{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:00:06Z","timestamp":1790769606347,"version":"4.1.0"},"reference-count":91,"publisher":"The Company of Biologists","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","id":[{"id":"https:\/\/ror.org\/03cqe8w59","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Company of Biologists","id":[{"id":"https:\/\/ror.org\/0033z1132","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundaci\u00f3n Cient\u00edfica Felipe Fiorellino"},{"name":"Universidad Maim\u00f3nides","id":[{"id":"https:\/\/ror.org\/01tkmq646","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institutes of Health","award":["R01GM157825"],"award-info":[{"award-number":["R01GM157825"]}]},{"name":"National Institutes of Health","award":["R01GM104007"],"award-info":[{"award-number":["R01GM104007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In response to changing environments, the nematode Caenorhabditis elegans enters a stress-resistant diapause stage to survive adverse conditions. While the pathways controlling developmental arrest, such as insulin\/daf-2 and TGF-\u03b2\/daf-7, are well characterized, mechanisms governing subsequent dauer morphogenesis remain poorly understood. Here, we report that the zinc-finger transcription factor ZTF-30 is dispensable for developmental arrest but essential for dauer morphogenesis. ztf-30 mutants form partial dauers that lack a protective thickened cuticle and specialized structures such as alae. Transcriptomics revealed that ztf-30 mutants precociously activate adult collagen expression and upregulate the DBL-1\/BMP signaling pathway, which primarily modulates body size and innate immunity. These data suggest ZTF-30 represses BMP signaling. Consistent with this model, zt-f-30 partial dauers show increased dbl-1 expression, increased DBL-1 signaling phenocopies ztf-30 loss, and reducing DBL-1 signaling rescues the partial dauer phenotype. During larval growth, ztf-30 loss causes ectopic hypodermal dbl-1 expression and increased body length. Ultimately, our findings establish that the active inhibition of DBL-1\/BMP signaling is strictly required for proper dauer morphogenesis and we identify ZTF-30 as an essential transcriptional repressor driving this developmental shutdown.<\/jats:p>","DOI":"10.1242\/dev.205808","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:20:41Z","timestamp":1790767241000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>C. elegans<\/i>\n                    dauer morphogenesis requires inhibition of DBL-1\/BMP signaling by\n                    <i>ztf-30<\/i>"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1622-7106","authenticated-orcid":false,"given":"Luciana F.","family":"Godoy","sequence":"first","affiliation":[{"name":"Universidad Maimonides, Centro de Estudios Biom\u00e9dicos B\u00e1sicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides 1 , Hidalgo 775, Buenos Aires CABA (1405) ,","place":["Argentina"]},{"name":"Universidad de Buenos 2 Departamento de FBMC, FCEN , Aires Intendente, G\u00fciraldes 2160 (1428) CABA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1052-1844","authenticated-orcid":false,"given":"M. Eugenia","family":"P\u00e1ez","sequence":"additional","affiliation":[{"name":"Universidad Maimonides, Centro de Estudios Biom\u00e9dicos B\u00e1sicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides 1 , Hidalgo 775, Buenos Aires CABA (1405) ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0128-4054","authenticated-orcid":false,"given":"Nicol\u00e1s R.","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Universidad Maimonides, Centro de Estudios Biom\u00e9dicos B\u00e1sicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides 1 , Hidalgo 775, Buenos Aires CABA (1405) ,","place":["Argentina"]},{"name":"Universidad de Buenos 2 Departamento de FBMC, FCEN , Aires Intendente, G\u00fciraldes 2160 (1428) CABA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5053-3813","authenticated-orcid":false,"given":"Yvan","family":"Doctorovich","sequence":"additional","affiliation":[{"name":"Universidad Maimonides, Centro de Estudios Biom\u00e9dicos B\u00e1sicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimonides 1 , Hidalgo 775, Buenos Aires CABA (1405) ,","place":["Argentina"]},{"name":"Universidad de Buenos 2 Departamento de FBMC, FCEN , Aires Intendente, G\u00fciraldes 2160 (1428) CABA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6886-8787","authenticated-orcid":false,"given":"Judith L.","family":"Yanowitz","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Magee-Womens Research Institute 3 , 204 Craft Avenue, Pittsburgh, PA 15213 ,","place":["USA"]},{"name":"University of Pittsburgh School of Medicine 4 Department of Obstetrics, Gynecology and Reproductive Sciences , , Pittsburgh, PA 15213 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-7529","authenticated-orcid":false,"given":"Daniel","family":"Hochbaum","sequence":"additional","affiliation":[{"name":"Universidad Maim\u00f3nides: Universidad Maimonides 5 , Ciudad de Buenos Aires C1405BMA ,","place":["Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"2026093007203597600_DEV205808C1","doi-asserted-by":"publisher","first-page":"e3001204","DOI":"10.1371\/journal.pbio.3001204","article-title":"DAF-16\/FoxO and DAF-12\/VDR control cellular plasticity both cell-autonomously and via interorgan signaling","volume":"19","author":"Aghayeva","year":"2021","journal-title":"PLoS Biol."