{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:25:42Z","timestamp":1791023142094,"version":"4.1.0"},"reference-count":59,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":3425,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Developmental exposure to diethylstilbestrol (DES) causes reproductive tract malformations, affects fertility and increases the risk of clear cell carcinoma of the vagina and cervix in humans. Previous studies on a well-established mouse DES model demonstrated that it recapitulates many features of the human syndrome, yet the underlying molecular mechanism is far from clear. Using the neonatal DES mouse model, the present study uses global transcript profiling to systematically explore early gene expression changes in individual epithelial and mesenchymal compartments of the neonatal uterus. Over 900 genes show differential expression upon DES treatment in either one or both tissue layers. Interestingly, multiple components of the Peroxisome Proliferator-Activated Receptor gamma (PPAR\u03b3)-mediated adipogenic\/lipid metabolic pathway, including PPAR\u03b3 itself, are targets of DES in the neonatal uterus. TEM and Oil Red O staining further demonstrate a dramatic increase in lipid deposition in the uterine epithelial cells upon DES exposure. Neonatal DES exposure also perturbs glucose homeostasis in the uterine epithelium. Some of these neonatal DES-induced metabolic changes appear to last into adulthood, suggesting a permanent effect of DES on energy metabolism in uterine epithelial cells. This study extends the list of biological processes that can be regulated by estrogen or DES, and provides a novel perspective for endocrine disruptor induced reproductive abnormalities.<\/jats:p>","DOI":"10.1242\/dmm.009076","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T03:36:29Z","timestamp":1338521789000},"source":"Crossref","is-referenced-by-count":7,"title":["Neonatal diethylstilbestrol exposure alters the metabolic profile of uterine epithelial cells"],"prefix":"10.1242","author":[{"given":"Yan","family":"Yin","sequence":"first","affiliation":[{"name":"Washington University, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congxing","family":"Lin","sequence":"additional","affiliation":[{"name":"Washington University, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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Metab."},{"key":"2021042501050997200_b36-0050870","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/dbio.1998.8907","article-title":"Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES)","volume":"197","author":"Ma","year":"1998","journal-title":"Dev. Biol."},{"key":"2021042501050997200_b37-0050870","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1006\/bbrc.1996.0832","article-title":"Expression of the peroxisome proliferator-activated receptor (PPAR) in the mouse colonic mucosa","volume":"222","author":"Mansen","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042501050997200_b38-0050870","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/15287397709529453","article-title":"Prenatal exposure to diethylstilbestrol in mice: toxicological studies","volume":"2","author":"McLachlan","year":"1977","journal-title":"J. Toxicol. Environ. Health"},{"key":"2021042501050997200_b39-0050870","first-page":"3988","article-title":"Long-term effects on the female mouse genital tract associated with prenatal exposure to diethylstilbestrol","volume":"40","author":"McLachlan","year":"1980","journal-title":"Cancer Res."},{"key":"2021042501050997200_b40-0050870","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0015-0282(16)46520-9","article-title":"Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES)","volume":"38","author":"McLachlan","year":"1982","journal-title":"Fertil. Steril."},{"key":"2021042501050997200_b41-0050870","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/3027","article-title":"Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis","volume":"20","author":"Miller","year":"1998","journal-title":"Nat. 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Toxicol."},{"key":"2021042501050997200_b45-0050870","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.reprotox.2006.12.010","article-title":"Developmental exposure to endocrine disruptors and the obesity epidemic","volume":"23","author":"Newbold","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"2021042501050997200_b46-0050870","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1152\/ajpendo.00270.2004","article-title":"Depot differences in steroid receptor expression in adipose tissue: possible role of the local steroid milieu","volume":"288","author":"Rodriguez-Cuenca","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021042501050997200_b47-0050870","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1651-2227.2008.00937.x","article-title":"Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years","volume":"97","author":"Smink","year":"2008","journal-title":"Acta Paediatr."},{"key":"2021042501050997200_b48-0050870","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0020-711X(91)90121-3","article-title":"Effects of female sex hormones on lipid metabolism in the uterine epithelium of the mouse","volume":"23","author":"Stacey","year":"1991","journal-title":"Int. J. Biochem."},{"key":"2021042501050997200_b49-0050870","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/0092-8674(94)90006-X","article-title":"Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor","volume":"79","author":"Tontonoz","year":"1994","journal-title":"Cell"},{"key":"2021042501050997200_b50-0050870","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1101\/gad.873401","article-title":"Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta","volume":"15","author":"Tremblay","year":"2001","journal-title":"Genes Dev."},{"key":"2021042501050997200_b51-0050870","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/01.ede.0000220553.84350.c5","article-title":"Polybrominated biphenyls, polychlorinated biphenyls, body weight, and incidence of adult-onset diabetes mellitus","volume":"17","author":"Vasiliu","year":"2006","journal-title":"Epidemiology"},{"key":"2021042501050997200_b52-0050870","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1210\/endo.140.8.6923","article-title":"Regulation of glucose transporters by estradiol in the immature rat uterus","volume":"140","author":"Welch","year":"1999","journal-title":"Endocrinology"},{"key":"2021042501050997200_b53-0050870","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","article-title":"ATP-citrate lyase links cellular metabolism to histone acetylation","volume":"324","author":"Wellen","year":"2009","journal-title":"Science"},{"key":"2021042501050997200_b54-0050870","doi-asserted-by":"crossref","first-page":"19272","DOI":"10.1073\/pnas.1013226107","article-title":"Uterine epithelial estrogen receptor alpha is dispensable for proliferation but essential for complete biological and biochemical responses","volume":"107","author":"Winuthayanon","year":"2010","journal-title":"Proc. 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