{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:10:46Z","timestamp":1788487846998,"version":"build-2803163510"},"reference-count":59,"publisher":"The Company of Biologists","issue":"16","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"crossref","award":["TKP2021-EGA-25"],"award-info":[{"award-number":["TKP2021-EGA-25"]}],"id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010024","name":"Hungarian Science Foundation","doi-asserted-by":"crossref","award":["K-138664"],"award-info":[{"award-number":["K-138664"]}],"id":[{"id":"10.13039\/501100010024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Culture and Innovation","award":["2025-2.1.1-EK\u00d6P-2025-00014"],"award-info":[{"award-number":["2025-2.1.1-EK\u00d6P-2025-00014"]}]},{"name":"National Biomedical Foundation"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01DK119210"],"award-info":[{"award-number":["R01DK119210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["F32DK131792"],"award-info":[{"award-number":["F32DK131792"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Enteric nervous system development relies on migration, proliferation and differentiation of enteric neural crest-derived cells (ENCDCs), processes that are regulated by mesenchymal morphogens and the extracellular matrix (ECM). Hirschsprung disease (HD) is a congenital neurocristopathy in which abnormal gut motility results from loss of ENCDC-derived enteric ganglia in the colorectum. While enteric neural stem cell transplantation is a proposed therapy, current efforts are limited by poor cell migration in HD models. To address this, we investigated ECM-derived inhibitory cues on enteric neural stem cell transplantation efficiency. Immunohistochemistry of embryonic chick hindgut reveals dynamic chondroitin sulfate proteoglycan (CSPG) expression during development. In vitro assays show that CSPGs inhibit ENCDC migration, an effect reversed by chondroitinase ABC. Transplantation of enteric neurospheres into chick and mouse colon results in limited engraftment, but chondroitinase ABC significantly enhances migration of transplanted cells. Single-cell RNA sequencing of postnatal mouse neurospheres reveals high expression of CD44, a transmembrane glycoprotein that can act as a functional CSPG on the cell surface. Blocking CD44 function promotes neurosphere-derived ENCDC migration. Modulating inhibitory ECM components may enhance the success of regenerative therapies for HD.<\/jats:p>","DOI":"10.1242\/dev.205625","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:05:16Z","timestamp":1787655916000},"source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of chondroitin sulfate proteoglycans enhances cell migration following enteric neural stem cell transplantation"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7724-5474","authenticated-orcid":false,"given":"Em\u0151ke","family":"Sz\u0151cs","sequence":"first","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School 2 Department of Pediatric Surgery , , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csenge","family":"Jurenka","sequence":"additional","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1166-6578","authenticated-orcid":false,"given":"R\u00e9ka Borb\u00e1la","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Halasy","sequence":"additional","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Hotta","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School 2 Department of Pediatric Surgery , , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"So\u00f3s","sequence":"additional","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School 2 Department of Pediatric Surgery , , Boston, MA 02114 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-5214","authenticated-orcid":false,"given":"N\u00e1ndor","family":"Nagy","sequence":"additional","affiliation":[{"name":"Semmelweis University 1 Department of Anatomy, Histology and Embryology, Faculty of Medicine , , Budapest 1094 ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026082510561119700_DEV205625C1","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ydbio.2013.08.006","article-title":"Enteric neural crest-derived cells promote their migration by modifying their microenvironment through tenascin-C production","volume":"382","author":"Akbareian","year":"2013","journal-title":"Dev. Biol."},{"key":"2026082510561119700_DEV205625C2","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/(SICI)1097-0134(20000501)39:2&lt;103::AID-PROT1&gt;3.0.CO;2-G","article-title":"Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions","volume":"39","author":"Bajorath","year":"2000","journal-title":"Proteins"},{"key":"2026082510561119700_DEV205625C3","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0896-6273(03)00730-X","article-title":"Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET","volume":"40","author":"Barlow","year":"2003","journal-title":"Neuron"},{"key":"2026082510561119700_DEV205625C4","doi-asserted-by":"publisher","first-page":"P10008","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","volume":"2008","author":"Blondel","year":"2008","journal-title":"J. Stat. Mech. Theory Exp."},{"key":"2026082510561119700_DEV205625C5","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1038\/s41467-019-11707-7","article-title":"Moving beyond the glial scar for spinal cord repair","volume":"10","author":"Bradbury","year":"2019","journal-title":"Nat. Commun."