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Mutants show complete resistance to neomycin-induced hair cell death and partial resistance to cisplatin-induced hair cell death. This resistance is probably due to impaired drug uptake as a result of reduced mechanotransduction ability, suggesting that the mutants have defects in hair cell function independent of drug treatment. Through genetic mapping we found that merovingian mutants contain a mutation in the transcription factor gcm2. This gene is important for the production of ionocytes, which are cells crucial for whole body pH regulation in fish. We found that merovingian mutants showed an acidified extracellular environment in the vicinity of both inner ear and lateral line hair cells. We believe that this acidified extracellular environment is responsible for the defects seen in hair cells of merovingian mutants, and that these mutants would serve as a valuable model for further study of the role of pH in hair cell function.<\/jats:p>","DOI":"10.1242\/dmm.016576","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T09:37:47Z","timestamp":1403861867000},"page":"847-856","source":"Crossref","is-referenced-by-count":63,"title":["The zebrafish<i>merovingian<\/i>mutant reveals a role for pH regulation in hair cell toxicity and function"],"prefix":"10.1242","volume":"7","author":[{"given":"Tamara M.","family":"Stawicki","sequence":"first","affiliation":[{"name":"Department of Biological Structure, University of Washington, Seattle, WA 98195, USA."},{"name":"Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly N.","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Biological Structure, University of Washington, Seattle, WA 98195, USA."},{"name":"Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA."},{"name":"Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor","family":"Linbo","sequence":"additional","affiliation":[{"name":"Department of Biological Structure, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Reinhart","sequence":"additional","affiliation":[{"name":"Department of Biological Structure, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin W.","family":"Rubel","sequence":"additional","affiliation":[{"name":"Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA."},{"name":"Department of Otolaryngology, Head and Neck Surgery, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Raible","sequence":"additional","affiliation":[{"name":"Department of Biological Structure, University of Washington, Seattle, WA 98195, USA."},{"name":"Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, WA 98195, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","reference":[{"key":"2021042501215630100_b1-0070847","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/(SICI)1098-2264(199907)25:3<301::AID-GCC13>3.0.CO;2-1","article-title":"Universal linkage system: an improved method for labeling archival DNA for comparative genomic hybridization","volume":"25","author":"Alers","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"2021042501215630100_b2-0070847","doi-asserted-by":"crossref","first-page":"e22347","DOI":"10.1371\/journal.pone.0022347","article-title":"Functional hair cell mechanotransducer channels are required for aminoglycoside ototoxicity","volume":"6","author":"Alharazneh","year":"2011","journal-title":"PLoS ONE"},{"key":"2021042501215630100_b3-0070847","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ijc.2910540126","article-title":"Potentiation of DNA-adduct formation and cytotoxicity of platinum-containing drugs by low pH","volume":"54","author":"Atema","year":"1993","journal-title":"Int. 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