},{"key":"2026093007203597600_DEV205808C2","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0012-1606(88)90138-8","article-title":"Mutants of Caenorhabditis elegans that form dauer-like larvae","volume":"126","author":"Albert","year":"1988","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C3","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"2026093007203597600_DEV205808C4","doi-asserted-by":"publisher","first-page":"10.1002\/wdev.278","DOI":"10.1002\/wdev.278","article-title":"Phenotypic plasticity and remodeling in the stress-induced Caenorhabditis elegans dauer","volume":"6","author":"Androwski","year":"2017","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"2026093007203597600_DEV205808C5","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1242\/dev.125.7.1191","article-title":"daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans","volume":"125","author":"Antebi","year":"1998","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C6","doi-asserted-by":"publisher","first-page":"RP106183","DOI":"10.7554\/eLife.106183.1","article-title":"Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons","volume":"14","author":"Barrett","year":"2025","journal-title":"eLife"},{"key":"2026093007203597600_DEV205808C7","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat. Methods"},{"key":"2026093007203597600_DEV205808C8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1164899","article-title":"Nuclear hormone receptor regulation of microRNAs controls developmental progression","volume":"324","author":"Bethke","year":"2009","journal-title":"Science"},{"key":"2026093007203597600_DEV205808C9","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0012-1606(75)90109-8","article-title":"The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans","volume":"46","author":"Cassada","year":"1975","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C10","doi-asserted-by":"publisher","first-page":"e1009836","DOI":"10.1371\/journal.pgen.1009836","article-title":"BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans","volume":"17","author":"Clark","year":"2021","journal-title":"PLoS Genet."},{"key":"2026093007203597600_DEV205808C11","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1534\/genetics.116.191858","article-title":"Developmental and cell cycle quiescence is mediated by the nuclear hormone receptor coregulator DIN-1S in the Caenorhabditis elegans dauer larva","volume":"203","author":"Colella","year":"2016","journal-title":"Genetics"},{"key":"2026093007203597600_DEV205808C12","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1242\/dev.060905","article-title":"Specific insulin-like peptides encode sensory information to regulate distinct developmental processes","volume":"138","author":"Cornils","year":"2011","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C13","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/0012-1606(81)90204-9","article-title":"The cuticle of Caenorhabditis elegans. II. Stage-specific changes in ultrastructure and protein composition during postembryonic development","volume":"86","author":"Cox","year":"1981","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1242\/dev.00922","article-title":"DAF-5 is a SKi oncoprotein homolog that functions in a neuronal TGF\u03b2 pathway to regulate C. elegans dauer development","volume":"131","author":"da Graca","year":"2004","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C15","doi-asserted-by":"publisher","first-page":"giab008","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"GigaScience"},{"key":"2026093007203597600_DEV205808C16","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.12688\/f1000research.21142.2","article-title":"Falco: High-speed FastQC emulation for quality control of sequencing data","volume":"8","author":"de Sena Brandine","year":"2021","journal-title":"F1000Res."},{"key":"2026093007203597600_DEV205808C17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026093007203597600_DEV205808C18","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1101\/gad.1701508","article-title":"C. elegans dauer formation and the molecular basis of plasticity","volume":"22","author":"Fielenbach","year":"2008","journal-title":"Genes Dev."