{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:01:44Z","timestamp":1753884104059,"version":"3.41.2"},"reference-count":68,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":2694,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Focal and segmental glomerulosclerosis (FSGS) is one of the most important renal diseases related to end stage renal failure. Bradykinin has been implicated in the pathogenesis of renal inflammation whereas the role of its receptor 2 (B2RBK) in FSGS has not been studied. FSGS was induced in wild type and B2RBK KO mice by a single intravenous injection of Adriamycin (ADM). In order to further modulate the kinin receptors, animals were also treated with B2RBK antagonist HOE-140, and DALBK, B1RBK antagonist. Here, we show that the blockage of B2RBK with HOE-140 protects mice from FSGS development, including podocyte foot process effacement and reestablishment of slit diaphragm-related proteins. However, B2RBK KO mice were not protected from FSGS. These opposite results were due to B1RBK expression. B1RBK was up regulated after ADM injection and it was exacerbated in B2RBK KO animals. Further, HOE-140 treatment down regulated B1RBK receptor. The blockade of B1RBK in B2RBK KO animals promoted FSGS regression, with a less inflammatory phenotype. These results indicate a deleterious role of both kinin receptors in FSGS model and suggest a possible crosstalk of them in disease progression.<\/jats:p>","DOI":"10.1242\/dmm.014548","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T06:04:10Z","timestamp":1397801050000},"source":"Crossref","is-referenced-by-count":8,"title":["The balance of kinin receptors in the progression of experimental focal and segmental glomerulosclerosis"],"prefix":"10.1242","author":[{"given":"Rafael Luiz","family":"Pereira","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Jos\u00e9 Ferreira","family":"Felizardo","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Ant\u00f4nio","family":"Cenedeze","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meire Ioshie","family":"Hiyane","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00canio Jos\u00e9","family":"Bassi","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariane Tami","family":"Amano","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice Sylvia Taemi","family":"Origassa","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinaldo Correia","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristhiane F\u00e1vero","family":"Aguiar","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia Mendes","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Instituto Butantan, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Bosco","family":"Pesquero","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronaldo Carvalho","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre de Castro","family":"Keller","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Cruz","family":"Moura","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Pacheco-Silva","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Olsen Saraiva","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042501154684500_b1-0070701","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/35024095","article-title":"AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration","volume":"407","author":"AbdAlla","year":"2000","journal-title":"Nature"},{"key":"2021042501154684500_b2-0070701","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nm0901-1003","article-title":"Increased AT (1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness","volume":"7","author":"AbdAlla","year":"2001","journal-title":"Nat. Med."},{"key":"2021042501154684500_b3-0070701","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/ajrccm\/143.4_Pt_1.787","article-title":"A bradykinin antagonist modifies allergen-induced mediator release and late bronchial responses in sheep","volume":"143","author":"Abraham","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021042501154684500_b4-0070701","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4049\/jimmunol.156.1.269","article-title":"Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse","volume":"156","author":"Ahluwalia","year":"1996","journal-title":"J. Immunol."},{"key":"2021042501154684500_b5-0070701","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1681\/ASN.V94598","article-title":"Characterization of two polymorphic sites in the human kinin B1 receptor gene: altered frequency of an allele in patients with a history of end-stage renal failure","volume":"9","author":"Bachvarov","year":"1998","journal-title":"J. Am. Soc. Nephrol."},{"key":"2021042501154684500_b6-0070701","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0702536","article-title":"Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats","volume":"127","author":"Bandeira-Melo","year":"1999","journal-title":"Br. J. 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Rev."},{"key":"2021042501154684500_b9-0070701","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1046\/j.1523-1755.2002.00385.x","article-title":"Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat","volume":"61","author":"Braun","year":"2002","journal-title":"Kidney Int."},{"key":"2021042501154684500_b10-0070701","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(00)00335-3","article-title":"Kinins in pain and inflammation","volume":"87","author":"Calixto","year":"2000","journal-title":"Pain"},{"key":"2021042501154684500_b11-0070701","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1046\/j.1440-1681.2001.03564.x","article-title":"The kallikrein-kinin system in humans","volume":"28","author":"Campbell","year":"2001","journal-title":"Clin. Exp. Pharmacol. 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Immunopharmacol."},{"key":"2021042501154684500_b15-0070701","first-page":"3","article-title":"Review on diagnosis and treatment of focal segmental glomerulosclerosis","volume":"66","author":"Deegens","year":"2008","journal-title":"Neth. J. Med."},{"key":"2021042501154684500_b16-0070701","first-page":"F779","article-title":"Sublethal X-irradiation during acute puromycin nephrosis prevents late renal injury: role of macrophages","volume":"260","author":"Diamond","year":"1991","journal-title":"Am. J. Physiol."},{"key":"2021042501154684500_b17-0070701","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1742-2094-5-49","article-title":"Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice","volume":"5","author":"Dos Santos","year":"2008","journal-title":"J. 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Kidney Dis."},{"key":"2021042501154684500_b27-0070701","first-page":"1131","article-title":"Paracrine role for TGF-\u03b2-induced CTGF and VEGF in mesangial matrix expansion in progressive glomerular disease","volume":"27","author":"Lee","year":"2012","journal-title":"Histol. Histopathol."