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Current understanding proposes that squamous and secretory cells of the mouse cervicovaginal epithelium arise from a common Trp63+ progenitor. By contrast, in humans, a Krt8+ progenitor gives rise to endocervical secretory cells, whereas a Trp63+ progenitor gives rise to squamous cells in the ectocervix and vagina. We identify a population of Krt8+Trp63\u2212 epithelia that is retained in the mouse cervicovaginal epithelium during postnatal development and adulthood, with olfactomedin 4 (Olfm4) as a specific marker of this lineage. Adult lineage tracing and marker assessment during postnatal development support a revised model in which two epithelial progenitors are delineated by postnatal day 15. Olfm4+ progenitors give rise to goblet cells, while Trp63+ progenitors give rise to keratinocytes in the cervicovaginal canal. Consistent with goblet cell expansion in pregnancy, Olfm4+ progenitors proliferate in early gestation and progesterone promotes their differentiation. These findings reveal a previously unrecognized similarity between mice and humans in which goblet and keratinized cell subtypes are derived from two independent progenitor populations.<\/jats:p>","DOI":"10.1242\/dev.205710","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:51:55Z","timestamp":1790063515000},"source":"Crossref","is-referenced-by-count":1,"title":["Olfactomedin 4 marks progenitor cells that give rise to the secretory cell lineage in the mouse cervix"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-4214","authenticated-orcid":false,"given":"ShanmugaPriyaa","family":"Madhukaran","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgenia","family":"Fomina","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govindkumar","family":"Balagannavar","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Payne","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Wilson","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]},{"name":"University of Texas Southwestern Medical Center 3 Department of Bioinformatics , , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-0391","authenticated-orcid":false,"given":"Gary","family":"Hon","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]},{"name":"University of Texas Southwestern Medical Center 3 Department of Bioinformatics , , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Florian","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-6727","authenticated-orcid":false,"given":"Mala","family":"Mahendroo","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center 1 Department of Obstetrics and Gynecology , , Dallas, TX 75390 ,","place":["USA"]},{"name":"Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center 2 , Dallas, TX 75390 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"2026101304415516600_DEV205710C1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. 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