},{"key":"2026082510561119700_DEV205625C6","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/416636a","article-title":"Chondroitinase ABC promotes functional recovery after spinal cord injury","volume":"416","author":"Bradbury","year":"2002","journal-title":"Nature"},{"key":"2026082510561119700_DEV205625C7","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1242\/dev.02346","article-title":"Lack of \u03b21 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype","volume":"133","author":"Breau","year":"2006","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C8","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1242\/dev.031419","article-title":"\u03b21 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells","volume":"136","author":"Breau","year":"2009","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/jdb9020012","article-title":"Mutation in the ciliary protein C2CD3 reveals organ-specific mechanisms of Hedgehog signal transduction in avian embryos","volume":"9","author":"Brooks","year":"2021","journal-title":"J. Dev. Biol."},{"key":"2026082510561119700_DEV205625C60","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1111\/nmo.12635","article-title":"Endoscopic delivery of enteric neural stem cells to treat Hirschsprung disease","volume":"27","author":"Cheng","year":"2015","journal-title":"Neurogastroenterol. Motil."},{"key":"2026082510561119700_DEV205625C10","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/pr.2017.4","article-title":"Postnatal human enteric neuronal progenitors can migrate, differentiate, and proliferate in embryonic and postnatal aganglionic gut environments","volume":"81","author":"Cheng","year":"2017","journal-title":"Pediatr. Res."},{"key":"2026082510561119700_DEV205625C11","doi-asserted-by":"publisher","first-page":"20927","DOI":"10.1038\/srep20927","article-title":"How tissue mechanical properties affect enteric neural crest cell migration","volume":"6","author":"Chevalier","year":"2016","journal-title":"Sci. Rep."},{"key":"2026082510561119700_DEV205625C12","doi-asserted-by":"publisher","first-page":"5810","DOI":"10.1523\/JNEUROSCI.19-14-05810.1999","article-title":"Robust regeneration of adult sensory axons in degenerating white matter of the adult rat spinal cord","volume":"19","author":"Davies","year":"1999","journal-title":"J. Neurosci."},{"key":"2026082510561119700_DEV205625C13","doi-asserted-by":"publisher","first-page":"757646","DOI":"10.3389\/fnmol.2021.757646","article-title":"TALPID3\/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human","volume":"14","author":"Delalande","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"2026082510561119700_DEV205625C14","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.ydbio.2009.02.024","article-title":"Aggrecan modulation of growth plate morphogenesis","volume":"329","author":"Domowicz","year":"2009","journal-title":"Dev. Biol"},{"key":"2026082510561119700_DEV205625C15","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1242\/dev.031302","article-title":"Age-dependent changes in the gut environment restrict the invasion of the hindgut by enteric neural progenitors","volume":"136","author":"Druckenbrod","year":"2009","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C16","doi-asserted-by":"publisher","first-page":"12123","DOI":"10.1074\/jbc.M510834200","article-title":"Versican V0 and V1 guide migratory neural crest cells","volume":"281","author":"Dutt","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2026082510561119700_DEV205625C17","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1158\/0008-5472.CAN-12-2749","article-title":"CD40-mediated activation of chronic lymphocytic leukemia cells promotes their CD44-dependent adhesion to hyaluronan and restricts CCL21-induced motility","volume":"73","author":"Girbl","year":"2013","journal-title":"Cancer Res."},{"key":"2026082510561119700_DEV205625C18","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1074\/jbc.274.4.2511","article-title":"Characterization of the heparan sulfate and chondroitin sulfate assembly sites in CD44","volume":"274","author":"Greenfield","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2026082510561119700_DEV205625C19","doi-asserted-by":"publisher","first-page":"112194","DOI":"10.1016\/j.celrep.2023.112194","article-title":"Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis","volume":"42","author":"Guyer","year":"2023","journal-title":"Cell Rep."},{"key":"2026082510561119700_DEV205625C20","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1172\/JCI118702","article-title":"CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix","volume":"97","author":"Henke","year":"1996","journal-title":"J. Clin. Investig."},{"key":"2026082510561119700_DEV205625C21","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/nmo.12744","article-title":"Isogenic enteric neural progenitor cells can replace missing neurons and glia in mice with Hirschsprung disease","volume":"28","author":"Hotta","year":"2016","journal-title":"Neurogastroenterol. Motil."