},{"key":"2021042501154684500_b28-0070701","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000285844","article-title":"Effects of TGF-beta on podocyte growth and disease progression in proliferative podocytopathies","volume":"33","author":"Lee","year":"2010","journal-title":"Kidney Blood Press. Res."},{"key":"2021042501154684500_b29-0070701","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1139\/y02-036","article-title":"Bradykinin B2 receptor gene polymorphism is associated with altered urinary albumin\/creatinine values in diabetic patients","volume":"80","author":"Maltais","year":"2002","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2021042501154684500_b30-0070701","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02737658","article-title":"Kinin receptors","volume":"16","author":"Marceau","year":"1998","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"2021042501154684500_b31-0070701","first-page":"F532","article-title":"B2 kinin receptor upregulation by cAMP is associated with BK-induced PGE2 production in rat mesangial cells","volume":"274","author":"Marin Casta\u00f1o","year":"1998","journal-title":"Am. J. Physiol."},{"key":"2021042501154684500_b32-0070701","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1681\/ASN.2005030297","article-title":"IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease","volume":"16","author":"Mu","year":"2005","journal-title":"J. Am. Soc. 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Chem."},{"key":"2021042501154684500_b36-0070701","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ki.1997.346","article-title":"Podocytes are the major source of IL-1 alpha and IL-1 beta in human glomerulonephritides","volume":"52","author":"Niemir","year":"1997","journal-title":"Kidney Int."},{"key":"2021042501154684500_b37-0070701","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1053\/ajkd.2002.31391","article-title":"Significance of early phenotypic change of glomerular podocytes detected by Pax2 in primary focal segmental glomerulosclerosis","volume":"39","author":"Ohtaka","year":"2002","journal-title":"Am. J. Kidney Dis."},{"key":"2021042501154684500_b38-0070701","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/ki.2011.14","article-title":"Bradykinin receptor 1 activation exacerbates experimental focal and segmental glomerulosclerosis","volume":"79","author":"Pereira","year":"2011","journal-title":"Kidney Int."},{"key":"2021042501154684500_b39-0070701","doi-asserted-by":"crossref","first-page":"e32454","DOI":"10.1371\/journal.pone.0032454","article-title":"Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis","volume":"7","author":"Pereira","year":"2012","journal-title":"PLoS ONE"},{"key":"2021042501154684500_b40-0070701","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-3565(24)29354-X","article-title":"Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts","volume":"298","author":"Phagoo","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021042501154684500_b41-0070701","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0031-6997(25)06836-X","article-title":"Pharmacology of bradykinin and related kinins","volume":"32","author":"Regoli","year":"1980","journal-title":"Pharmacol. Rev."},{"key":"2021042501154684500_b42-0070701","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.imbio.2011.12.003","article-title":"The polysaccharide fraction of Propionibacterium acnes modulates the development of experimental focal segmental glomerulosclerosis","volume":"217","author":"Reis","year":"2012","journal-title":"Immunobiology"},{"key":"2021042501154684500_b43-0070701","doi-asserted-by":"crossref","first-page":"12475","DOI":"10.1074\/jbc.275.17.12475","article-title":"Des-Arg(10)-kallidin engagement of the B1 receptor stimulates type I collagen synthesis via stabilization of connective tissue growth factor mRNA","volume":"275","author":"Ricupero","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021042501154684500_b44-0070701","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.lfs.2010.10.011","article-title":"Investigation of the cardiomyocyte dysfunction in bradykinin type 2 receptor knockout mice","volume":"87","author":"Roman-Campos","year":"2010","journal-title":"Life Sci."},{"key":"2021042501154684500_b45-0070701","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1096\/fj.03-0835fje","article-title":"Interactions between bradykinin (BK) and cell adhesion molecule (CAM) expression in peptidoglycan-polysaccharide (PG-PS)-induced arthritis","volume":"18","author":"Sainz","year":"2004","journal-title":"FASEB J."},{"key":"2021042501154684500_b46-0070701","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)64421-5","article-title":"Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation","volume":"161","author":"Saleem","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2021042501154684500_b47-0070701","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1172\/JCI0215493","article-title":"In vivo bradykinin B2 receptor activation reduces renal fibrosis","volume":"110","author":"Schanstra","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2021042501154684500_b48-0070701","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/labinvest.2009.96","article-title":"Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells","volume":"89","author":"Schramek","year":"2009","journal-title":"Lab. Invest."},{"key":"2021042501154684500_b49-0070701","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.intimp.2007.08.008","article-title":"Hemodynamic and renal involvement of B1 and B2 kinin receptors during the acute phase of endotoxin shock in mice","volume":"8","author":"Seguin","year":"2008","journal-title":"Int. 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Am. Soc. Nephrol."},{"key":"2021042501154684500_b65-0070701","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsbmb.2011.12.008","article-title":"Attenuation of glomerular filtration barrier damage in adriamycin-induced nephropathic rats with bufalin: an antiproteinuric agent","volume":"129","author":"Zheng","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"2021042501154684500_b66-0070701","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1139\/y96-047","article-title":"Effects of B1 and B2 kinin receptor antagonists in diabetic mice","volume":"74","author":"Zuccollo","year":"1996","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2021042501154684500_b67-0070701","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1076\/apab.104.2.252.12890","article-title":"Effects of HOE 140 on some renal functions in type I diabetic mice","volume":"104","author":"Zuccollo","year":"1996","journal-title":"Arch. Physiol. 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