},{"key":"2026093007203597600_DEV205808C19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ydbio.2007.08.016","article-title":"crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans","volume":"311","author":"Fung","year":"2007","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C20","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1242\/dev.01068","article-title":"Hormonal signals produced by DAF-9\/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues","volume":"131","author":"Gerisch","year":"2004","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C21","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1080\/21541264.2023.2190295","article-title":"Transcriptional and spatiotemporal regulation of the dauer program","volume":"14","author":"Godoy","year":"2023","journal-title":"Transcription"},{"key":"2026093007203597600_DEV205808C22","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/0012-1606(84)90201-X","article-title":"The Caenorhabditis elegans dauer larva: Developmental effects of pheromone, food, and temperature","volume":"102","author":"Golden","year":"1984","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C23","doi-asserted-by":"publisher","first-page":"18668","DOI":"10.1073\/pnas.0908131106","article-title":"A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans","volume":"106","author":"Hammell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026093007203597600_DEV205808C24","doi-asserted-by":"publisher","first-page":"100276","DOI":"10.1016\/j.xpro.2020.100276","article-title":"Liquid-culture protocols for synchronous starvation, growth, dauer formation, and dietary restriction of Caenorhabditis elegans","volume":"2","author":"Hibshman","year":"2021","journal-title":"STAR Protoc."},{"key":"2026093007203597600_DEV205808C25","doi-asserted-by":"publisher","first-page":"e1002179","DOI":"10.1371\/journal.pgen.1002179","article-title":"DAF-12 regulates a connected network of genes to ensure robust developmental decisions","volume":"7","author":"Hochbaum","year":"2011","journal-title":"PLoS Genet."},{"key":"2026093007203597600_DEV205808C26","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0531-5565(02)00063-3","article-title":"Ageing is reversed, and metabolism is reset to young levels in recovering dauer larvae of C. elegans","volume":"37","author":"Houthoofd","year":"2002","journal-title":"Exp. Gerontol."},{"key":"2026093007203597600_DEV205808C27","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1242\/dev.103846","article-title":"A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication","volume":"141","author":"Hung","year":"2014","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C28","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1006\/dbio.1999.9545","article-title":"Targets of TGF-\u03b2 signaling in Caenorhabditis elegans dauer formation","volume":"217","author":"Inoue","year":"2000","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C29","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1534\/g3.113.009522","article-title":"Use of an activated beta-catenin to identify Wnt pathway target genes in Caenorhabditis elegans, including a subset of collagen genes expressed in late larval development","volume":"4","author":"Jackson","year":"2014","journal-title":"G3"},{"key":"2026093007203597600_DEV205808C30","doi-asserted-by":"publisher","first-page":"e2109508119","DOI":"10.1073\/pnas.2109508119","article-title":"The CHARGE syndrome ortholog CHD-7 regulates TGF-\u03b2 pathways in Caenorhabditis elegans","volume":"119","author":"Jofr\u00e9","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026093007203597600_DEV205808C31","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s43556-026-00436-1","article-title":"The extracellular matrix: structure, composition, biological functions, diseases, and therapeutic targets","volume":"7","author":"Kamal","year":"2026","journal-title":"Mol. Biomed."},{"key":"2026093007203597600_DEV205808C32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome-wide RNAi screening in Caenorhabditis elegans","volume":"30","author":"Kamath","year":"2003","journal-title":"Methods"},{"key":"2026093007203597600_DEV205808C33","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans","volume":"277","author":"Kimura","year":"1997","journal-title":"Science"},{"key":"2026093007203597600_DEV205808C34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1242\/dev.126.2.251","article-title":"Specificity of TGF\u03b2 signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans","volume":"126","author":"Krishna","year":"1999","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C35","doi-asserted-by":"publisher","first-page":"W183","DOI":"10.1093\/nar\/gkz347","article-title":"modEnrichr: a suite of gene set enrichment analysis tools for model organisms","volume":"47","author":"Kuleshov","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2026093007203597600_DEV205808C36","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/S0960-9822(00)00833-2","article-title":"Caenorhabditis elegans is a model host for Salmonella typhimurium","volume":"10","author":"Labrousse","year":"2000","journal-title":"Curr. Biol."},{"key":"2026093007203597600_DEV205808C37","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1091\/mbc.E19-09-0500","article-title":"Genetic interactions between the DBL-1\/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans","volume":"30","author":"Lakdawala","year":"2019","journal-title":"Mol. Biol. Cell"},{"key":"2026093007203597600_DEV205808C38","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"2026093007203597600_DEV205808C39","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1016\/S0960-9822(01)00595-4","article-title":"Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway","volume":"11","author":"Lee","year":"2001","journal-title":"Curr. Biol."