{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:15:52Z","timestamp":1773659752706,"version":"3.50.1"},"reference-count":130,"publisher":"The Company of Biologists","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p>Diseases of intestinal inflammation, including Crohn\u2019s disease, ulcerative colitis and necrotizing enterocolitis, cause substantial acute and chronic disability in a large proportion of the population. Crohn\u2019s disease and ulcerative colitis, which are collectively referred to as inflammatory bowel disease (IBD), lead to recurrent episodes of intestinal dysfunction and systemic illness, whereas necrotizing enterocolitis is characterized by the development of dramatic and all too often fatal intestinal necrosis in infants. To determine the molecular underpinnings of these disorders, investigators have explored a variety of animal models that vary widely in their complexity. These experimental systems include the invertebrate nematode Caenorhabditis elegans, the more complex invertebrate Drosophila melanogaster, and vertebrate systems including mice, rats and other mammals. This review explores the experimental models that are used to mimic and evaluate the pathogenic mechanisms leading to these diseases of intestinal inflammation. We then highlight, as an example, how the use of different experimental models that focus on the role of Toll-like receptor 4 (TLR4) signaling in the gut has revealed important distinctions between the pathogenesis of IBD and necrotizing enterocolitis. Specifically, TLR4-mediated signaling plays a protective role in the development of Crohn\u2019s disease and ulcerative colitis, whereas this signaling pathway plays a causative role in the development of necrotizing enterocolitis in the newborn small intestine by adversely affecting intestinal injury and repair mechanisms.<\/jats:p>","DOI":"10.1242\/dmm.007252","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T00:49:57Z","timestamp":1308012597000},"page":"447-456","source":"Crossref","is-referenced-by-count":28,"title":["Worms, flies and four-legged friends: the applicability of biological models to the understanding of intestinal inflammatory diseases"],"prefix":"10.1242","volume":"4","author":[{"given":"Joyce","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery, Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA"},{"name":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Hackam","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Children\u2019s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA"},{"name":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","reference":[{"key":"2021042500184439100_b1-0040447","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/07853890008995906","article-title":"Medical significance of Caenorhabditis elegans","volume":"32","author":"Aboobaker","year":"2000","journal-title":"Ann. 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