{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:24:06Z","timestamp":1792139046856,"version":"4.4.0"},"reference-count":48,"publisher":"The Company of Biologists","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:p>Axon degeneration is observed in neurodegenerative diseases and neuroinflammatory disorders, such as Alzheimer\u2019s disease, Parkinson\u2019s disease and multiple sclerosis. The molecular basis of this process remains largely unknown. Here, we show that mice deleted for the tumour suppressor LKB1 (also called STK11) in the spinal cord, some parts of the brain and in the endocrine pancreas (\u03b2LKB1KO mice) develop hind-limb dysfunction and axon degeneration at about 7 weeks. Demyelination and macrophage infiltration are observed in the white matter of these mice, predominantly in the bilateral and anterior funiculi of the thoracic segment of the spinal cord, suggesting damage to the ascending sensory signalling pathway owing to LKB1 deletion in the brain. Microtubule structures were also affected in the degenerated foci, with diminished neurofilament and tubulin expression. Deletion of both PRKAA1 genes, whose products AMPK\u03b11 and AMPK\u03b12 are also downstream targets of LKB1, with the same strategy was without effect. We thus define LKB1 as an intrinsic suppressor of axon degeneration and a possible target for strategies that can reverse this process.<\/jats:p>","DOI":"10.1242\/dmm.006833","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T05:49:40Z","timestamp":1291700980000},"page":"193-202","source":"Crossref","is-referenced-by-count":28,"title":["<i>RIP2<\/i>-mediated <i>LKB1<\/i> deletion causes axon degeneration in the spinal cord and hind-limb paralysis"],"prefix":"10.1242","volume":"4","author":[{"given":"Gao","family":"Sun","sequence":"first","affiliation":[{"name":"Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Wolfson Neuroscience Laboratories, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Leclerc","sequence":"additional","affiliation":[{"name":"Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042612494818600_b1-0040193","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nrn2056","article-title":"Neuronal polarity: from extracellular signals to intracellular mechanisms","volume":"8","author":"Arimura","year":"2007","journal-title":"Nat. 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