},{"key":"2026093007203597600_DEV205808C40","doi-asserted-by":"publisher","first-page":"E10726","DOI":"10.1073\/pnas.1710374114","article-title":"FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system","volume":"114","author":"Lee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026093007203597600_DEV205808C41","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.ydbio.2007.02.038","article-title":"Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs","volume":"305","author":"Liang","year":"2007","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C42","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2026093007203597600_DEV205808C43","doi-asserted-by":"publisher","first-page":"iyad097","DOI":"10.1093\/genetics\/iyad097","article-title":"daf-42 is an evolutionarily young gene essential for dauer development in Caenorhabditis elegans","volume":"224","author":"Lim","year":"2023","journal-title":"Genetics"},{"key":"2026093007203597600_DEV205808C44","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin\/IGF-1 and germline signaling","volume":"28","author":"Lin","year":"2001","journal-title":"Nat. Genet."},{"key":"2026093007203597600_DEV205808C45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-213X-4-11","article-title":"Regulation of signaling genes by TGF\u03b2 during entry into dauer diapause in C. elegans","volume":"4","author":"Liu","year":"2004","journal-title":"BMC Dev. Biol."},{"key":"2026093007203597600_DEV205808C46","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"2026093007203597600_DEV205808C47","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1101\/gad.312604","article-title":"A novel nuclear receptor\/coregulator complex controls C. elegans lipid metabolism, larval development, and aging","volume":"18","author":"Ludewig","year":"2004","journal-title":"Genes Dev."},{"key":"2026093007203597600_DEV205808C48","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1534\/genetics.118.301631","article-title":"BMP signaling determines body size via transcriptional regulation of collagen genes in Caenorhabditis elegans","volume":"210","author":"Madaan","year":"2018","journal-title":"Genetics"},{"key":"2026093007203597600_DEV205808C49","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1091\/mbc.E19-07-0390","article-title":"Feedback regulation of BMP signaling by Caenorhabditis elegans cuticle collagens","volume":"31","author":"Madaan","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"2026093007203597600_DEV205808C50","doi-asserted-by":"publisher","first-page":"e75831","DOI":"10.7554\/eLife.75831","article-title":"The DBL-1\/TGF-\u03b2 signaling pathway tailors behavioral and molecular host responses to a variety of bacteria in Caenorhabditis elegans","volume":"12","author":"Madhu","year":"2023","journal-title":"eLife"},{"key":"2026093007203597600_DEV205808C51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1471-213X-5-8","article-title":"C. elegans serine-threonine kinase KIN-29 modulates TGF\u03b2 signaling and regulates body size formation","volume":"5","author":"Maduzia","year":"2005","journal-title":"BMC Dev. Biol."},{"key":"2026093007203597600_DEV205808C52","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1242\/dev.01069","article-title":"Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450","volume":"131","author":"Mak","year":"2004","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C53","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet. J."},{"key":"2026093007203597600_DEV205808C54","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1126\/science.1087782","article-title":"Autophagy genes are essential for dauer development and life-span extension in C. elegans","volume":"301","author":"Mel\u00e9ndez","year":"2003","journal-title":"Science"},{"key":"2026093007203597600_DEV205808C55","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1242\/dev.126.6.1337","article-title":"Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-\u03b2 family","volume":"126","author":"Morita","year":"1999","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C56","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.cell.2006.01.037","article-title":"Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans","volume":"124","author":"Motola","year":"2006","journal-title":"Cell"},{"key":"2026093007203597600_DEV205808C57","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1242\/dev.02232","article-title":"Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling","volume":"133","author":"Narbonne","year":"2006","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C58","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1534\/g3.116.030163","article-title":"Fluorescent beads are a Versatile tool for staging Caenorhabditis elegans in different life