{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:03Z","timestamp":1787021403106,"version":"build-2736575974"},"reference-count":64,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":3059,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>We assessed feeding-related developmental anomalies in the LgDel mouse model of Chromosome 22q11 Deletion Syndrome (22q11DS), a common developmental disorder that frequently includes perinatal dysphagia - debilitating feeding, swallowing and nutrition difficulties from birth onward - within its phenotypic spectrum. LgDel pups gain significantly less weight during the first postnatal weeks, and have several signs of respiratory infections due to food aspiration. Most 22q11 genes are expressed in anlagen of craniofacial and brainstem regions critical for feeding and swallowing, and diminished expression in LgDel embryos apparently compromises development of these regions. Palate and jaw anomalies indicate divergent oro-facial morphogenesis. Altered expression and patterning of hindbrain transcriptional regulators, especially those related to retinoic acid (RA) signaling prefigures these disruptions. Subsequently, gene expression, axon growth and sensory ganglion formation in the trigeminal (V), glossopharyngeal (IX), or vagus (X) cranial nerves (CN) that innervate targets essential for feeding, swallowing and digestion are disrupted. Posterior CN IX and X ganglia anomalies primarily reflect diminished dosage of the 22q11DS candidate gene Tbx1. Genetic modification of RA signaling in LgDel embryos rescues the anterior CN V phenotype and returns expression levels or pattern of RA-sensitive genes to that in wild type embryos. Thus, diminished 22q11 gene dosage, including but not limited to Tbx1, disrupts oro-facial and cranial nerve development by modifying RA-modulated anterior-posterior hindbrain differentiation. These disruptions likely contribute to dysphagia in infants and young children with 22q11DS.<\/jats:p>","DOI":"10.1242\/dmm.012484","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:10:08Z","timestamp":1387498208000},"source":"Crossref","is-referenced-by-count":42,"title":["Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge\/22q11 Deletion Syndrome"],"prefix":"10.1242","author":[{"given":"Beverly A.","family":"Karpinski","sequence":"first","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Maynard","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Fralish","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Nuwayhid","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Zohn","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Moody","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony-S.","family":"LaMantia","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2021042501345323300_b1-0070245","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1074\/jbc.273.4.2409","article-title":"Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha","volume":"273","author":"Abu-Abed","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021042501345323300_b2-0070245","first-page":"H1552","article-title":"Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats","volume":"276","author":"Ang","year":"1999","journal-title":"Am. J. Physiol."},{"key":"2021042501345323300_b3-0070245","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1242\/dev.02264","article-title":"Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations","volume":"133","author":"Arnold","year":"2006","journal-title":"Development"},{"key":"2021042501345323300_b4-0070245","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/pgmj.75.884.373","article-title":"Dysphagia and hypercalcaemia","volume":"75","author":"Balcombe","year":"1999","journal-title":"Postgrad. Med. J."},{"key":"2021042501345323300_b5-0070245","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/dev.127.5.933","article-title":"Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse","volume":"127","author":"Barrow","year":"2000","journal-title":"Development"},{"key":"2021042501345323300_b6-0070245","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.biopsych.2007.04.019","article-title":"Olfaction and taste processing in autism","volume":"62","author":"Bennetto","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"2021042501345323300_b7-0070245","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-213X-9-31","article-title":"Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis","volume":"9","author":"Braunstein","year":"2009","journal-title":"BMC Dev. Biol."},{"key":"2021042501345323300_b8-0070245","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1242\/dev.028902","article-title":"Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm","volume":"136","author":"Calmont","year":"2009","journal-title":"Development"},{"key":"2021042501345323300_b9-0070245","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00129492-200305000-00003","article-title":"Eustachian tube goblet cell density during and after acute otitis media caused by Streptococcus pneumoniae: a morphometric analysis","volume":"24","author":"Cay\u00e9-Thomasen","year":"2003","journal-title":"Otol. Neurotol."},{"key":"2021042501345323300_b10-0070245","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF02407131","article-title":"Developmental approach to pediatric neurogenic dysphagia","volume":"3","author":"Christensen","year":"1989","journal-title":"Dysphagia"},{"key":"2021042501345323300_b11-0070245","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/35090039","article-title":"Molecular genetics of cranial nerve development in mouse","volume":"2","author":"Cordes","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042501345323300_b12-0070245","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1067\/mpd.2000.105356","article-title":"Dysphagia in children with a 22q11.2 deletion: unusual pattern found on modified barium swallow","volume":"137","author":"Eicher","year":"2000","journal-title":"J. Pediatr."