},{"key":"2026082510561119700_DEV205625C22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13287-023-03469-3","article-title":"Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice","volume":"14","author":"Hotta","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"2026082510561119700_DEV205625C23","doi-asserted-by":"publisher","first-page":"dev201934","DOI":"10.1242\/dev.201934","article-title":"Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate","volume":"151","author":"Hutchings","year":"2024","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C24","doi-asserted-by":"publisher","first-page":"5982","DOI":"10.1074\/jbc.M507130200","article-title":"Identification and functions of chondroitin sulfate in the milieu of neural stem cells","volume":"281","author":"Ida","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2026082510561119700_DEV205625C25","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1083\/jcb.128.4.673","article-title":"Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon","volume":"128","author":"Jackson","year":"1995","journal-title":"J. Cell Biol."},{"key":"2026082510561119700_DEV205625C26","doi-asserted-by":"publisher","first-page":"35448","DOI":"10.1074\/jbc.M003387200","article-title":"Binding of a large chondroitin sulfate\/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44","volume":"275","author":"Kawashima","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026082510561119700_DEV205625C27","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1006\/dbio.1997.8731","article-title":"Isolation and characterization of chondroitin sulfate proteoglycans from embryonic quail that influence neural crest cell behavior","volume":"192","author":"Kerr","year":"1997","journal-title":"Dev. Biol."},{"key":"2026082510561119700_DEV205625C28","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1158\/1541-7786.MCR-08-0207","article-title":"CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance","volume":"7","author":"Klingbeil","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"2026082510561119700_DEV205625C29","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1242\/dev.120.9.2637","article-title":"The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development","volume":"120","author":"Kurtz","year":"1994","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3233\/RNN-2008-00439","article-title":"Proteoglycans in the central nervous system: plasticity, regeneration and their stimulation with chondroitinase ABC","volume":"26","author":"Kwok","year":"2008","journal-title":"Restor. Neurol. Neurosci."},{"key":"2026082510561119700_DEV205625C31","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1053\/j.gastro.2008.03.035","article-title":"Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon","volume":"135","author":"Lindley","year":"2008","journal-title":"Gastroenterology"},{"key":"2026082510561119700_DEV205625C32","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2026082510561119700_DEV205625C33","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41586-025-09208-3","article-title":"Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice","volume":"645","author":"Majd","year":"2025","journal-title":"Nature"},{"key":"2026082510561119700_DEV205625C34","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.stemcr.2016.12.013","article-title":"Exposure to GDNF enhances the ability of enteric neural progenitors to generate an enteric nervous system","volume":"8","author":"McKeown","year":"2017","journal-title":"Stem Cell Rep."},{"key":"2026082510561119700_DEV205625C35","doi-asserted-by":"publisher","first-page":"14787","DOI":"10.1038\/ncomms14787","article-title":"The soft mechanical signature of glial scars in the central nervous system","volume":"8","author":"Moeendarbary","year":"2017","journal-title":"Nat. Commun."},{"key":"2026082510561119700_DEV205625C36","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/s41572-023-00465-y","article-title":"Hirschsprung disease","volume":"9","author":"Montalva","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026082510561119700_DEV205625C37","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41593-020-00736-x","article-title":"Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing","volume":"24","author":"Morarach","year":"2021","journal-title":"Nat. Neurosci."},{"key":"2026082510561119700_DEV205625C38","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/stcltm\/szae013","article-title":"Agrin inhibition in enteric neural stem cells enhances their migration following colonic transplantation","volume":"13","author":"Mueller","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"2026082510561119700_DEV205625C39","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/ni.3330","article-title":"A septin requirement differentiates autonomous and contact-facilitated T cell proliferation","volume":"17","author":"Mujal","year":"2016","journal-title":"Nat. Immunol."},{"key":"2026082510561119700_DEV205625C40","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ydbio.2006.01.032","article-title":"Endothelin-3 regulates neural crest cell proliferation and differentiation in the hindgut enteric nervous system","volume":"293","author":"Nagy","year":"2006","journal-title":"Dev. Biol."},{"key":"2026082510561119700_DEV205625C41","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.semcdb.2017.01.006","article-title":"Enteric nervous system development: a crest cell's journey from neural tube to colon","volume":"66","author":"Nagy","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"2026082510561119700_DEV205625C42","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.ydbio.2009.03.025","article-title":"Endothelial cells promote migration and proliferation of enteric neural crest cells via \u03b21 integrin signaling","volume":"330","author":"Nagy","year":"2009","journal-title":"Dev. Biol."