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It has been speculated that this results from a functional overlap between individual MMPs and (as-yet-unclassified) functional overlaps between MMPs and other protease systems. We here present genetic data showing that concomitant ablation of MMP9 (gelatinase B) and the serine protease plasmin results in lethal inflammatory mass lesions in the colon. These lesions possessed several histological attributes that are characteristic of mucosal prolapse seen in humans, and they were found to be associated with splenomegaly, enlarged mesenteric lymph nodes, decreased thymus size and altered populations of circulating immune cells. A time-course study provided evidence that the massive lymphoid hyperplasia and reactive changes were secondary to discrete fibrinous lesions also observed in mice only deficient for plasminogen (Plg), the zymogen for plasmin. These data demonstrate a non-appreciated vital protective role for MMP9 in the absence of Plg.<\/jats:p>","DOI":"10.1242\/dmm.005801","type":"journal-article","created":{"date-parts":[[2010,12,2]],"date-time":"2010-12-02T05:50:50Z","timestamp":1291269050000},"page":"212-227","source":"Crossref","is-referenced-by-count":10,"title":["MMP9 is protective against lethal inflammatory mass lesions in the mouse colon"],"prefix":"10.1242","volume":"4","author":[{"given":"Andreas","family":"Hald","sequence":"first","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark"},{"name":"Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"R\u00f8n\u00f8","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark"},{"name":"Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Melander","sequence":"additional","affiliation":[{"name":"Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Ole Maal\u00f8es Vej 5, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Holck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hvidovre Hospital, Faculty of Health Sciences, University of Copenhagen, 2650 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leif R.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042612493891100_b1-0040212","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/modpathol.3880397","article-title":"Angiogenic polypoid proliferation adjacent to ileal carcinoid tumors: a nonspecific finding related to mucosal prolapse","volume":"14","author":"Abrahams","year":"2001","journal-title":"Mod. 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