},{"key":"2021042501345323300_b13-0070245","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0065-3101(23)00073-7","article-title":"The 22q11.2 deletion syndrome","volume":"48","author":"Emanuel","year":"2001","journal-title":"Adv. Pediatr."},{"key":"2021042501345323300_b14-0070245","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ijporl.2011.06.013","article-title":"Cleft palate, retrognathia and congenital heart disease in velo-cardio-facial syndrome: a phenotype correlation study","volume":"75","author":"Friedman","year":"2011","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"2021042501345323300_b15-0070245","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1067\/moe.2000.103884","article-title":"Oral findings in DiGeorge syndrome: clinical features and histologic study of primary teeth","volume":"89","author":"Fukui","year":"2000","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 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Otolaryngol."},{"key":"2021042501345323300_b22-0070245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/jp.2008.136","article-title":"Feeding abilities in neonates with congenital heart disease: a retrospective study","volume":"29","author":"Jadcherla","year":"2009","journal-title":"J. Perinatol."},{"key":"2021042501345323300_b23-0070245","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1067\/mpd.2001.118534","article-title":"Immunologic features of chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome)","volume":"139","author":"Jawad","year":"2001","journal-title":"J. Pediatr."},{"key":"2021042501345323300_b24-0070245","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/85845","article-title":"DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1","volume":"27","author":"Jerome","year":"2001","journal-title":"Nat. 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USA"},{"key":"2021042501345323300_b36-0070245","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/hmg\/dds429","article-title":"22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development","volume":"22","author":"Maynard","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"2021042501345323300_b37-0070245","doi-asserted-by":"crossref","first-page":"16434","DOI":"10.1073\/pnas.0905696106","article-title":"Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion\/DiGeorge syndrome","volume":"106","author":"Meechan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. 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Dyn."},{"key":"2021042501345323300_b41-0070245","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1002\/dvdy.21715","article-title":"Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice","volume":"237","author":"Okano","year":"2008","journal-title":"Dev. Dyn."},{"key":"2021042501345323300_b42-0070245","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/dvdy.23862","article-title":"The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves","volume":"241","author":"Okano","year":"2012","journal-title":"Dev. Dyn."},{"key":"2021042501345323300_b43-0070245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11920-007-0085-8","article-title":"A review of neurocognitive and behavioral profiles associated with 22q11 deletion syndrome: implications for clinical evaluation and treatment","volume":"9","author":"Ousley","year":"2007","journal-title":"Curr. Psychiatry Rep."},{"key":"2021042501345323300_b44-0070245","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1017\/S0022215111001605","article-title":"Vascular rings and slings: interesting vascular anomalies","volume":"125","author":"Phelan","year":"2011","journal-title":"J. Laryngol. Otol."},{"issue":"Suppl. 1","key":"2021042501345323300_b45-0070245","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1093\/jhered\/esr053","article-title":"A rare form of persistent right aorta arch in linkage disequilibrium with the DiGeorge critical region on CFA26 in German Pinschers","volume":"102","author":"Philipp","year":"2011","journal-title":"J. Hered."},{"key":"2021042501345323300_b46-0070245","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/dev.01067","article-title":"Suppression of neural fate and control of inner ear morphogenesis by Tbx1","volume":"131","author":"Raft","year":"2004","journal-title":"Development"},{"key":"2021042501345323300_b47-0070245","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1567-133X(03)00112-1","article-title":"Expression of the retinoic acid catabolising enzyme CYP26B1 in the chick embryo and its regulation by retinoic acid","volume":"3","author":"Reijntjes","year":"2003","journal-title":"Gene Expr. 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A."},{"key":"2021042501345323300_b60-0070245","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s10803-011-1377-8","article-title":"Taste identification in adults with autism spectrum conditions","volume":"42","author":"Tavassoli","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"2021042501345323300_b61-0070245","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35039056","article-title":"Patterning the cranial neural crest: hindbrain segmentation and Hox gene plasticity","volume":"1","author":"Trainor","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"2021042501345323300_b62-0070245","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpedsurg.2011.11.019","article-title":"Reflux aspiration in children with neurodisability \u2013 a significant problem, but can we measure it?","volume":"47","author":"Trinick","year":"2012","journal-title":"J. Pediatr. 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