{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:59:22Z","timestamp":1791932362077,"version":"4.3.4"},"reference-count":59,"publisher":"The Company of Biologists","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,7]]},"abstract":"<jats:p>The filoviruses Ebola and Marburg are zoonotic agents that are classified as both biosafety level 4 and category A list pathogens. These viruses are pathogenic in humans and cause isolated infections or epidemics of viral hemorrhagic fever, mainly in Central Africa. Their natural reservoir has not been definitely identified, but certain species of African bat have been associated with Ebola and Marburg infections. Currently, there are no licensed options available for either treatment or prophylaxis. Different animal models have been developed for filoviruses including mouse, guinea pig and nonhuman primates. The \u2018gold standard\u2019 animal models for pathogenesis, treatment and vaccine studies are rhesus and cynomolgus macaques. This article provides a brief overview of the clinical picture and the pathology\/pathogenesis of human filovirus infections. The current animal model options are discussed and compared with regard to their value in different applications. In general, the small animal models, in particular the mouse, are the most feasible for high biocontainment facilities and they offer the most options for research owing to the greater availability of immunologic and genetic tools. However, their mimicry of the human diseases as well as their predictive value for therapeutic efficacy in primates is limited, thereby making them, at best, valuable initial screening tools for pathophysiology, treatment and vaccine studies.<\/jats:p>","DOI":"10.1242\/dmm.000471","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T18:58:23Z","timestamp":1231354703000},"page":"12-17","source":"Crossref","is-referenced-by-count":151,"title":["Disease modeling for Ebola and Marburg viruses"],"prefix":"10.1242","volume":"2","author":[{"given":"Dennis","family":"Bente","sequence":"first","affiliation":[{"name":"Special Pathogens Program, Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, R3E 3R2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gren","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, R3E 3R2 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Strong","sequence":"additional","affiliation":[{"name":"Special Pathogens Program, Laboratory for Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, R3E 3R2 Canada"},{"name":"Department of Medical Microbiology and"},{"name":"Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, R2H 2A6 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Feldmann","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and"},{"name":"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042500034635200_b1-0020012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1055\/s-0037-1616926","article-title":"Viral haemorrhagic fever and vascular alterations","volume":"28","author":"Aleksandrowicz","year":"2008","journal-title":"Hamostaseologie"},{"key":"2021042500034635200_b2-0020012","first-page":"270","article-title":"Development and study of the properties of immunoglobulin against Ebola fever","volume":"40","author":"Borisevich","year":"1995","journal-title":"Vopr. 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