{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:45:44Z","timestamp":1792147544331,"version":"4.4.0"},"reference-count":63,"publisher":"The Company of Biologists","issue":"20","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-2\/"}],"funder":[{"name":"National Institutes of Health"},{"name":"National Institute of Child Health and Human Development","award":["P01HD084387"],"award-info":[{"award-number":["P01HD084387"]}]},{"name":"National Institutes of Health"},{"name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["NIAMS: R01AR072009"],"award-info":[{"award-number":["NIAMS: R01AR072009"]}],"id":[{"id":"https:\/\/ror.org\/006zn3t30","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Motile cilia generate fluid flows that are essential for normal development and physiology. Cilia display diverse beating waveforms, and while pronounced defects are strongly associated with motile ciliopathies, subtler alterations also influence disease manifestations. Finer quantification of ciliary dynamics is therefore crucial for understanding ciliopathies, but the heterogeneity of cilia beating makes accurate and robust characterization challenging. Here, we present CiliaIO, a machine learning-based tool for quantification of motile cilia morphodynamics. Using this platform, we discovered subtle but highly significant regional differences in ciliary waveforms in the zebrafish spinal cord. To demonstrate the efficacy of the tool, we used CiliaIO to capture and quantify subtle ciliary defects in a previously unreported bbs2 allele that causes a late-onset scoliosis phenotype. These results provide a workflow for additional fine-scale analyses of ciliary morphodynamics that will be important for understanding motile ciliopathy.<\/jats:p>","DOI":"10.1242\/dev.206057","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:20:56Z","timestamp":1789719656000},"source":"Crossref","is-referenced-by-count":0,"title":["CiliaIO: machine learning reveals spatial patterns of cilia beating dynamics in the zebrafish spinal cord"],"prefix":"10.1242","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0687-2501","authenticated-orcid":false,"given":"Ece","family":"Atayeter","sequence":"first","affiliation":[{"name":"The University of Texas at Austin 1 Department of Molecular Biosciences , , Austin, TX 78712 ,","place":["USA"]},{"name":"Dell Pediatric Research Institute, The University of Texas at Austin 2 Department of Nutrition and Pediatrics , , Austin, TX 78723 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-2953","authenticated-orcid":false,"given":"Jason","family":"Ho","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin 3 Chandra Family Department of Electrical and Computer Engineering , , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3337-4751","authenticated-orcid":false,"given":"Talon G.","family":"Blottin","sequence":"additional","affiliation":[{"name":"Dell Pediatric Research Institute, The University of Texas at Austin 2 Department of Nutrition and Pediatrics , , Austin, TX 78723 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1161-4583","authenticated-orcid":false,"given":"Ilyena B.","family":"Joe","sequence":"additional","affiliation":[{"name":"Dell Pediatric Research Institute, The University of Texas at Austin 2 Department of Nutrition and Pediatrics , , Austin, TX 78723 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0796-9465","authenticated-orcid":false,"given":"Ron","family":"Sistrunk","sequence":"additional","affiliation":[{"name":"Dell Pediatric Research Institute, The University of Texas at Austin 2 Department of Nutrition and Pediatrics , , Austin, TX 78723 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-5314","authenticated-orcid":false,"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 4 Department of Developmental Biology , , South Euclid Avenue, St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0983-221X","authenticated-orcid":false,"given":"Lilianna","family":"Solnica-Krezel","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine 4 Department of Developmental Biology , , South Euclid Avenue, St Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6748-2054","authenticated-orcid":false,"given":"Andreas","family":"Gerstlauer","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin 3 Chandra Family Department of Electrical and Computer Engineering , , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Wallingford","sequence":"additional","affiliation":[{"name":"The University of Texas at Austin 1 Department of Molecular Biosciences , , Austin, TX 78712 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-6497","authenticated-orcid":false,"given":"Ryan S.","family":"Gray","sequence":"additional","affiliation":[{"name":"Dell Pediatric Research Institute, The University of Texas at Austin 2 Department of Nutrition and Pediatrics , , Austin, TX 78723 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"2026101605560636500_DEV206057C1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1126\/science.1084576","article-title":"A human syndrome caused by immotile cilia","volume":"193","author":"Afzelius","year":"1976","journal-title":"Science"},{"key":"2026101605560636500_DEV206057C2","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41592-025-02981-z","article-title":"Scikit-bio: a fundamental Python library for biological omic data analysis","volume":"23","author":"Aton","year":"2026","journal-title":"Nat. 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