{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:56:37Z","timestamp":1791176197570,"version":"4.1.0"},"reference-count":41,"publisher":"The Company of Biologists","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world\u2019s most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg) cells are crucial in controlling the resulting inflammation. Insulin-like growth factor-1 (IGF-1) regulates cell proliferation and differentiation and accelerates wound healing and regeneration in several organs including the skin. Recently IGF-1 has also been implicated in protection from autoimmune inflammation by expansion of Treg cells. Here, we demonstrate that ectopic expression of IGF-1 in mouse skin suppresses ACD in a Treg cell-specific manner, increasing the number of Foxp3+ Treg cells in the affected area and stimulating lymphocyte production of the anti-inflammatory cytokine interleukin 10. Similar therapeutic effects can be achieved with systemic or topical delivery of IGF-1, implicating this growth factor as a promising new therapeutic option for the treatment of ACD.<\/jats:p>","DOI":"10.1242\/dmm.015362","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:48:33Z","timestamp":1406101713000},"page":"977-985","source":"Crossref","is-referenced-by-count":38,"title":["Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice"],"prefix":"10.1242","volume":"7","author":[{"given":"Bjarki","family":"Johannesson","sequence":"first","affiliation":[{"name":"Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Sattler","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Semenova","sequence":"additional","affiliation":[{"name":"Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saveria","family":"Pastore","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Immunology, Istituto Dermopatico Immacolata, IRCCS, Rome 00167, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa M.","family":"Kennedy-Lydon","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Sampson","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Schneider","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College, London W12 0NN, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy."},{"name":"National Heart and Lung Institute, Imperial College, London W12 0NN, UK."},{"name":"Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800 Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bilbao","sequence":"additional","affiliation":[{"name":"Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo, 00015, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042422434627700_b1-0070977","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1586\/eci.10.4","article-title":"Diagnostic approach in allergic and irritant contact dermatitis","volume":"6","author":"Ale","year":"2010","journal-title":"Expert Rev. 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