{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T16:48:26Z","timestamp":1776012506506,"version":"3.50.1"},"reference-count":7,"publisher":"The Company of Biologists","issue":"1","license":[{"start":{"date-parts":[[1987,1,1]],"date-time":"1987-01-01T00:00:00Z","timestamp":536457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.biologists.com\/user-licence-1-1\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Administration of 2-methoxyethanol to pregnant rats on day 12 of gestation induced ventral duplication of the autopod, presumably via its oxidative metabolite, methoxyacetic acid. Morphological observations indicate that the limb bud periderm is severely damaged by methoxyacetic acid so that large patches of this structure are actually missing during an extended period of limb bud development. A high concentration of methoxyacetic acid (10 mM) was found in the extra-embryonic fluid and we postulate that the damage to the periderm was initiated from this extraembryonic exposure. The ventral duplication of the autopod is thought to arise through an attempt by the embryo to repair the periderm lesion.<\/jats:p>","DOI":"10.1242\/dev.99.1.127","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T14:27:21Z","timestamp":1619447241000},"page":"127-136","source":"Crossref","is-referenced-by-count":20,"title":["Ventral duplication of the autopod: chemical induction by methoxyacetic acid in rat embryos"],"prefix":"10.1242","volume":"99","author":[{"suffix":"Jr","given":"William J.","family":"Scott","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Research Foundation, Elland and Bethesda Aves, Cincinnati, OH 45229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nau","sequence":"additional","affiliation":[{"name":"Freie Universit\u00e4t Berlin Institut f\u00fcr Toxikologie und Embryonalpharmakologie , , Garystrasse 5, D-1000 Berlin 33, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wittfoht","sequence":"additional","affiliation":[{"name":"Freie Universit\u00e4t Berlin Institut f\u00fcr Toxikologie und Embryonalpharmakologie , , Garystrasse 5, D-1000 Berlin 33, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.-J.","family":"Merker","sequence":"additional","affiliation":[{"name":"Freie Universit\u00e4t Berlin Institut f\u00fcr Toxikologie und Embryonalpharmakologie , , Garystrasse 5, D-1000 Berlin 33, FRG"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/0378-4274(84)90051-1","article-title":"The teratogenicity of methoxyacetic acid in the rat","volume":"22","author":"Brown","year":"1984","journal-title":"Toxicol. Lett"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/0012-1606(86)90049-7","article-title":"Experimental manipulation leading to induction of dorsal ectodermal ridges on normal limb buds results in a phenocopy of the Eudiplopodia chick mutant","volume":"116","author":"Carrington","year":"1986","journal-title":"Devi Biol"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/jez.1401760209","article-title":"Studies on limb morphogenesis: VI. Experiments with early stages of the polydactylous mutant Eudiplopodia","volume":"176","author":"Fraser","year":"1971","journal-title":"J. exp. Zool"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0012-1606(64)90005-3","article-title":"Studies on limb morphogenesis. II. Experiments with the polydactylous mutant Eudiplopodia","volume":"10","author":"Goetinck","year":"1964","journal-title":"Devl Biol"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/BF00305153","article-title":"An electron microscopic study of periderm cell development in mouse limb buds","volume":"157","author":"Nakamura","year":"1979","journal-title":"Anat. Embryol"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/tera.1420320105","article-title":"Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat","volume":"32","author":"Ritter","year":"1985","journal-title":"Teratology"},{"key":"2023040616365110200_","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0378-4274(84)90229-7","article-title":"Effects of dimethoxyethyl phthalate, monomethoxyethyl phthalate, 2-methoxyethanol and methoxyacetic acid on postimplantation rat embryos in cultures","volume":"21","author":"Yonemoto","year":"1984","journal-title":"Toxicol. Lett"}],"container-title":["Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/99\/1\/127\/2783097\/develop_99_1_127.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.biologists.com\/dev\/article-pdf\/99\/1\/127\/2783097\/develop_99_1_127.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T16:36:58Z","timestamp":1680799018000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.biologists.com\/dev\/article\/99\/1\/127\/51703\/Ventral-duplication-of-the-autopod-chemical"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1,1]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1,1]]}},"URL":"https:\/\/doi.org\/10.1242\/dev.99.1.127","relation":{},"ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1,1]]}}}