{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:12Z","timestamp":1791234732355,"version":"4.1.0"},"reference-count":73,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":3425,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk. Dietary restriction of galactose prevents or resolves the acute sequelae; however, many patients experience profound long-term complications. Despite decades of research, the mechanisms that underlie pathophysiology in classic galactosemia remain unclear. Recently, we developed a Drosophila melanogaster model of classic galactosemia and demonstrated that, like patients, GALT-null Drosophila succumb in development if exposed to galactose but live if maintained on a galactose-restricted diet. Prior models of experimental galactosemia have implicated a possible association between galactose exposure and oxidative stress. Here we describe application of our fly genetic model of galactosemia to the question of whether oxidative stress contributes to the acute galactose sensitivity of GALT-null animals. Our first approach tested the impact of pro- and antioxidant food supplements on the survival of GALT-null and control larvae. We observed a clear pattern: the oxidants paraquat and DMSO each had a negative impact on the survival of mutant but not control animals exposed to galactose, and the antioxidants vitamin C and \u03b1-mangostin each had the opposite effect. Biochemical markers also confirmed that galactose and paraquat synergistically increased oxidative stress on all cohorts tested but, interestingly, the mutant animals showed a decreased response relative to controls. Finally, we tested the expression levels of two transcripts responsive to oxidative stress, GSTD6 and GSTE7, in mutant and control larvae exposed to galactose and found that both genes were induced, one by more than 40-fold. Combined, these results implicate oxidative stress and response as contributing factors in the acute galactose sensitivity of GALT-null Drosophila and, by extension, suggest that reactive oxygen species might also contribute to the acute pathophysiology in classic galactosemia.<\/jats:p>","DOI":"10.1242\/dmm.010207","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T06:31:15Z","timestamp":1341556275000},"source":"Crossref","is-referenced-by-count":41,"title":["Oxidative stress contributes to outcome severity in a <i>Drosophila melanogaster<\/i> model of classic galactosemia"],"prefix":"10.1242","author":[{"given":"Patricia P.","family":"Jumbo-Lucioni","sequence":"first","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marquise L.","family":"Hopson","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darwin","family":"Hang","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Liang","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L.","family":"Fridovich-Keil","sequence":"additional","affiliation":[{"name":"Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2012,1,1]]},"reference":[{"key":"2021042423045248100_b1-0060084","doi-asserted-by":"crossref","first-page":"e28536","DOI":"10.1371\/journal.pone.0028536","article-title":"Galactose enhances oxidative metabolism and reveals mitochondrial dysfunction in human primary muscle cells","volume":"6","author":"Aguer","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042423045248100_b2-0060084","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1002\/pmic.200700070","article-title":"Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge","volume":"7","author":"Alias","year":"2007","journal-title":"Proteomics"},{"key":"2021042423045248100_b3-0060084","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/gerona\/63.1.35","article-title":"The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress","volume":"63","author":"Bahadorani","year":"2008","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"2021042423045248100_b4-0060084","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1373\/clinchem.2010.145359","article-title":"Galactosemia diagnosis gets an upgrade","volume":"56","author":"Bennett","year":"2010","journal-title":"Clin. Chem."},{"key":"2021042423045248100_b5-0060084","volume-title":"Biochemistry","author":"Berg","year":"2002"},{"key":"2021042423045248100_b6-0060084","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0140-6736(95)91745-4","article-title":"Endogenous synthesis of galactose in normal men and patients with hereditary galactosemia","volume":"346","author":"Berry","year":"1995","journal-title":"Lancet"},{"key":"2021042423045248100_b7-0060084","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0306-9877(02)00347-X","article-title":"Galactose-1-phosphate is a regulator of inositol monophosphatase: a fact or a fiction?","volume":"60","author":"Bhat","year":"2003","journal-title":"Med. Hypotheses"},{"key":"2021042423045248100_b8-0060084","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s11064-006-9194-8","article-title":"Paraquat-induced oxidative stress in Drosophila melanogaster: effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid","volume":"31","author":"Bonilla","year":"2006","journal-title":"Neurochem. Res."