histories","volume":"6","author":"Nika","year":"2016","journal-title":"G3"},{"key":"2026093007203597600_DEV205808C59","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/40194","article-title":"The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans","volume":"389","author":"Ogg","year":"1997","journal-title":"Nature"},{"key":"2026093007203597600_DEV205808C60","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/bioinformatics\/btv566","article-title":"Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data","volume":"32","author":"Okonechnikov","year":"2016","journal-title":"Bioinformatics"},{"key":"2026093007203597600_DEV205808C61","doi-asserted-by":"publisher","first-page":"ENEURO.0473-20.2021","DOI":"10.1523\/ENEURO.0473-20.2021","article-title":"Dauer formation in C. elegans is modulated through AWC and ASI-dependent chemosensation","volume":"8","author":"Pandey","year":"2021","journal-title":"ENeuro"},{"key":"2026093007203597600_DEV205808C62","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1242\/dev.043752","article-title":"Antagonistic Smad transcription factors control the dauer\/non-dauer switch in C. elegans","volume":"137","author":"Park","year":"2010","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C63","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1101\/gad.11.20.2679","article-title":"The DAF-3 Smad protein antagonizes TGF-\u03b2-related receptor signaling in the Caenorhabditis elegans dauer pathway","volume":"11","author":"Patterson","year":"1997","journal-title":"Genes Dev."},{"key":"2026093007203597600_DEV205808C64","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12915-020-0760-3","article-title":"A metabolic switch regulates the transition between growth and diapause in C. elegans","volume":"18","author":"Penkov","year":"2020","journal-title":"BMC Biol."},{"key":"2026093007203597600_DEV205808C65","doi-asserted-by":"publisher","first-page":"3986","DOI":"10.1016\/j.cub.2025.05.028","article-title":"Insulin signaling activity in the somatic gonad controls dauer entry via the germ line in C. elegans","volume":"35","author":"Przybyl","year":"2025","journal-title":"Curr. Biol."},{"key":"2026093007203597600_DEV205808C90","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/J.YDBIO.2014.03.015","article-title":"CEH-28 activates dbl-1 expression and TGF-\u03b2 signaling in the C. elegans M4 neuron","volume":"390","author":"Ramakrishnan","year":"2014","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C66","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1126\/science.274.5291.1389","article-title":"Control of C. elegans larval development by neuronal expression of a TGF-\u03b2 homolog","volume":"274","author":"Ren","year":"1996","journal-title":"Science"},{"key":"2026093007203597600_DEV205808C67","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1471-213X-10-61","article-title":"Regulation of genes affecting body size and innate immunity by the DBL-1\/BMP-like pathway in Caenorhabditis elegans","volume":"10","author":"Roberts","year":"2010","journal-title":"BMC Dev. Biol."},{"key":"2026093007203597600_DEV205808C68","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1073\/pnas.93.2.790","article-title":"Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of Transforming Growth Factor \u03b2 pathway components","volume":"93","author":"Savage","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026093007203597600_DEV205808C69","doi-asserted-by":"publisher","first-page":"a022178","DOI":"10.1101\/cshperspect.a022178","article-title":"The TGF-\u03b2 family in Caenorhabditis elegans","volume":"9","author":"Savage-Dunn","year":"2017","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"2026093007203597600_DEV205808C70","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1017\/S0016672311000310","article-title":"Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans","volume":"93","author":"Savage-Dunn","year":"2011","journal-title":"Genet. Res."},{"key":"2026093007203597600_DEV205808C71","doi-asserted-by":"publisher","first-page":"e1001306","DOI":"10.1371\/journal.pbio.1001306","article-title":"Hormonal signal amplification mediates environmental conditions during development and controls an irreversible commitment to adulthood","volume":"10","author":"Schaedel","year":"2012","journal-title":"PLoS Biol."},{"key":"2026093007203597600_DEV205808C72","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"2026093007203597600_DEV205808C73","doi-asserted-by":"publisher","first-page":"e51834","DOI":"10.3791\/51834-v","article-title":"In vivo imaging of Dauer-specific neuronal remodeling in C. elegans","volume":"91","author":"Schroeder","year":"2014","journal-title":"J. Vis. Exp."},{"key":"2026093007203597600_DEV205808C74","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.cub.2013.06.058","article-title":"Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1\/furin","volume":"23","author":"Schroeder","year":"2013","journal-title":"Curr. Biol."