{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:04:33Z","timestamp":1791227073608,"version":"4.1.0"},"reference-count":42,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":3425,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Recent studies indicated sortilin-related receptor 1 (SORL1) to be a risk-gene for late-onset Alzheimer's Disease (AD), although its role in the aetiology and\/or progression of this disorder is not fully understood. Here, we report the finding of a novel non-coding (nc) RNA (hereafter referred to as 51A) that maps in antisense (AS) configuration in intron 1 of SORL1 gene. 51A expression drives a splicing shift of SORL1 from the synthesis of the canonical long protein variant 1 to an alternatively spliced protein form. This process, resulting in a decreased synthesis of SORL1 variant 1, is associated with an impaired processing of APP, leading to increase of A\u03b2 formation. Interestingly, we found that 51A is expressed in human brains, being frequently up-regulated in cerebral cortices from Alzheimer's disease patients. Altogether these findings document a novel ncRNA-dependent regulatory pathway that might have relevant implications in neurodegeneration.<\/jats:p>","DOI":"10.1242\/dmm.009761","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T04:44:53Z","timestamp":1348202693000},"source":"Crossref","is-referenced-by-count":92,"title":["An intronic ncRNA-dependent regulation of SORL1 expression affecting A\u03b2 formation is upregulated in <i>post-mortem<\/i> Alzheimer's disease brain samples"],"prefix":"10.1242","author":[{"given":"Eleonora","family":"Ciarlo","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Massone","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Nizzari","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Dept of Internal Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Gigoni","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Dieci","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Molise, Campobasso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Florio","sequence":"additional","affiliation":[{"name":"Section of Pharmacology, Dept of Internal Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranieri","family":"Cancedda","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Pagano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genoa, Genoa, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2021042513082702000_b1-0060424","doi-asserted-by":"crossref","first-page":"e25097","DOI":"10.1371\/journal.pone.0025097","article-title":"Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival","volume":"6","author":"Akil","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042513082702000_b2-0060424","doi-asserted-by":"crossref","first-page":"13461","DOI":"10.1073\/pnas.0503689102","article-title":"Neuronal sorting protein-related receptor sorLA\/LR11 regulates processing of the amyloid precursor protein","volume":"102","author":"Andersen","year":"2005","journal-title":"Proc. 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