},{"key":"2021042423045248100_b9-0060084","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s10545-006-0382-0","article-title":"Classical galactosaemia revisited","volume":"29","author":"Bosch","year":"2006","journal-title":"J. Inherit. Metab. Dis."},{"key":"2021042423045248100_b10-0060084","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10545-010-9157-8","article-title":"Classic galactosemia: dietary dilemmas","volume":"34","author":"Bosch","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"2021042423045248100_b11-0060084","article-title":"Toward improved therapy for classic galactosemia","volume-title":"Probe Reports from the NIH Molecular Libraries Program [Internet]","author":"Boxer","year":"2010"},{"key":"2021042423045248100_b12-0060084","doi-asserted-by":"crossref","first-page":"842","DOI":"10.3945\/jn.109.120022","article-title":"Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media","volume":"140","author":"Bumrungpert","year":"2010","journal-title":"J. Nutr."},{"key":"2021042423045248100_b13-0060084","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10522-004-2570-3","article-title":"D-Galactose-caused life shortening in Drosophila melanogaster and Musca domestica is associated with oxidative stress","volume":"5","author":"Cui","year":"2004","journal-title":"Biogerontology"},{"key":"2021042423045248100_b14-0060084","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20899","article-title":"Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid","volume":"84","author":"Cui","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"2021042423045248100_b15-0060084","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1099\/00221287-44-2-149","article-title":"The Crabtree effect: a regulatory system in yeast","volume":"44","author":"De Deken","year":"1966","journal-title":"J. Gen. Microbiol."},{"key":"2021042423045248100_b16-0060084","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/genetics\/49.5.837","article-title":"Enzymatic expression and genetic linkage of genes controlling galactose utilization in Saccharomyces","volume":"49","author":"Douglas","year":"1964","journal-title":"Genetics"},{"key":"2021042423045248100_b17-0060084","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/10715760500104025","article-title":"Review part of the series: From dietary antioxidants to regulators in cellular signalling and gene expression review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C","volume":"39","author":"Duarte","year":"2005","journal-title":"Free Radic. Res."},{"key":"2021042423045248100_b18-0060084","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2337\/diab.33.1.97","article-title":"Experimental galactosemia produces diabetic-like retinopathy","volume":"33","author":"Engerman","year":"1984","journal-title":"Diabetes"},{"key":"2021042423045248100_b19-0060084","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1096\/fasebj.10.4.8647345","article-title":"The Leloir pathway: a mechanistic imperative for three enzymes to change the sterochemical configuration of a single carbon in galactose","volume":"10","author":"Frey","year":"1996","journal-title":"FASEB J."},{"key":"2021042423045248100_b20-0060084","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jcp.20820","article-title":"Galactosemia: the good, the bad, and the unknown","volume":"209","author":"Fridovich-Keil","year":"2006","journal-title":"J. Cell Physiol."},{"key":"2021042423045248100_b21-0060084","unstructured":"Fridovich-Keil\u2008J. L., Walter\u2008J. H. (2008). Galactosemia. In The Online Metabolic & Molecular Bases of Inherited Disease, Part 7, Chapter 72 (eds Valle\u2008D., Beaudet\u2008A., Vogelstein\u2008B., Kinzler\u2008K., Antonarakis\u2008S., Ballabio\u2008A.). New York: McGraw Hill. http:\/\/www.ommbid.com\/OMMBID\/a\/c.html\/carbohydrates\/galactosemia."},{"issue":"Suppl. 2","key":"2021042423045248100_b22-0060084","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1007\/BF02143803","article-title":"Galactose-1-phosphate in the pathophysiology of galactosemia","volume":"154","author":"Gitzelmann","year":"1995","journal-title":"Eur. J. Pediatrics"},{"key":"2021042423045248100_b23-0060084","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000469448","article-title":"Galactosemia: how does long-term treatment change the outcome?","volume":"32","author":"Gitzelmann","year":"1984","journal-title":"Enzyme"},{"key":"2021042423045248100_b24-0060084","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2164-11-47","article-title":"Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth","volume":"11","author":"Guenin","year":"2010","journal-title":"BMC Genomics"},{"key":"2021042423045248100_b25-0060084","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1023\/A:1022417102206","article-title":"Establishment of the mimetic aging effect in mice caused by D-galactose","volume":"4","author":"Ho","year":"2003","journal-title":"Biogerontology"},{"key":"2021042423045248100_b26-0060084","doi-asserted-by":"crossref","first-page":"43885","DOI":"10.1074\/jbc.R300025200","article-title":"Structure and function of enzymes of the Leloir pathway for galactose metabolism","volume":"278","author":"Holden","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021042423045248100_b27-0060084","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jpeds.2008.11.052","article-title":"Outcomes of siblings with classical galactosemia","volume":"154","author":"Hughes","year":"2009","journal-title":"J. Pediatr."