{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T15:19:05Z","timestamp":1778167145370,"version":"3.51.4"},"reference-count":4,"publisher":"The Company of Biologists","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>Intracytoplasmic sperm injection (ICSI) is a common form of assisted reproductive technology that circumvents male fertility issues around sperm production by directly injecting a sperm cell into the cytoplasm of the egg to induce fertilisation. However, the effect of the ICSI procedure on subsequent generations is unclear. In a new study, Mito Kanatsu-Shinohara and colleagues show that the offsprings of ICSI-derived male mice demonstrate inflammation and oxidative stress across multiple organs during embryonic development \u2013 including the brain, heart and placenta \u2013 leading to higher rates of miscarriage. To learn more about the people behind this paper and how this story developed, we spoke to Mito Kanatsu-Shinohara, Assistant Professor in the Molecular Genetics Laboratory at the Graduate School of Medicine and Faculty of Medicine, Kyoto University, Japan.<\/jats:p>","DOI":"10.1242\/dev.205753","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:47:34Z","timestamp":1778165254000},"source":"Crossref","is-referenced-by-count":0,"title":["The people behind the papers \u2013 Mito Kanatsu-Shinohara"],"prefix":"10.1242","volume":"153","member":"237","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"2026050710472518400_DEV205753C1","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1242\/dev.122.3.823","article-title":"In vitro analysis of epiblast tissue potency for hematopoietic cell differentiation","volume":"122","author":"Kanatsu","year":"1996","journal-title":"Development"},{"key":"2026050710472518400_DEV205753C2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1095\/biolreprod.103.017012","article-title":"Long-term proliferation in culture and germline transmission of mouse male germline stem cells","volume":"69","author":"Kanatsu-Shinohara","year":"2003","journal-title":"Biol. Reprod."},{"key":"2026050710472518400_DEV205753C3","doi-asserted-by":"publisher","first-page":"e170140","DOI":"10.1172\/JCI170140","article-title":"Intracytoplasmic sperm injection induces transgenerational abnormalities in mice","volume":"133","author":"Kanatsu-Shinohara","year":"2023","journal-title":"J. Clin. Invest."},{"key":"2026050710472518400_DEV205753C4","doi-asserted-by":"publisher","first-page":"dev205500","DOI":"10.1242\/dev.205500","article-title":"Mouse ICSI impairs fertility of male offspring by disruption of fetomaternal tolerance","volume":"153","author":"Kanatsu-Shinohara","year":"2026","journal-title":"Development"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205753\/3698105\/dev205753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205753\/3698105\/dev205753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T14:47:34Z","timestamp":1778165254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/9\/dev205753\/371631\/The-people-behind-the-papers-Mito-Kanatsu"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":4,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.205753","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"article-number":"dev205753"}}