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Neuroligin-deficient mutants of C. elegans are viable, and they do not appear deficient in any major motor functions. However, neuroligin mutants are defective in a subset of sensory behaviors and sensory processing, and are hypersensitive to oxidative stress and mercury compounds; the behavioral deficits are strikingly similar to traits frequently associated with autism spectrum disorders. Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders.<\/jats:p>","DOI":"10.1242\/dmm.003442","type":"journal-article","created":{"date-parts":[[2010,1,19]],"date-time":"2010-01-19T01:58:50Z","timestamp":1263866330000},"page":"366-376","source":"Crossref","is-referenced-by-count":87,"title":["Neuroligin-deficient mutants of<i>C. elegans<\/i>have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity"],"prefix":"10.1242","volume":"3","author":[{"given":"Jerrod W.","family":"Hunter","sequence":"first","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"},{"name":"Department of Cell Biology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Mullen","sequence":"additional","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"McManus","sequence":"additional","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Heatherly","sequence":"additional","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"},{"name":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie","family":"Duke","sequence":"additional","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Rand","sequence":"additional","affiliation":[{"name":"Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA"},{"name":"Department of Cell Biology and"},{"name":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042500172800300_b1-0030366","doi-asserted-by":"crossref","first-page":"B240","DOI":"10.1093\/gerona\/53A.4.B240","article-title":"Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans","volume":"53","author":"Adachi","year":"1998","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2021042500172800300_b2-0030366","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.freeradbiomed.2005.06.023","article-title":"High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein","volume":"39","author":"Alamdari","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"2021042500172800300_b3-0030366","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1126\/science.8342028","article-title":"The Caenorhabditis elegans unc-17 gene: A putative vesicular acetylcholine transporter","volume":"261","author":"Alfonso","year":"1993","journal-title":"Science"},{"key":"2021042500172800300_b4-0030366","unstructured":"Altun ZF , HallDH (2008). 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