},{"key":"2021042423045248100_b28-0060084","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0006-291X(81)91552-7","article-title":"The formation of superoxide radical anions by a reaction between O2, OH\u2212 and dimethyl sulfoxide","volume":"102","author":"Hyland","year":"1981","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042423045248100_b29-0060084","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0009-8981(98)00089-8","article-title":"Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC","volume":"275","author":"Jones","year":"1998","journal-title":"Clin. 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Dis."},{"key":"2021042423045248100_b33-0060084","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1021\/jf052649z","article-title":"Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)","volume":"54","author":"Jung","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"2021042423045248100_b34-0060084","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/PL00008654","article-title":"Multiple copies of MRG19 suppress transcription of the GAL1 promoter in a GAL80-dependent manner in Saccharomyces cerevisiae","volume":"262","author":"Kabir","year":"2000","journal-title":"Mol. Gen. Genet."},{"key":"2021042423045248100_b35-0060084","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S0891-5849(99)00145-8","article-title":"Glutathione redox potential in response to differentiation and enzyme inducers","volume":"27","author":"Kirlin","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"2021042423045248100_b36-0060084","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0891-5849(96)00347-4","article-title":"Abnormalities of retinal metabolism in diabetes or experimental galactosemia. IV. Antioxidant defense system","volume":"22","author":"Kowluru","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"2021042423045248100_b37-0060084","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1242\/dmm.005041","article-title":"A Drosophila melanogaster model of classic galactosemia","volume":"3","author":"Kushner","year":"2010","journal-title":"Dis. Model. Mech."},{"key":"2021042423045248100_b38-0060084","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1006\/bbrc.2000.2629","article-title":"Overexpression of human UDP-glucose pyrophosphorylase rescues galactose-1-phosphate uridyltransferase-deficient yeast","volume":"271","author":"Lai","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021042423045248100_b39-0060084","first-page":"249","article-title":"The biological activity of alpha-mangostin, a larvicidal botanic mosquito sterol carrier protein-2 inhibitor","volume":"47","author":"Larson","year":"2010","journal-title":"J. Med. Entomol."},{"key":"2021042423045248100_b40-0060084","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.mehy.2005.06.025","article-title":"The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia","volume":"65","author":"Lebea","year":"2005","journal-title":"Med. Hypotheses"},{"key":"2021042423045248100_b41-0060084","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev.nutr.23.011702.073135","article-title":"Insights into the pathogenesis of galactosemia","volume":"23","author":"Leslie","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"2021042423045248100_b42-0060084","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2583.2008.00808.x","article-title":"Transcriptomic profiles of Drosophila melanogaster third instar larval midgut and responses to oxidative stress","volume":"17","author":"Li","year":"2008","journal-title":"Insect Mol. Biol."},{"key":"2021042423045248100_b43-0060084","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10522-007-9081-y","article-title":"D-Galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid","volume":"8","author":"Long","year":"2007","journal-title":"Biogerontology"},{"key":"2021042423045248100_b44-0060084","doi-asserted-by":"crossref","first-page":"12591","DOI":"10.1021\/jp205496u","article-title":"Free radical scavenger properties of alpha-mangostin: thermodynamics and kinetics of HAT and RAF mechanisms","volume":"115","author":"Martinez","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"2021042423045248100_b45-0060084","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0304-4165(73)90184-0","article-title":"The metabolism of galactose by galactosemia fibroblasts","volume":"313","author":"Mayes","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042423045248100_b46-0060084","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0925-4439(99)00037-X","article-title":"Expression of human inositol monophosphatase suppresses galactose toxicity in Saccharomyces cerevisiae: possible implications for galactosemia","volume":"1454","author":"Mehta","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"2021042423045248100_b47-0060084","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/jn\/132.8.2303","article-title":"Oxidation of the glutathione\/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells","volume":"132","author":"Miller","year":"2002","journal-title":"J. Nutr."