{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:27:28Z","timestamp":1787585248088,"version":"build-2736575974"},"reference-count":42,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":3059,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The regenerative response to drug- and toxin-induced liver injury induces changes to the hepatic stroma, including the extracellular matrix. Although the extracellular matrix is known to undergo significant changes during the injury response, its impact on maintaining hepatocyte function and viability in this process remains largely unknown. We demonstrate that recovery from toxin-mediated injury is impaired in mice deficient in a key liver extracellular matrix molecule, type XVIII collagen, and results in rapid death. The type-XVIII-collagen-dependent response to liver injury is mediated by survival signals induced by \u03b11\u03b21 integrin, integrin linked kinase and the Akt pathway, and mice deficient in either \u03b11\u03b21 integrin or hepatocyte integrin linked kinase also succumb to toxic liver injury. These findings demonstrate that type XVIII collagen is an important functional component of the liver matrix microenvironment and is crucial for hepatocyte survival during injury and stress.<\/jats:p>","DOI":"10.1242\/dmm.011577","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:18:19Z","timestamp":1365121099000},"source":"Crossref","is-referenced-by-count":20,"title":["Type XVIII collagen is essential for survival during acute liver injury in mice"],"prefix":"10.1242","author":[{"given":"Michael B.","family":"Duncan","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Yang","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishna","family":"Tanjore","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doruk","family":"Keskin","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zeisberg","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn R.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042501084951200_b1-0060942","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/hep.23059","article-title":"Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase","volume":"50","author":"Apte","year":"2009","journal-title":"Hepatology"},{"key":"2021042501084951200_b2-0060942","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1096\/fasebj.10.13.8940293","article-title":"Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration","volume":"10","author":"Berthiaume","year":"1996","journal-title":"FASEB J."},{"key":"2021042501084951200_b3-0060942","doi-asserted-by":"crossref","first-page":"15143","DOI":"10.1073\/pnas.96.26.15143","article-title":"Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver","volume":"96","author":"Bezerra","year":"1999","journal-title":"Proc. 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