},{"key":"2026093007203597600_DEV205808C75","doi-asserted-by":"publisher","first-page":"e101929","DOI":"10.1371\/journal.pone.0101929","article-title":"Regulation of extracellular matrix organization by BMP signaling in Caenorhabditis elegans","volume":"9","author":"Schultz","year":"2014","journal-title":"PLoS ONE"},{"key":"2026093007203597600_DEV205808C76","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ydbio.2019.06.009","article-title":"Genetic markers enable the verification and manipulation of the dauer entry decision","volume":"454","author":"Shih","year":"2019","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C77","doi-asserted-by":"publisher","first-page":"iyae072","DOI":"10.1093\/genetics\/iyae072","article-title":"The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo","volume":"227","author":"Sundaram","year":"2024","journal-title":"Genetics"},{"key":"2026093007203597600_DEV205808C78","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1242\/dev.126.2.241","article-title":"A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans","volume":"126","author":"Suzuki","year":"1999","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C79","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s12915-022-01252-z","article-title":"Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways","volume":"20","author":"Szil\u00e1gyi","year":"2022","journal-title":"BMC Biol."},{"key":"2026093007203597600_DEV205808C80","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/j.cub.2019.01.076","article-title":"Cell non-autonomous function of daf-18\/PTEN in the somatic gonad coordinates somatic gonad and germline development in C. elegans dauer larvae","volume":"29","author":"Tenen","year":"2019","journal-title":"Curr. Biol."},{"key":"2026093007203597600_DEV205808C81","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s13071-021-04953-6","article-title":"On the role of dauer in the adaptation of nematodes to a parasitic lifestyle","volume":"14","author":"Vlaar","year":"2021","journal-title":"Parasites Vectors"},{"key":"2026093007203597600_DEV205808C82","doi-asserted-by":"publisher","first-page":"RP99394","DOI":"10.7554\/eLife.99394.3","article-title":"Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion","volume":"13","author":"Vora","year":"2025","journal-title":"eLife"},{"key":"2026093007203597600_DEV205808C83","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1093\/genetics\/130.1.105","article-title":"Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans","volume":"130","author":"Vowels","year":"1992","journal-title":"Genetics"},{"key":"2026093007203597600_DEV205808C84","doi-asserted-by":"publisher","first-page":"4989","DOI":"10.1242\/dev.129.21.4989","article-title":"The expression of TGF\u03b2 signal transducers in the hypodermis regulates body size in C. elegans","volume":"129","author":"Wang","year":"2002","journal-title":"Development"},{"key":"2026093007203597600_DEV205808C85","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1074\/jbc.M117.798553","article-title":"The biotin-ligating protein BPL-1 is critical for lipid biosynthesis and polarization of the Caenorhabditis elegans embryo","volume":"293","author":"Watts","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2026093007203597600_DEV205808C86","doi-asserted-by":"publisher","first-page":"e1009881","DOI":"10.1371\/journal.pgen.1009881","article-title":"Daf-16\/FOXO blocks adult cell fate in Caenorhabditis elegans dauer larvae via lin-41\/TRIM71","volume":"17","author":"Wirick","year":"2021","journal-title":"PLoS Genet."},{"key":"2026093007203597600_DEV205808C87","doi-asserted-by":"publisher","DOI":"10.3908\/wormatlas.3.1","article-title":"The Dauer Cuticle","volume-title":"WormAtlas","author":"Wolkow","year":"2011"},{"key":"2026093007203597600_DEV205808C88","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1006\/dbio.2001.0443","article-title":"Hypodermal Expression of Caenorhabditis elegans TGF-\u03b2 Type I Receptor SMA-6 Is Essential for the Growth and Maintenance of Body Length","volume":"240","author":"Yoshida","year":"2001","journal-title":"Dev. Biol."},{"key":"2026093007203597600_DEV205808C89","doi-asserted-by":"publisher","first-page":"17081","DOI":"10.1073\/pnas.1205982109","article-title":"DBL-1, a TGF-\u03b2, is essential for Caenorhabditis elegans aversive olfactory learning","volume":"109","author":"Zhang","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026093007203597600_DEV205808C91","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/ni.1700","article-title":"Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-\u03b2 signaling pathway in Caenorhabditis elegans epidermis","volume":"10","author":"Zugasti","year":"2009","journal-title":"Nat. Immunol"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205808\/3719735\/dev205808.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.205808\/3719735\/dev205808.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:20:43Z","timestamp":1790767243000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/19\/dev205808\/373048\/C-elegans-dauer-morphogenesis-requires-inhibition"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":91,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.205808","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"article-number":"dev205808"}}