},{"key":"2021042423045248100_b48-0060084","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1475-2891-2-7","article-title":"Vitamin C in human health and disease is still a mystery? An overview","volume":"2","author":"Naidu","year":"2003","journal-title":"Nutr. J."},{"key":"2021042423045248100_b49-0060084","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1076\/ceyr.16.1.34.5113","article-title":"Glycolytic pathway, redox state of NAD(P)-couples and energy metabolism in lens in galactose-fed rats: effect of an aldose reductase inhibitor","volume":"16","author":"Obrosova","year":"1997","journal-title":"Curr. Eye Res."},{"key":"2021042423045248100_b50-0060084","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1086\/498985","article-title":"Epimerase-deficiency galactosemia is not a binary condition","volume":"78","author":"Openo","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"2021042423045248100_b51-0060084","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0006-8993(97)01042-1","article-title":"Brain inositol monophosphatase identified as a galactose-1-phosphatase","volume":"778","author":"Parthasarathy","year":"1997","journal-title":"Brain Res."},{"key":"2021042423045248100_b52-0060084","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.etp.2008.11.002","article-title":"ROS scavenging capacity and neuroprotective effect of alpha-mangostin against 3-nitropropionic acid in cerebellar granule neurons","volume":"61","author":"Pedraza-Chaverri","year":"2009","journal-title":"Exp. Toxicol. Pathol."},{"key":"2021042423045248100_b53-0060084","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/clinchem\/28.2.301","article-title":"Clinical significance of plasma galactose and erythrocyte galactose-1-phosphate measurements in transferase-deficient galactosemia and in individuals with below-normal transferase activity","volume":"28","author":"Pesce","year":"1982","journal-title":"Clin. Chem."},{"key":"2021042423045248100_b54-0060084","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1096\/fasebj.7.12.8375611","article-title":"Biology of free radical scavengers: an evaluation of ascorbate","volume":"7","author":"Rose","year":"1993","journal-title":"FASEB J."},{"key":"2021042423045248100_b55-0060084","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ymgme.2004.07.005","article-title":"Differential roles of the Leloir pathway enzymes and metabolites in defining galactose sensitivity in yeast","volume":"83","author":"Ross","year":"2004","journal-title":"Mol. Gen. Metab."},{"key":"2021042423045248100_b56-0060084","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ab.2011.08.023","article-title":"Paraquat administration in Drosophila for use in metabolic studies of oxidative stress","volume":"419","author":"Rzezniczak","year":"2011","journal-title":"Anal. Biochem."},{"key":"2021042423045248100_b57-0060084","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.clnu.2004.09.001","article-title":"The effect of diet on total antioxidant status, erythrocyte membrane Na+,K+-ATPase and Mg2+-ATPase activities in patients with classical galactosaemia","volume":"24","author":"Schulpis","year":"2005","journal-title":"Clinical Nutr."},{"key":"2021042423045248100_b58-0060084","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1080\/08035250500297810","article-title":"8-Hydroxy-2-desoxyguanosine serum concentrations as a marker of DNA damage in patients with classical galactosaemia","volume":"95","author":"Schulpis","year":"2006","journal-title":"Acta Paediatr."},{"key":"2021042423045248100_b59-0060084","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1007\/s00431-003-1352-2","article-title":"Early diagnosis of inherited metabolic disorders towards improving outcome: the controversial issue of galactosaemia","volume":"162","author":"Schweitzer-Krantz","year":"2003","journal-title":"Eur. 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Brain Dis."},{"key":"2021042423045248100_b66-0060084","article-title":"Galactosemia","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Tyfield","year":"2002"},{"key":"2021042423045248100_b67-0060084","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1475-2891-8-48","article-title":"Evaluation of mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study","volume":"8","author":"Udani","year":"2009","journal-title":"Nutr. J."},{"key":"2021042423045248100_b68-0060084","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF01800204","article-title":"Long-term prognosis in galactosaemia: results of a survey of 350 cases","volume":"13","author":"Waggoner","year":"1990","journal-title":"J. Inherit. Metab. 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