal suture, has been considered absent in humans. By analyzing published human embryonic datasets, we demonstrate that the TTR is in fact a conserved structure in humans. We further investigated the developmental dynamics and function of the TTR in mice. Spatial transcriptomic analyses reveal that the TTR mediates critical tissue\u2013tissue interactions and may serve as a physical and molecular barrier restricting BMP signaling activation within the coronal suture, potentially modulated by the underlying dura mater. These findings identify the TTR as a conserved regulator of coronal suture morphogenesis and provide new mechanistic insight into the etiology of coronal craniosynostosis.<\/jats:p>","DOI":"10.1242\/dev.205347","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:27:07Z","timestamp":1781684827000},"source":"Crossref","is-referenced-by-count":1,"title":["The tectum transversum maintains patency of the developing coronal suture"],"prefix":"10.1242","volume":"153","author":[{"given":"Meenakshi","family":"Umar","sequence":"first","affiliation":[{"name":"Tulane University 1 Department of Cell and Molecular Biology , , New Orleans, LA 70118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3168-8781","authenticated-orcid":false,"given":"Garrett","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Tulane University 1 Department of Cell and Molecular Biology , , New Orleans, LA 70118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Sokolowskei","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 2 Department of Surgery , , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Janser","sequence":"additional","affiliation":[{"name":"Tulane University 1 Department of Cell and Molecular Biology , , New Orleans, LA 70118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-5758","authenticated-orcid":false,"given":"Robert J.","family":"Tower","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 2 Department of Surgery , , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4717-8001","authenticated-orcid":false,"given":"Fenglei","family":"He","sequence":"additional","affiliation":[{"name":"Tulane University 1 Department of Cell and Molecular Biology , , New Orleans, LA 70118 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"2026061704270136600_DEV205347C1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1046\/j.1432-0436.2003.7108003.x","article-title":"Nasal capsular cartilage is required for rat transpalatal suture morphogenesis","volume":"71","author":"Adab","year":"2003","journal-title":"Differentiation"},{"key":"2026061704270136600_DEV205347C2","doi-asserted-by":"publisher","first-page":"e2863","DOI":"10.1371\/journal.pone.0002863","article-title":"Induction of Olig2+ precursors by FGF involves BMP signalling blockade at the Smad level","volume":"3","author":"Bilican","year":"2008","journal-title":"PLoS ONE"},{"key":"2026061704270136600_DEV205347C3","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1097\/00006534-199710000-00001","article-title":"Studies in cranial suture biology: regional dura mater determines in vitro cranial suture fusion","volume":"100","author":"Bradley","year":"1997","journal-title":"Plast. 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