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Emerging evidence that implicates the mRNA export factor GLE1 in two lethal motor neuron disorders is discussed and we highlight surprising links to regulatory mechanisms that were first observed many years ago in yeast. These examples illustrate how model organisms have aided in our elucidation of complex human disorders through analysis of basic cellular processes.<\/jats:p>","DOI":"10.1242\/dmm.000745","type":"journal-article","created":{"date-parts":[[2008,9,30]],"date-time":"2008-09-30T18:52:49Z","timestamp":1222800769000},"page":"103-108","source":"Crossref","is-referenced-by-count":42,"title":["mRNA nuclear export and human disease"],"prefix":"10.1242","volume":"1","author":[{"given":"Jessica A.","family":"Hurt","sequence":"first","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612425903400_b1-0010103","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbadis.2006.10.003","article-title":"Oculopharyngeal muscular dystrophy: recent advances in the understanding of the molecular pathogenic mechanisms and treatment strategies","volume":"1772","author":"Abu-Baker","year":"2007","journal-title":"Biochim. 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