{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:55:14Z","timestamp":1780606514898,"version":"3.54.1"},"reference-count":21,"publisher":"The Company of Biologists","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"am","delay-in-days":2694,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, designated C57BL\/6-Tg (ITF-TMEM207), in which murine TMEM207 was ectopically expressed under a truncated (by ~200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene (also known as Tff3). Unexpectedly, a C57BL\/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. These tumors were found in ~14% female and 13% of male 6- to 12-month-old mice. TMEM207 immunoreactivity was found in hair follicle bulge cells in non-tumorous skin, as well as in cutaneous adnexal tumors of the transgenic mouse. The ITF-TMEM207 construct in this line appeared to be inserted to a major satellite repeat sequence at chromosome 2, in which no definite coding molecule was found. In addition, we also observed cutaneous adnexal tumors in three other C57BL\/6-Tg (ITF-TMEM207) transgenic mouse lines. We believe that the C57BL\/6-Tg (ITF-TMEM207) mouse might be a useful model to understand human cutaneous adnexal tumors.<\/jats:p>","DOI":"10.1242\/dmm.017574","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T06:08:43Z","timestamp":1413007723000},"source":"Crossref","is-referenced-by-count":5,"title":["Transgenic mouse model of cutaneous adnexal tumors"],"prefix":"10.1242","author":[{"given":"Yusuke","family":"Kito","sequence":"first","affiliation":[{"name":"Gifu University Graduate School of Medcine, Gifu, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemi","family":"Saigo","sequence":"additional","affiliation":[{"name":"Gifu University Graduate School of Medcine, Gifu, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurabayashi","family":"Atsushi","sequence":"additional","affiliation":[{"name":"Kochi Medical School, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furihata","family":"Mutsuo","sequence":"additional","affiliation":[{"name":"Kochi Medical School, Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeuchi","family":"Tamotsu","sequence":"additional","affiliation":[{"name":"Gifu University Graduate School of Medcine, Gifu, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"237","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2021042501172440500_b1-0071379","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00403-014-1442-1","article-title":"Expression of ZNF396 in basal cell carcinoma","volume":"306","author":"Bai","year":"2014","journal-title":"Arch. 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