{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:04:01Z","timestamp":1789639441693,"version":"4.0.0"},"reference-count":18,"publisher":"The Company of Biologists","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:p>This article discusses the preprinted work of Gr\u00e4\u00dflin et al. (2026 preprint). As a preprint, this work has not yet undergone peer review.<\/jats:p>","DOI":"10.1242\/dev.206041","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:22:53Z","timestamp":1789636973000},"source":"Crossref","is-referenced-by-count":0,"title":["In preprints \u2013 \u2018slow and steady\u2019 versus \u2018fast and ready\u2019 (re)generation of insulin-expressing cells in zebrafish"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6715-781X","authenticated-orcid":false,"given":"Olov","family":"Andersson","sequence":"first","affiliation":[{"name":"Uppsala University 1 Department of Medical Cell Biology , , BMC, Husargatan 3, 75123 Uppsala ,","place":["Sweden"]},{"name":"Science for Life Laboratory, Uppsala University 2 , BMC, Husargatan 3, 75123 Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Mi","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine 3 Department of Gastroenterology, Sir Run Run Shaw Hospital , , 310016, Hangzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Ma","sequence":"additional","affiliation":[{"name":"Uppsala University 1 Department of Medical Cell Biology , , BMC, Husargatan 3, 75123 Uppsala ,","place":["Sweden"]},{"name":"Science for Life Laboratory, Uppsala University 2 , BMC, Husargatan 3, 75123 Uppsala ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"2026091705224704100_DEV206041C1","doi-asserted-by":"publisher","first-page":"e67576","DOI":"10.7554\/eLife.67576","article-title":"A \u03b4-cell subpopulation with a pro-\u03b2-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes","volume":"11","author":"Carril Pardo","year":"2022","journal-title":"eLife"},{"key":"2026091705224704100_DEV206041C2","doi-asserted-by":"publisher","first-page":"3499","DOI":"10.2337\/db15-0153","article-title":"Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration","volume":"64","author":"Delaspre","year":"2015","journal-title":"Diabetes"},{"key":"2026091705224704100_DEV206041C3","doi-asserted-by":"publisher","DOI":"10.1038\/s41536-026-00482-x","article-title":"Comparison of cardiac regeneration capacity between zebrafish and medaka reveals a regenerative response in both teleost species","author":"Garitagoitia-Romero","year":"2026","journal-title":"NPJ Regen. Med."},{"key":"2026091705224704100_DEV206041C4","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s12915-015-0179-4","article-title":"Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration","volume":"13","author":"Ghaye","year":"2015","journal-title":"BMC Biol."},{"key":"2026091705224704100_DEV206041C5","doi-asserted-by":"publisher","DOI":"10.64898\/2026.05.24.727280","article-title":"Pre-existing chromatin accessibility primes \u03b4-cells for injury-induced endocrine plasticity","author":"Gr\u00e4\u00dflin","year":"2026","journal-title":"bioRxiv"},{"key":"2026091705224704100_DEV206041C6","doi-asserted-by":"publisher","first-page":"3362","DOI":"10.1038\/s41467-021-23673-0","article-title":"Reinforcing one-carbon metabolism via folic acid\/Folr1 promotes beta-cell differentiation","volume":"12","author":"Karampelias","year":"2021","journal-title":"Nat. Commun."},{"key":"2026091705224704100_DEV206041C7","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41589-024-01822-y","article-title":"Mechanistic insights and approaches for beta cell regeneration","volume":"21","author":"Karampelias","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"2026091705224704100_DEV206041C18","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.2337\/db11-1841","article-title":"Nutrient excess stimulates \u03b2-cell neogenesis in zebrafish","volume":"61","author":"Maddison","year":"2012","journal-title":"Diabetes"},{"key":"2026091705224704100_DEV206041C8","doi-asserted-by":"publisher","first-page":"eadf5142","DOI":"10.1126\/sciadv.adf5142","article-title":"Decoding pancreatic endocrine cell differentiation and beta cell regeneration in zebrafish","volume":"9","author":"Mi","year":"2023","journal-title":"Sci. Adv."},{"key":"2026091705224704100_DEV206041C9","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.2337\/db08-0628","article-title":"Regeneration of the pancreas in adult zebrafish","volume":"58","author":"Moss","year":"2009","journal-title":"Diabetes"},{"key":"2026091705224704100_DEV206041C10","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.cub.2013.05.037","article-title":"Metabolic regulation of cellular plasticity in the pancreas","volume":"23","author":"Ninov","year":"2013","journal-title":"Curr. Biol."},{"key":"2026091705224704100_DEV206041C11","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1158\/2159-8290.CD-20-1637","article-title":"Cancer cells retrace a stepwise differentiation program during malignant progression","volume":"11","author":"Saghafinia","year":"2021","journal-title":"Cancer Discov."},{"key":"2026091705224704100_DEV206041C12","doi-asserted-by":"publisher","first-page":"dev199853","DOI":"10.1242\/dev.199853","article-title":"A single-cell atlas of de novo \u03b2-cell regeneration reveals the contribution of hybrid \u03b2\/\u03b4-cells to diabetes recovery in zebrafish","volume":"149","author":"Singh","year":"2022","journal-title":"Development"},{"key":"2026091705224704100_DEV206041C13","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1128\/MCB.18.9.5109","article-title":"An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)","volume":"18","author":"Swift","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2026091705224704100_DEV206041C14","doi-asserted-by":"publisher","first-page":"e12311","DOI":"10.1371\/journal.pone.0012311","article-title":"The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding","volume":"5","author":"von Burstin","year":"2010","journal-title":"PLoS ONE"},{"key":"2026091705224704100_DEV206041C15","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.molmet.2018.01.011","article-title":"Genome-wide analysis of PDX1 target genes in human pancreatic progenitors","volume":"9","author":"Wang","year":"2018","journal-title":"Mol. Metab."},{"key":"2026091705224704100_DEV206041C16","doi-asserted-by":"publisher","first-page":"9355","DOI":"10.1038\/s41467-025-64774-4","article-title":"A multimodal cross-species comparison of pancreas development","volume":"16","author":"Yang","year":"2025","journal-title":"Nat. Commun."},{"key":"2026091705224704100_DEV206041C17","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.ydbio.2006.06.030","article-title":"Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development","volume":"300","author":"Zhang","year":"2006","journal-title":"Dev. Biol."}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.206041\/3718001\/dev206041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/doi\/10.1242\/dev.206041\/3718001\/dev206041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:22:53Z","timestamp":1789636973000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/153\/18\/dev206041\/372925\/In-preprints-slow-and-steady-versus-fast-and-ready"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":18,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,15]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.206041","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"article-number":"dev206041"}}