},{"key":"2026082510561119700_DEV205625C43","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1242\/dev.128132","article-title":"Sonic hedgehog controls enteric nervous system development by patterning the extracellular matrix","volume":"143","author":"Nagy","year":"2016","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C44","doi-asserted-by":"publisher","first-page":"dev160317","DOI":"10.1242\/dev.160317","article-title":"Collagen 18 and agrin are secreted by enteric neural crest cells to remodel their microenvironment and regulate their migration during ENS development","volume":"145","author":"Nagy","year":"2018","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C45","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1242\/dev.126.1.157","article-title":"Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture","volume":"126","author":"Natarajan","year":"1999","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C46","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000147776","article-title":"Extracellular matrix and adhesive molecules in the early development of the gut and its innervation in normal and Spotting Lethal rat embryos","volume":"154","author":"Newgreen","year":"1995","journal-title":"Cells Tissues Organs"},{"key":"2026082510561119700_DEV205625C47","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1038\/s41467-024-46793-9","article-title":"Autologous cell transplantation for treatment of colorectal aganglionosis in mice","volume":"15","author":"Pan","year":"2024","journal-title":"Nat. Commun."},{"key":"2026082510561119700_DEV205625C48","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1242\/dev.127.13.2823","article-title":"Avian neural crest cell migration is diversely regulated by the two major hyaluronan-binding proteoglycans PG-M\/versican and aggrecan","volume":"127","author":"Perissinotto","year":"2000","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C49","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/nrm1004","article-title":"CD44: from adhesion molecules to signalling regulators","volume":"4","author":"Ponta","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026082510561119700_DEV205625C50","doi-asserted-by":"publisher","first-page":"e179755","DOI":"10.1172\/jci.insight.179755","article-title":"Enteric neural stem cell transplant restores gut motility in mice with Hirschsprung disease","volume":"9","author":"Rahman","year":"2024","journal-title":"JCI Insight"},{"key":"2026082510561119700_DEV205625C51","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1242\/dev.02871","article-title":"Chondroitin sulfate glycosaminoglycans control proliferation, radial glia cell differentiation and neurogenesis in neural stem\/progenitor cells","volume":"134","author":"Sirko","year":"2007","journal-title":"Development"},{"key":"2026082510561119700_DEV205625C52","doi-asserted-by":"publisher","first-page":"1681844","DOI":"10.3389\/fcell.2025.1681844","article-title":"Cecal growth factors promote enteric neurosphere formation and hindgut colonization in the avian model","volume":"13","author":"So\u00f3s","year":"2025","journal-title":"Front. Cell Dev. Biol."},{"key":"2026082510561119700_DEV205625C53","doi-asserted-by":"publisher","first-page":"4483","DOI":"10.1172\/JCI83178","article-title":"A collagen VI\u2013dependent pathogenic mechanism for Hirschsprung's disease","volume":"125","author":"Soret","year":"2015","journal-title":"J. Clin. Investig."},{"key":"2026082510561119700_DEV205625C54","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"2026082510561119700_DEV205625C55","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/cne.902910303","article-title":"Distribution of hyaluronic acid and chondroitin sulfate proteoglycans in the presumptive aganglionic terminal bowel of ls\/ls fetal Mice: An ultrastructural analysis","volume":"291","author":"Tennyson","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"2026082510561119700_DEV205625C56","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0014-4800(03)00053-4","article-title":"Motility of colon cancer cells: modulation by CD44 isoform expression","volume":"75","author":"Wong","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"2026082510561119700_DEV205625C57","doi-asserted-by":"publisher","first-page":"8496","DOI":"10.1523\/JNEUROSCI.0632-18.2018","article-title":"Increased synthesis of chondroitin sulfate proteoglycan promotes adult hippocampal neurogenesis in response to enriched environment","volume":"38","author":"Yamada","year":"2018","journal-title":"J. Neurosci."},{"key":"2026082510561119700_DEV205625C58","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1006\/dbio.2000.0100","article-title":"GDNF is a chemoattractant for enteric neural cells","volume":"229","author":"Young","year":"2001","journal-title":"Dev. Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205625\/3713434\/dev205625.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205625\/3713434\/dev205625.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:57:15Z","timestamp":1787669835000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/16\/dev205625\/372640\/Inhibition-of-chondroitin-sulfate-proteoglycans"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":59,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.205625","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,15]]},"article-number":"dev205625"}}