{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:56:48Z","timestamp":1765040208209},"reference-count":46,"publisher":"The Company of Biologists","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:p>The incidence of oesophageal adenocarcinoma has increased dramatically in the Western world over the past two decades. Owing to its dismal 5-year prognosis in advanced stages, early diagnosis is required in order to improve survival rates. Barrett\u2019s oesophagus (Barrett\u2019s) has been recognised as a pre-cancerous condition generally associated with chronic and severe gastro-oesophageal reflux disease (GORD). Barrett\u2019s is defined as the substitution of the normal stratified squamous epithelium of the oesophagus with a columnar cell lining with intestinal-type differentiation; a phenomenon commonly referred to as intestinal metaplasia. Clinical challenges include finding cost-effective ways to identify patients with Barrett\u2019s, stratifying them according to their cancer risk and improving the diagnostic potential of endoscopic sampling. Research has generally focused on identifying tissue biomarkers to predict cancer risk in these patients. The oesophagus is easily accessible, making it possible to work with human samples, but most studies have been retrospective and underpowered. Endoscopic surveillance programmes are problematic due to sampling bias and the subjective grading of dysplasia. The lack of an animal model has hampered studies to elucidate markers of the transition from Barrett\u2019s to cancer and to test potential therapeutics. However, a number of in vitro model systems are ripe for further development into more physiologically complete systems.<\/jats:p>","DOI":"10.1242\/dmm.000273","type":"journal-article","created":{"date-parts":[[2008,8,4]],"date-time":"2008-08-04T20:29:08Z","timestamp":1217881748000},"page":"26-31","source":"Crossref","is-referenced-by-count":7,"title":["Clinical puzzle: Barrett\u2019s oesophagus"],"prefix":"10.1242","volume":"1","author":[{"given":"Massimiliano","family":"di Pietro","sequence":"first","affiliation":[{"name":"MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Peters","sequence":"additional","affiliation":[{"name":"MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge, CB2 0XZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042701322770100_b1-0010026","first-page":"457","article-title":"Increased expression of the cyclin D1 gene in Barrett\u2019s esophagus","volume":"5","author":"Arber","year":"1996","journal-title":"Cancer Epidemiol. 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